RT @JAX_CKB: Interesting study shows liver metastasis is associated with acquired #immunotherapy resistance via deletion of CD8+T cells. #c…
RT @JAX_CKB: Interesting study shows liver metastasis is associated with acquired #immunotherapy resistance via deletion of CD8+T cells. #c…
Interesting study shows liver metastasis is associated with acquired #immunotherapy resistance via deletion of CD8+T cells. #cancerresearch #immunesystem
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
Trending on PubMed: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination. https://t.co/Veqnd7CrO5
RT @CGrassberger: 🚨 liver mets and their systemic effect on immunity! when we observed years ago that irradiating liver mets was more “imm…
RT @NatRevClinOncol: Studies in mice and patients indicate that liver metastasis restrains immunotherapy efficacy via macrophage-mediated T…
I am fascinated. Thinking back to my patients with liver mets, the extent of disease, their response to immunotherapy & the timing of liver-directed RT. Lots to consider in this potential approach
RT @NatRevClinOncol: Studies in mice and patients indicate that liver metastasis restrains immunotherapy efficacy via macrophage-mediated T…
RT @NatRevClinOncol: Studies in mice and patients indicate that liver metastasis restrains immunotherapy efficacy via macrophage-mediated T…
RT @NatRevClinOncol: Studies in mice and patients indicate that liver metastasis restrains immunotherapy efficacy via macrophage-mediated T…
Nat Med 腫瘍が肝臓に転移すると、CD8+ T細胞を吸い上げて(siphon)、がん免疫療法の効果を妨げている 肝臓の転移巣を標的とする対策が必要ということか。 https://t.co/mjUkTF9Trd
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatRevClinOncol: Studies in mice and patients indicate that liver metastasis restrains immunotherapy efficacy via macrophage-mediated T…
RT @CyrilPedia: 'It is not clear whether liver immune tolerance mechanisms contribute to cancer outcomes. We report that liver metastases d…
RT @IdoAmitLab: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co…
@CharuAggarwalMD @PennCancer @LovaSunMD @Jbauml @ATB_MD @MMarmarelis @CoreyLangerMD What about liver mets ? https://t.co/V9LU7GRqNO https://t.co/6u96bHSbte
RT @CyrilPedia: 'It is not clear whether liver immune tolerance mechanisms contribute to cancer outcomes. We report that liver metastases d…
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co/KFN4w1kU60
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co/uRPw6e6Udw
RT @NatRevClinOncol: Studies in mice and patients indicate that liver metastasis restrains immunotherapy efficacy via macrophage-mediated T…
"Within the liver, activated antigen-specific Fas+CD8+ T cells undergo apoptosis following their interaction with FasL+CD11b+F4/80+ monocyte-derived macrophages. Consequently, liver metastases create a systemic immune desert in preclinical models."
RT @NatRevClinOncol: Studies in mice and patients indicate that liver metastasis restrains immunotherapy efficacy via macrophage-mediated T…
Liver metastases co-opt host peripheral tolerance mechanisms to "siphon" activated CD8+ T cells from systemic circulation, creating a "systemic immune desert" and diminishing efficacy of anti-cancer immunotherapy.
Liver mets increase monocyte-derived macrophages that kill T-cells and thereby decrease effectiveness of immunotherapy.
RT @NatRevClinOncol: Studies in mice and patients indicate that liver metastasis restrains immunotherapy efficacy via macrophage-mediated T…
'It is not clear whether liver immune tolerance mechanisms contribute to cancer outcomes. We report that liver metastases diminish immunotherapy efficacy systemically in patients and preclinical models' https://t.co/7z76Qa5kV8
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination https://t.co/KzobdWcwih https://t.co/XyPxoC4c9z
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co/REzkSueHcm
RT @NatRevClinOncol: Studies in mice and patients indicate that liver metastasis restrains immunotherapy efficacy via macrophage-mediated T…
RT @NatRevClinOncol: Studies in mice and patients indicate that liver metastasis restrains immunotherapy efficacy via macrophage-mediated T…
Studies in mice and patients indicate that liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination, reducing systemic T cell numbers; this effect could be reduced in mice by treating liver mets with radiotherapy: https:
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @CJTsaiMDPhD: 🚨Liver #metastasis⬇️antigen-specific T cells,⬆️T cell apoptosis,⬇️#immunotherapy efficacy. ☢️#Radiotherapy⬆️T-cell immuni…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co/y5X6aukr2P
RT @humanimmunenews: 🥼 Drs. Jiali Yu and Michael Green, along with their teams at @UMRogelCancer report that liver metastases diminish #imm…
🥼 Drs. Jiali Yu and Michael Green, along with their teams at @UMRogelCancer report that liver metastases diminish #immunotherapy efficacy systemically in patients and preclinical models. @NatureMedicine | https://t.co/FMZngTF0Vw https://t.co/VUICozgGXd
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination. https://t.co/9siPeY0sQz https://t.co/r2mNSnxzCh
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @Johanna_A_Joyce: Fascinating new #TumorMicroenvironment study in @NatureMedicine Liver metastases siphon activated CD8+ T cells from th…
RT @AndresFCardonaZ: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination https://t.co/csD3kFEESJ
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @AndresFCardonaZ: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination https://t.co/csD3kFEESJ
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @AndresFCardonaZ: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination https://t.co/csD3kFEESJ
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @IdoAmitLab: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @MayCho_MD: @mgfakih kept showing it in CRC liver Mets! @jgong15
RT @CJTsaiMDPhD: 🚨Liver #metastasis⬇️antigen-specific T cells,⬆️T cell apoptosis,⬇️#immunotherapy efficacy. ☢️#Radiotherapy⬆️T-cell immuni…
🚨Liver #metastasis⬇️antigen-specific T cells,⬆️T cell apoptosis,⬇️#immunotherapy efficacy. ☢️#Radiotherapy⬆️T-cell immunity in liver,⬇️ immunotherapy resistance induced by liver metastasis. Implication for early liver-directed RT? Timing of RT/dose? Hi
@mgfakih kept showing it in CRC liver Mets! @jgong15
RT @DrEzraCohen: Patients with liver metastases demonstrate lower efficacy to immune checkpoint blockade. One potential mechanism is relate…
RT @CGrassberger: 🚨 liver mets and their systemic effect on immunity! when we observed years ago that irradiating liver mets was more “imm…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @IdoAmitLab: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co…
RT @IamLinghua: An interesting study showing that liver metastases siphon and eliminate antigen-specific CD8+ T cells, leading to systemic…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
An interesting study showing that liver metastases siphon and eliminate antigen-specific CD8+ T cells, leading to systemic immunosuppression.
RT @Caldera60373705: Immunosuppressive role of liver metastases https://t.co/H1A59T7smW
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @IdoAmitLab: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co…
Excellent work!!! Congratulations to the authors!!!!👏👏👏 https://t.co/yA71ICVspu
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination https://t.co/csD3kFEESJ
RT @CGrassberger: 🚨 liver mets and their systemic effect on immunity! when we observed years ago that irradiating liver mets was more “imm…
RT @Johanna_A_Joyce: Fascinating new #TumorMicroenvironment study in @NatureMedicine Liver metastases siphon activated CD8+ T cells from th…
A posible mechanism to explicate liver metastases induced immune tolerance https://t.co/FWjD6lVn2y
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @Johanna_A_Joyce: Fascinating new #TumorMicroenvironment study in @NatureMedicine Liver metastases siphon activated CD8+ T cells from th…
Role of liver metastasis and tissue resident macrophages on restraining anti-PD-L1 efficacy | Nature Medicine https://t.co/ayly7anm4c
RT @CGrassberger: 🚨 liver mets and their systemic effect on immunity! when we observed years ago that irradiating liver mets was more “imm…
RT @DrEzraCohen: Patients with liver metastases demonstrate lower efficacy to immune checkpoint blockade. One potential mechanism is relate…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @IdoAmitLab: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @NatureMedicine: Liver metastases reduce #immunotherapy efficacy through hepatic siphoning of circulating activated CD8+ #Tcells, but th…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
RT @Eric_Vibert: Furthermore, association of #radiotherapy and immune checkpoint inhibitor is the key. External or Internal radiotherapy is…
Furthermore, association of #radiotherapy and immune checkpoint inhibitor is the key. External or Internal radiotherapy is the future of oncology in association with IOC, nanoparticules and liver surgery @CHBPaulBrousse @GustaveRoussy @APHP @laliguecancer
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | @NatureMedicine https://t.co/DC7cedzIeO
RT @IdoAmitLab: Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination | Nature Medicine https://t.co…
RT @jsoriamd: Patients with liver metastasis derive less benefit from #immunotherapy. In this paper, liver metastases siphon activated CD8+…
Immunosuppressive role of liver metastases https://t.co/H1A59T7smW