RT @timothygirard: To all of my colleagues who devoted more than a decade of hard work to this clinical trial, I'm incredibly grateful. htt…
RT @ADAlthousePhD: To all you #openscience advocates, in the spirit of positive reinforcement, might I suggest that you take a moment to co…
I'm curious about the effects on QoL w/wo antipsychotics esp post-ICU stay.
RT @dokterJes: Geen effect van haldol of ziprasidone bij behandeling van (vooral hypoactief) delier op IC tov placebo. https://t.co/g1GBRBG…
RT @ADAlthousePhD: To all you #openscience advocates, in the spirit of positive reinforcement, might I suggest that you take a moment to co…
RT @NEJM: Original Article: Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness (MIND-USA) https://t.co/nyMtikjMDC E…
RT @aluetz: I do consider them only when ICU pts have persistent hallucinations - independently of being CAM-ICU pos/neg. https://t.co/9qE0…
RT @medevidenceblog: Delirium is an epiphenomenon of illness till proved otherwise, and without an elaborated causal mechanism there is no…
RT @Cunningham_Colm: Important study from @timothygirard but also sympathy for point made by @medevidenceblog . #delirium patients have alt…
RT @medevidenceblog: Delirium is an epiphenomenon of illness till proved otherwise, and without an elaborated causal mechanism there is no…
Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness | NEJM https://t.co/A6bhdAdMjg
Two commonly used antipsychotic drugs not successful when treating delirium in ICU patients https://t.co/B5cPJUqOR3
I do consider them only when ICU pts have persistent hallucinations - independently of being CAM-ICU pos/neg.
RT @medevidenceblog: Delirium is an epiphenomenon of illness till proved otherwise, and without an elaborated causal mechanism there is no…
RT @DrOChaudhary: Precedex for everyone! No, but seriously this may be a paradigm shift in delirium management. Time to implement all those…
RT @Cunningham_Colm: Important study from @timothygirard but also sympathy for point made by @medevidenceblog . #delirium patients have alt…
RT @ADAlthousePhD: To all you #openscience advocates, in the spirit of positive reinforcement, might I suggest that you take a moment to co…
Study: #Antipsychotic drugs don't ease #ICU delirium or #dementia. via @NPRHealth https://t.co/6WNFK5ZY0W Read the study @NEJM here: https://t.co/vByaJdGNIu https://t.co/oEzfwrHhyh
RT @accpcritprn: *NEW* MIND-USA Does the use of haloperidol or ziprasidone impact the duration of delirium in critically-ill? #critPRN #AC…
RT @timothygirard: To all of my colleagues who devoted more than a decade of hard work to this clinical trial, I'm incredibly grateful. htt…
RT @dtmaust: In today's edition of things I learned in residency that are not true, thanks to @timothygirard: Haloperidol and Ziprasidone…
If you refuse healthcare to non English speakers, that’s discrimination: if you refuse to enroll people in research for non English speakers, that’s discrimination. Please call out this whenever you discuss a study, review grant or IRB applications.
Kudos. Big steps forward.
RT @virenkaul: Best thing to do for #delirium in ICU? Prevent it by: ☄️Minimizing sedatives 💊regularly reviewing meds on board 🚶🏽♂️Easy…
RT @timothygirard: To all of my colleagues who devoted more than a decade of hard work to this clinical trial, I'm incredibly grateful. htt…
Drugs don't work for ICU delirium per RCT reported in @nejm. Remarkably, among pts not previously psychotic or demented, 48% had delirium! They excluded non-English speakers (WHY? Because of research discrimination!), which make this % an underestimate. h
RT @dtmaust: In today's edition of things I learned in residency that are not true, thanks to @timothygirard: Haloperidol and Ziprasidone…
RT @anesthesianews: Haloperidol and Ziprasidone Ineffective for Treatment of Delirium in the ICU #NEJM https://t.co/ZRfHWpFGMM
Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness | NEJM https://t.co/XcYz3YJIhL
In today's edition of things I learned in residency that are not true, thanks to @timothygirard: Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness https://t.co/9LCkTKouom https://t.co/8RfZq3bEC3
Haloperidol and Ziprasidone Ineffective for Treatment of Delirium in the ICU #NEJM https://t.co/49R7LE5CNu
Haloperidol and Ziprasidone Ineffective for Treatment of Delirium in the ICU #NEJM https://t.co/ZRfHWpFGMM
RT @timothygirard: To all of my colleagues who devoted more than a decade of hard work to this clinical trial, I'm incredibly grateful. htt…
Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness | NEJM https://t.co/vz9Xn6jhDH
RT @timothygirard: To all of my colleagues who devoted more than a decade of hard work to this clinical trial, I'm incredibly grateful. htt…
RT @ADAlthousePhD: Massive congratulations to @PittCCM's @timothygirard for publishing the MIND-USA trial in @NEJM. At a glance looked lik…
RT @NEJM: Original Article: Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness (MIND-USA) https://t.co/nyMtikjMDC E…
RT @Cunningham_Colm: Important study from @timothygirard but also sympathy for point made by @medevidenceblog . #delirium patients have alt…
RT @dokterJes: Geen effect van haldol of ziprasidone bij behandeling van (vooral hypoactief) delier op IC tov placebo. https://t.co/g1GBRBG…
RT @ADAlthousePhD: To all you #openscience advocates, in the spirit of positive reinforcement, might I suggest that you take a moment to co…
RT @kathy_y_liu: My (limited) experience ->many patients in ITU receive substantial doses of these drugs for delirium. This study shows no…
RT @NEJM: Original Article: Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness (MIND-USA) https://t.co/nyMtikjMDC E…
Should we treat delirium in the ICU? Food for thought.
RT @timothygirard: To all of my colleagues who devoted more than a decade of hard work to this clinical trial, I'm incredibly grateful. htt…
https://t.co/FQtzIURa5w Antipsychotics used to manage delerium in an ICU are not really meant to improve delerium as much as to decrease agitation using relatively safe drug. Seems these researchers were looking for the wrong result-and used very high drug
RT @ADAlthousePhD: To all you #openscience advocates, in the spirit of positive reinforcement, might I suggest that you take a moment to co…
Important stuff. Anyone aware of this type of findings for paediatric delirium?
RT @Cunningham_Colm: Important study from @timothygirard but also sympathy for point made by @medevidenceblog . #delirium patients have alt…
RT @timothygirard: To all of my colleagues who devoted more than a decade of hard work to this clinical trial, I'm incredibly grateful. htt…
RT @NakayamaYujiro: このような「有意差なし」の論文はかなりの人が誤った解釈をする。 →「有意差なしなのだから、抗精神病薬はせん妄に無効なのだ」 正しくは →「有意差なしなので、本研究からは抗精神病薬がせん妄に有効かどうかは不明」 です。 https://…
RT @NakayamaYujiro: このような「有意差なし」の論文はかなりの人が誤った解釈をする。 →「有意差なしなのだから、抗精神病薬はせん妄に無効なのだ」 正しくは →「有意差なしなので、本研究からは抗精神病薬がせん妄に有効かどうかは不明」 です。 https://…
Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness | NEJM https://t.co/979XLTkeYS
RT @NEJM: Original Article: Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness (MIND-USA) https://t.co/nyMtikjMDC E…
RT @kathy_y_liu: My (limited) experience ->many patients in ITU receive substantial doses of these drugs for delirium. This study shows no…
RT @docterskywalker: Data that’s welcome up on my soapbox: Antipsychotics don’t work for treating ICU delirium. I only consider them when…
Conclusion? Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness | NEJM https://t.co/vX4edlQ3ZM
RT @jent103: It's an exciting day at the office: Our MIND-USA trial, showing no evidence of benefit (or major harm) from two antipsychotics…
RT @ADAlthousePhD: To all you #openscience advocates, in the spirit of positive reinforcement, might I suggest that you take a moment to co…
RT @NEJM: Original Article: Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness (MIND-USA) https://t.co/nyMtikjMDC E…
It's time doctors start paying attention to the literature and focus on #personcenteredcare and #geriatrics
RT @virenkaul: Best thing to do for #delirium in ICU? Prevent it by: ☄️Minimizing sedatives 💊regularly reviewing meds on board 🚶🏽♂️Easy…
RT @ADAlthousePhD: To all you #openscience advocates, in the spirit of positive reinforcement, might I suggest that you take a moment to co…
RT @jent103: It's an exciting day at the office: Our MIND-USA trial, showing no evidence of benefit (or major harm) from two antipsychotics…
RT @virenkaul: Best thing to do for #delirium in ICU? Prevent it by: ☄️Minimizing sedatives 💊regularly reviewing meds on board 🚶🏽♂️Easy…
RT @virenkaul: Best thing to do for #delirium in ICU? Prevent it by: ☄️Minimizing sedatives 💊regularly reviewing meds on board 🚶🏽♂️Easy…
@amynbjohnston1 seen this
RT @ADAlthousePhD: To all you #openscience advocates, in the spirit of positive reinforcement, might I suggest that you take a moment to co…
RT @timothygirard: To all of my colleagues who devoted more than a decade of hard work to this clinical trial, I'm incredibly grateful. htt…
It’s really challenging to do a RCT in icu. Hence we lack good quality evidence for many interventions. Yet we continue to do them.
Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness | NEJM https://t.co/7eQGfoOLWW
Haloperidol and Ziprasidone did not alter significantly the duration of Delirium in Critical Illness | NEJM https://t.co/N7FlB7Poko
あらためて、抗精神病薬はせん妄に無効。薬剤による行動制限に過ぎない
Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness | NEJM https://t.co/ZvvwdRxR16
RT @tompollak: More evidence against the use of antipsychotics in delirium. https://t.co/rPS4iUY8nx
RT @timothygirard: An article I and others published in @NEJM today has received some attention on Twitter. Of my tweets thus far about the…
RT @ADAlthousePhD: To all you #openscience advocates, in the spirit of positive reinforcement, might I suggest that you take a moment to co…
Nice study putting the nail in the coffin for icu delirium treatment with antipsychotics. But, what should best practice be to treat agitation after exhausting non-pharmacologic interventions?
RT @ADAlthousePhD: To all you #openscience advocates, in the spirit of positive reinforcement, might I suggest that you take a moment to co…
To all you #openscience advocates, in the spirit of positive reinforcement, might I suggest that you take a moment to compliment the MIND-USA (https://t.co/PNN1HIGWoA) trial team for publicly posting their SAP, code, and data here: https://t.co/00GE0qgq5W
RT @tompollak: More evidence against the use of antipsychotics in delirium. https://t.co/rPS4iUY8nx
Antipsychotics show no effect on duration of #ICU delirium @NEJM #CriticalCare #FOAMed https://t.co/2GjZrUFmYd
RT @timothygirard: To all of my colleagues who devoted more than a decade of hard work to this clinical trial, I'm incredibly grateful. htt…
RT @timothygirard: To all of my colleagues who devoted more than a decade of hard work to this clinical trial, I'm incredibly grateful. htt…
To REALLY understand what happened in this trial, a mixed methods arm needed for a qualitative analysis of how bedside #nurses/#RNs thought this ACTUALLY worked --> Haloperidol and Ziprasidone & Treatment of Delirium https://t.co/igRH0yiAi5 #NeedRNV
More evidence against the use of antipsychotics in delirium. https://t.co/rPS4iUY8nx
RT @NEJM: Original Article: Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness (MIND-USA) https://t.co/nyMtikjMDC E…
RT @medevidenceblog: Delirium is an epiphenomenon of illness till proved otherwise, and without an elaborated causal mechanism there is no…
Important study from @timothygirard but also sympathy for point made by @medevidenceblog . #delirium patients have altered consciousness but there is limited biological rationale for antipsychotics. Need to understand what's happening to brain in acute ill
Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness | NEJM https://t.co/wp5hMfDHko
RT @NEJM: Original Article: Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness (MIND-USA) https://t.co/nyMtikjMDC E…
RT @DanielJDrucker: Lack of Benefit for Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness | NEJM https://t.co/XWfiu…
Moot point, however, whether the lack of effect indicates a lack of involvement in dopamine signalling in delirium in ICU https://t.co/K870F8ia8c https://t.co/rkOQZlR62P
RT @Doc_Yogi: Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness | NEJM https://t.co/r6jtIcl4xW
RT @PICJournalWatch: #LIVES2018 #Trials #TARGET @ANZICSCORE https://t.co/zzQKeodTvK Energy dense no better #BREATHE @WarwickCTU @BacrUob…
RT @NakayamaYujiro: このような「有意差なし」の論文はかなりの人が誤った解釈をする。 →「有意差なしなのだから、抗精神病薬はせん妄に無効なのだ」 正しくは →「有意差なしなので、本研究からは抗精神病薬がせん妄に有効かどうかは不明」 です。 https://…
RT @NakayamaYujiro: 10/22NEJM) ICUのせん妄患者に抗精神病薬vsプラセボのRCT、過去最大サンプル数。結果は有意差なし。理由は1, せん妄はそもそも脳の問題じゃない可能性2, せん妄は色んなメカニズムがある。 Haloperidol and Z…
RT @NEJM: Original Article: Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness (MIND-USA) https://t.co/nyMtikjMDC E…
RT @NEJM: Original Article: Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness (MIND-USA) https://t.co/nyMtikjMDC E…