It has been reported (https://t.co/1VsvYpGXRU) that liver metastasis restrains immunotherapy efficacy, we look forward to an ongoing trial from @_beam_On and U of M to see if ablation of liver metastases can improve immunotherapy responses, NCT05430009.
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination. 研究人员发现肝转移肿瘤能够改变肿瘤免疫微环境,将全身的CD8+T细胞“吸”到肝脏中,并让它们发生凋亡,遏制抗肿瘤免疫和免疫治疗的效果. https://t.co/rGA7jBSWdT
@MathieuSpaas @JAMAOnc Also visceral metastases (eg, liver) seem to hinder the efficacy of immunotherapy: https://t.co/eGAi9F6K9U
@Dreesenkl This paper might explain where I’m coming from…IO therapies have not been looked at in mss crc in patients w/o liver mets. Liver mets crush IO efficacy. So is bot/bal really differentiated or is trial just selecting for better patients? https://
@ArndtVogel @JAMANetworkOpen @myESMO Liver is an ICI sink from macrophage induced T cell elimination. Wonder whether CD 47 mAbs combos will work better https://t.co/ZlQ2RVstyn
@pashtoonkasi @aparna1024 @sepideh_gholami @OncoAlert Liver directed therapy + IO maybe the way to go . Wonder how IO works pretty decent in HCC https://t.co/ATAjwwtgki
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination https://t.co/l84p1e0k7q
@Benjohnson1112 @MDAndersonNews @skopetz Seems relevant to you discrepancy…https://t.co/gB96xsLWnP
RT @TerekAdrian: @ArndtVogel @myESMO @OncoAlert With what was seen in subgroups in regonivo and now the 0% response rate in liver met+ vs 4…
@ArndtVogel @myESMO @OncoAlert With what was seen in subgroups in regonivo and now the 0% response rate in liver met+ vs 42% in liver met-, pts, its becoming clearer by the day. These are interesting. https://t.co/IrLudRQUqh https://t.co/vvzgojAS7J
#DYK? Patients with #livermetastases often receive little benefit from treatments like #immunotherapy. Learn more about the challenges associated with treating this type of #cancer in @NatureMedicine: https://t.co/jLQQk0jmBC https://t.co/JQEQSFBHME
RT @NatureMedicine: #Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but t…
RT @NatureMedicine: #Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but t…
RT @NatureMedicine: #Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but t…
#Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but therapeutic benefit can be improved by combining with liver-directed #radiotherapy #metastasis #macrophages @UMichSurgery @umichmedicine h
RT @surgeonscie: @drymtn @OHSUKnight Yes, the liver is a special place relative to immune homeostasis and antitumor immunity: https://t.co/…
@drymtn @OHSUKnight Yes, the liver is a special place relative to immune homeostasis and antitumor immunity: https://t.co/OGlQa2HC8l (for example). However, more cohort based characterization of 'immune signatures' and 'landscapes' aren't change treatment
RT @TriSalusLifeSci: A recent study notes patients with #liver metastases receiving #immunotherapy had lower overall survival rates than pa…
A recent study notes patients with #liver metastases receiving #immunotherapy had lower overall survival rates than patients with metastases in other organs. We must continue advancing the treatment paradigm to improve patients’ lives. https://t.co/GgJASN0
#DYK? Patients with #liver metastases often receive little benefit from treatments like #immunotherapy. Learn more about the challenges associated with treating this type of #cancer in @NatureMedicine: https://t.co/PCjn63czH5 https://t.co/7ulG7VPHOu
RT @Ablate_Cancer: Thus, liver metastases co-opt host peripheral tolerance mechanisms to cause acquired immunotherapy resistance through CD…
Thus, liver metastases co-opt host peripheral tolerance mechanisms to cause acquired immunotherapy resistance through CD8+ T cell deletion, and the combination of liver-directed radiotherapy and immunotherapy could promote systemic antitumor immunity. http
RT @AndresFCardonaZ: Published: 04 January 2021 Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell eliminatio…
RT @AndresFCardonaZ: Published: 04 January 2021 Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell eliminatio…
Published: 04 January 2021 Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination https://t.co/csD3kFEESJ
RT @ljpally19: Liver metastases (in melanoma) co-opt liver immune tolerance & 'siphon' off anti-tumour #Tcells & trigger their apoptosis (d…
RT @ljpally19: Liver metastases (in melanoma) co-opt liver immune tolerance & 'siphon' off anti-tumour #Tcells & trigger their apoptosis (d…
RT @ljpally19: Liver metastases (in melanoma) co-opt liver immune tolerance & 'siphon' off anti-tumour #Tcells & trigger their apoptosis (d…
Liver metastases (in melanoma) co-opt liver immune tolerance & 'siphon' off anti-tumour #Tcells & trigger their apoptosis (driven by monocyte-derived macrophages) causing immunotherapy resistance https://t.co/mcEPbagTDB #ILC2021 #livertwitter #jo
@EmilienLrd @SumeraIlyasMD
RT @jitcancer: June @sitcancer #JITC Editor reading list Dr Weber @nyulangone #4 @NatureMedicine Liver mets restrains immunotherapy via mac…
RT @jitcancer: June @sitcancer #JITC Editor reading list Dr Weber @nyulangone #4 @NatureMedicine Liver mets restrains immunotherapy via mac…
RT @jitcancer: June @sitcancer #JITC Editor reading list Dr Weber @nyulangone #4 @NatureMedicine Liver mets restrains immunotherapy via mac…
June @sitcancer #JITC Editor reading list Dr Weber @nyulangone #4 @NatureMedicine Liver mets restrains immunotherapy via macrophage-mediated T cell elimination - Great paper from Dr's Yu, Green & Zhou @umichmedicine https://t.co/ZdVjxS15Ku https://t.co
RT @marcvs_avrelivs: ¿Importa dónde están las metástasis para el pronóstico y la respuesta al tratamiento del cáncer? Este interesante art…
RT @marcvs_avrelivs: ¿Importa dónde están las metástasis para el pronóstico y la respuesta al tratamiento del cáncer? Este interesante art…
@BeckiLee Agreed! also this one: https://t.co/9NgoFn8o4u
RT @Ablate_Cancer: Thus, liver metastases co-opt host peripheral tolerance mechanisms to cause acquired immunotherapy resistance through CD…
RT @marcvs_avrelivs: ¿Importa dónde están las metástasis para el pronóstico y la respuesta al tratamiento del cáncer? Este interesante art…
RT @marcvs_avrelivs: ¿Importa dónde están las metástasis para el pronóstico y la respuesta al tratamiento del cáncer? Este interesante art…
RT @marcvs_avrelivs: ¿Importa dónde están las metástasis para el pronóstico y la respuesta al tratamiento del cáncer? Este interesante art…
RT @marcvs_avrelivs: ¿Importa dónde están las metástasis para el pronóstico y la respuesta al tratamiento del cáncer? Este interesante art…
Thus, liver metastases co-opt host peripheral tolerance mechanisms to cause acquired immunotherapy resistance through CD8+ T cell deletion, and the combination of liver-directed radiotherapy and immunotherapy could promote systemic antitumor immunity https
RT @marcvs_avrelivs: ¿Importa dónde están las metástasis para el pronóstico y la respuesta al tratamiento del cáncer? Este interesante art…
RT @marcvs_avrelivs: ¿Importa dónde están las metástasis para el pronóstico y la respuesta al tratamiento del cáncer? Este interesante art…
RT @marcvs_avrelivs: ¿Importa dónde están las metástasis para el pronóstico y la respuesta al tratamiento del cáncer? Este interesante art…
RT @marcvs_avrelivs: ¿Importa dónde están las metástasis para el pronóstico y la respuesta al tratamiento del cáncer? Este interesante art…
RT @marcvs_avrelivs: ¿Importa dónde están las metástasis para el pronóstico y la respuesta al tratamiento del cáncer? Este interesante art…
¿Importa dónde están las metástasis para el pronóstico y la respuesta al tratamiento del cáncer? Este interesante artículo publicado en @NatureMedicine parece indicar que sí y propone una solución a este problema. @WeTweetScienceM https://t.co/jJkdOITM
RT @BenCreelan: Do patients w/ liver mets do worse with IO? This report finds depletion of T cells by liver resident macrophages. Forgot al…
Do patients w/ liver mets do worse with IO? This report finds depletion of T cells by liver resident macrophages. Forgot all about Kupffer cells, now they matter. 👉https://t.co/qe3UwnyRcQ @NatureMedicine @UMRogelCancer https://t.co/mI55qAI2Zl
肝转移通过巨噬细胞介导的T细胞消除抑制免疫疗法的疗效 https://t.co/hxtpnlrHHA
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells @UMic…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells @UMic…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells @UMic…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells @UMic…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells @UMic…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells @UMic…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells @UMic…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells @UMic…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells @UMic…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells @UMic…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells @UMic…
Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells @UMichSurgery @UMRogelCancer @umichmedicine #metastasis #macrophages #coloncancer #ColorectalCancerAwarenessMonth https://t.co/4pPIt5vKLG
RT @VI4Research: 3️⃣Third #VI4RecReading of the month shows that combining #radiotherapy and #immunotherapy could improve patient outcomes…
3️⃣Third #VI4RecReading of the month shows that combining #radiotherapy and #immunotherapy could improve patient outcomes in metastatic #livercancer ⬇️⬇️ 📖: https://t.co/wWAgczsUki in @NatureMedicine 🧠: @_Beam_On @UMichSurgery @UMRogelCancer 🗣️: @FerrellL
@MurgataER det här bolaget saknar ju helt kraft i styrningen. Prospektet i samband med emissionen lövtunn. Klinisk plan oklar. Det finns ju potential att skapa en riktig story här med fokus på lever metastaser som systemtiskt hindrande för I/O effekt https
A very interesting read @NatureMedicine 'liver metastasis but not metastasis to other organs' is associated with reduced response to immunotherapy' https://t.co/3eT6CPUk08 and 'macs in the middle' https://t.co/fQHrgGIY03
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @FilippoMontemu1: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination https://t.co/OCC8japXOa…
RT @FilippoMontemu1: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination https://t.co/OCC8japXOa…
RT @FilippoMontemu1: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination https://t.co/OCC8japXOa…
RT @FilippoMontemu1: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination https://t.co/OCC8japXOa…
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination https://t.co/OCC8japXOa This paper is very cool and provides insights into reduced response to ICI in pts with liver metastases
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination https://t.co/18lmRji3Z5
still thinking about this weeks later. i want to see these trials! https://t.co/jCyr8oSiwX https://t.co/WZ1uWE2XVb
Fascinating paper shared by a friend with clinical implications on efficacy of IO in presence of hepatic metastases & potential role of RT in reversing immunosuppressive phenotype https://t.co/yP600VtSZd @QuezadaLab @gwalls89 @fifimcdrmh @gcgstewart
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @maini_lab: The liver induces local & systemic immune tolerance Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcell…
RT @HolabUnil: T cell graveyard! Let’s see what we can do to make it become T cell wonderland🤪
Fascinating study! Liver metastases (in melanoma patients) 'siphon' off anti-tumour #Tcells & trigger their apoptosis (driven by monocyte-derived macrophages) | Nature Medicine https://t.co/2WvTGP6kE5
RT @hotirishmonkey: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://…
@ClionaOfarrelly
RT @hotirishmonkey: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://…
RT @hotirishmonkey: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://…
RT @hotirishmonkey: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://…
RT @hotirishmonkey: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://…