RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @DrEzraCohen: Patients with liver metastases demonstrate lower efficacy to immune checkpoint blockade. One potential mechanism is relate…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
Patients with liver metastases demonstrate lower efficacy to immune checkpoint blockade. One potential mechanism is related to macrophages contained within those lesions which is targetable. https://t.co/o1SHpSmNo6
RT @drjamesgood: Liver mets are immunosuppressive, and radiotherapy could reverse this👇
RT @drjamesgood: Liver mets are immunosuppressive, and radiotherapy could reverse this👇
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @drjamesgood: Liver mets are immunosuppressive, and radiotherapy could reverse this👇
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @IdoAmitLab: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co…
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination https://t.co/dUZrMhj69B
RT @IdoAmitLab: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
Liver metastases induce systemic tumor-specific CD8+ T cell loss and abrogate immunotherapy efficacy in preclinical models, which mirrors the systemic T cell loss and diminished immunotherapy efficacy observed in patients with liver metastases https://t.co
RT @OncoRod: Nuevos datos fortalecen la necesidad de continuar investigando la combinación de radioterapia con inmunoterapia👏🏼👏🏼💪🏼‼️ ✅RT-I…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
"In this paper, liver metastases siphon activated CD8+ T cells from systemic circulation & macrophages in the liver promote T cell elimination creating thus an immune desert." @ClionaOfarrelly @CathalHarmon
Great study! Likely similar factors at play in advanced primary liver malignancies. Will be interesting to see outcomes of numerous ongoing Phase II/III trials combining ICI with LRT for unresectable #HCC
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
This is truly remarkable! After digging the paper, I’ll probably come up with millions of questions. Bookmarked ✅ I hope this will help patients with PDAC whose tumors are irresponsive to ICBs. Fun fact : This paper reminds me carcinoid syndrome-liver meta
RT @oncologician: Liver metastases co-opt host peripheral tolerance mechanisms to cause acquired immunotherapy resistance through CD8+ T ce…
RT @oncologician: Liver metastases co-opt host peripheral tolerance mechanisms to cause acquired immunotherapy resistance through CD8+ T ce…
Liver metastases co-opt host peripheral tolerance mechanisms to cause acquired immunotherapy resistance through CD8+ T cell deletion, and the combination of liver-directed radiotherapy and immunotherapy could promote systemic antitumor immunity.
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination https://t.co/3TkpeSe7Ex https://t.co/L42SxFBwrE
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+ T cells from systemic circulation & macrophages in the liver promote T cell elimination creating thus an immune desert. https:
RT @Johanna_A_Joyce: Fascinating new #TumorMicroenvironment study in @NatureMedicine Liver metastases siphon activated CD8+ T cells from th…
RT @UMRogelCancer: ICYMI: a new #RogelCancer study in @NatureCancer explains why patients with #cancer spread to the liver have worse outco…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @CGrassberger: 🚨 liver mets and their systemic effect on immunity! when we observed years ago that irradiating liver mets was more “imm…
ICYMI: a new #RogelCancer study in @NatureCancer explains why patients with #cancer spread to the liver have worse outcomes.
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @nijuoti: なかなか興味深い提案 https://t.co/9jiVylpcrJ
なかなか興味深い提案
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @IdoAmitLab: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
Super interesting
RT @CGrassberger: 🚨 liver mets and their systemic effect on immunity! when we observed years ago that irradiating liver mets was more “imm…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
🚨 liver mets and their systemic effect on immunity! when we observed years ago that irradiating liver mets was more “immunogenic”, maybe all we saw was that they’re simply more immunosuppressive when they’re around? @StevenLin_MDPhD @HIY_RadOnc_YCC htt
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @drjamesgood: Liver mets are immunosuppressive, and radiotherapy could reverse this👇
RT @IdoAmitLab: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co…
RT @IdoAmitLab: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @Johanna_A_Joyce: Fascinating new #TumorMicroenvironment study in @NatureMedicine Liver metastases siphon activated CD8+ T cells from th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @drjamesgood: Liver mets are immunosuppressive, and radiotherapy could reverse this👇
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @DrYukselUrun: 🔶Liver metastases create a systemic immune desert in preclinical models! 🔶Liver-directed ☢️ eliminates immunosuppressive…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @MustafaRaoofMD: Really nice pre-clinical work suggesting liver directed therapy for liver mets across cancer types may improve immunoth…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @IdoAmitLab: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @drjamesgood: Liver mets are immunosuppressive, and radiotherapy could reverse this👇 https://t.co/QGzVHnlsNm
RT @drjamesgood: Liver mets are immunosuppressive, and radiotherapy could reverse this👇
Liver mets are immunosuppressive, and radiotherapy could reverse this👇
RT @Johanna_A_Joyce: Fascinating new #TumorMicroenvironment study in @NatureMedicine Liver metastases siphon activated CD8+ T cells from th…
Nuevos datos fortalecen la necesidad de continuar investigando la combinación de radioterapia con inmunoterapia👏🏼👏🏼💪🏼‼️ ✅RT-IO con beneficio terapéutico en metástasis hepaticas 👊🏻 @delvysra @Dr_Ivanoncologo @SEOR_ESP @Tony_Calles
RT @IdoAmitLab: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co…
RT @Johanna_A_Joyce: Fascinating new #TumorMicroenvironment study in @NatureMedicine Liver metastases siphon activated CD8+ T cells from th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
Very good one!
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @IdoAmitLab: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @DrYukselUrun: 🔶Liver metastases create a systemic immune desert in preclinical models! 🔶Liver-directed ☢️ eliminates immunosuppressive…
RT @DrYukselUrun: 🔶Liver metastases create a systemic immune desert in preclinical models! 🔶Liver-directed ☢️ eliminates immunosuppressive…
RT @IdoAmitLab: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co…
RT @DrYukselUrun: 🔶Liver metastases create a systemic immune desert in preclinical models! 🔶Liver-directed ☢️ eliminates immunosuppressive…
RT @DrYukselUrun: 🔶Liver metastases create a systemic immune desert in preclinical models! 🔶Liver-directed ☢️ eliminates immunosuppressive…
Liver metastasis co-opt liver tolerance mechanisms to limit systemic anti tumour immune responses! The big challenge of liver cancer
RT @IdoAmitLab: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co…
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co/RC97kBbsZr
RT @DrYukselUrun: 🔶Liver metastases create a systemic immune desert in preclinical models! 🔶Liver-directed ☢️ eliminates immunosuppressive…
RT @DrYukselUrun: 🔶Liver metastases create a systemic immune desert in preclinical models! 🔶Liver-directed ☢️ eliminates immunosuppressive…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @DrYukselUrun: 🔶Liver metastases create a systemic immune desert in preclinical models! 🔶Liver-directed ☢️ eliminates immunosuppressive…