RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
$tril #CD47 In preclinical models, liver-directed radiotherapy eliminates immunosuppressive hepatic macrophages, increases hepatic T cell survival and reduces hepatic siphoning of T cells. https://t.co/NsY0yAvwwR
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @HolabUnil: T cell graveyard! Let’s see what we can do to make it become T cell wonderland🤪
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
@ColmJJORourke
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @SaldanhaMd: Brillant paper by Yu et al. that addresses worst outcomes in pts with liver Mets treated with immunotherapy. What is the…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @hotirishmonkey: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://…
RT @HolabUnil: T cell graveyard! Let’s see what we can do to make it become T cell wonderland🤪
RT @HolabUnil: T cell graveyard! Let’s see what we can do to make it become T cell wonderland🤪 https://t.co/zFrOvcuBu1
T cell graveyard! Let’s see what we can do to make it become T cell wonderland🤪
RT @hotirishmonkey: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://…
RT @hotirishmonkey: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
Liver metastases function as a "T-cell graveyard" leading to systemic immune deserts in a variety of solid tumors including melanoma and NSCLC. https://t.co/p0RkzvoMaU @sghmd @AmitKulkarniMD
RT @hotirishmonkey: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://…
RT @hotirishmonkey: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @hotirishmonkey: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @hotirishmonkey: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://…
RT @hotirishmonkey: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://…
RT @asharmaiisc: Indeed, HCC is T cell graveyard!! https://t.co/nVujRIiASo
RT @asharmaiisc: Indeed, HCC is T cell graveyard!! https://t.co/nVujRIiASo
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
Indeed, HCC is T cell graveyard!!
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co/bw502BL2tt
The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcells & trigger their apoptosis (driven by monocyte-derived macrophages) More evidence the liver = a Tcell graveyard @NatureMed
don't forget the liver (mets) https://t.co/QsvHOuu8DK
RT @SaldanhaMd: Brillant paper by Yu et al. that addresses worst outcomes in pts with liver Mets treated with immunotherapy. What is the…
RT @SaldanhaMd: Brillant paper by Yu et al. that addresses worst outcomes in pts with liver Mets treated with immunotherapy. What is the…
RT @SaldanhaMd: Brillant paper by Yu et al. that addresses worst outcomes in pts with liver Mets treated with immunotherapy. What is the…
RT @SaldanhaMd: Brillant paper by Yu et al. that addresses worst outcomes in pts with liver Mets treated with immunotherapy. What is the…
RT @SaldanhaMd: Brillant paper by Yu et al. that addresses worst outcomes in pts with liver Mets treated with immunotherapy. What is the…
Brillant paper by Yu et al. that addresses worst outcomes in pts with liver Mets treated with immunotherapy. What is the role of liver metastasis in systemic immunity and IO efficacy? https://t.co/siXwa5K2gJ
Yet another histology showing diminished response to ICI with liver mets. A widespread finding. https://t.co/qABotafwka
Fantastic work indeed.
RT @XShirleyLiu: This is amazing work! There are some hidden novel targets in the data here. https://t.co/ZUzANUaZVv
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co/ZZfDJNODDh
This is amazing work! There are some hidden novel targets in the data here. https://t.co/ZUzANUaZVv
The role of immunotherapy in liver metastasis! https://t.co/FdypIfGERv Great work! @nature @MichiganLiver
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
Not all anatomic sites for metastases are created equal. Awesome review. Maybe we can do some cool stuff with SMART @lauren_henke
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @MetastasisRS: A new study on @NatureMedicine explains why patients with liver metastasis respond poorly to immunotherapy. By causing ap…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but therapeutic benefit can be improved by combining with liver-directed #radiotherapy #metastasis #macrophages @UMichSurgery @umichmedicine ht
Interesting! Thanks for sharing! @ErezNeta @MetastasisRS @NatureMedicine #liver #immunotherapy https://t.co/q8AHa9VK70
@Jcj84Jeremy Important info to consider for MSI CRCSM pts. Relates to recent posts @mgfakih https://t.co/7pwhm7AJqe @BReinfeld https://t.co/Wou3sDYSzN
RT @MetastasisRS: A new study on @NatureMedicine explains why patients with liver metastasis respond poorly to immunotherapy. By causing ap…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @MetastasisRS: A new study on @NatureMedicine explains why patients with liver metastasis respond poorly to immunotherapy. By causing ap…
RT @MetastasisRS: A new study on @NatureMedicine explains why patients with liver metastasis respond poorly to immunotherapy. By causing ap…
RT @MetastasisRS: A new study on @NatureMedicine explains why patients with liver metastasis respond poorly to immunotherapy. By causing ap…
#Livermetastasis restrains #immunotherapy efficacy via #macrophage-mediated #Tcell elimination https://t.co/kugk4xsSpH @NatureMedicine @UMich @UMichiganNews #Radiotherapy
RT @coughlin582: Liver - unfriendly place for IO therapy. First described by @AdilDaud3 More on mech here. https://t.co/JR4ZJTddyk https…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @MetastasisRS: A new study on @NatureMedicine explains why patients with liver metastasis respond poorly to immunotherapy. By causing ap…
RT @MetastasisRS: A new study on @NatureMedicine explains why patients with liver metastasis respond poorly to immunotherapy. By causing ap…
RT @MetastasisRS: A new study on @NatureMedicine explains why patients with liver metastasis respond poorly to immunotherapy. By causing ap…
RT @AmaiaLujambio: Check out our News & Views on this fantastic paper! Metastasis to liver inhibits immunotherapy efficacy. @KatieLindblad1…
Check out our News & Views on this fantastic paper! Metastasis to liver inhibits immunotherapy efficacy. @KatieLindblad1 @NatureMedicine @TischCancer @MountSinaiLiver @IcahnMountSinai @SinaiImmunol @GradSchoolSinai https://t.co/r6ClAIhclu
Important paper in @NatureMedicine showing that liver metastases co-opt host peripheral tolerance mechanisms to cause acquired immunotherapy resistance through CD8+ T cell deletion, which can be overcome by radiotherapy (https://t.co/z0rFDzZUPz). https://
RT @MetastasisRS: A new study on @NatureMedicine explains why patients with liver metastasis respond poorly to immunotherapy. By causing ap…
RT @MetastasisRS: A new study on @NatureMedicine explains why patients with liver metastasis respond poorly to immunotherapy. By causing ap…
A new study on @NatureMedicine explains why patients with liver metastasis respond poorly to immunotherapy. By causing apoptosis of CD8+ T cells, macrophages in the metastatic liver act as sponges of systemic anti-tumor immunity. https://t.co/eG8bgTWRw3
RT @coughlin582: Liver - unfriendly place for IO therapy. First described by @AdilDaud3 More on mech here. https://t.co/JR4ZJTddyk https…
RT @coughlin582: Liver - unfriendly place for IO therapy. First described by @AdilDaud3 More on mech here. https://t.co/JR4ZJTddyk https…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @AdilDaud3: Thanks @coughlin582 ! Adding a paper from James Lee and @kickassscience1 declining into the mechanism https://t.co/nGgNfMRb1…
Great work 👌🏻👏🏻👏🏻. Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co/YpfhcUiyK3
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatRevClinOncol: Studies in mice and patients indicate that liver metastasis restrains immunotherapy efficacy via macrophage-mediated T…
Thanks @coughlin582 ! Adding a paper from James Lee and @kickassscience1 declining into the mechanism https://t.co/nGgNfMRb1x
RT @coughlin582: Liver - unfriendly place for IO therapy. First described by @AdilDaud3 More on mech here. https://t.co/JR4ZJTddyk https…
RT @coughlin582: Liver - unfriendly place for IO therapy. First described by @AdilDaud3 More on mech here. https://t.co/JR4ZJTddyk https…
Liver - unfriendly place for IO therapy. First described by @AdilDaud3 More on mech here. https://t.co/JR4ZJTddyk https://t.co/v45ouqLyQF
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatRevClinOncol: Studies in mice and patients indicate that liver metastasis restrains immunotherapy efficacy via macrophage-mediated T…