See also this on #Anacetrapib > Thanks all you experts. https://t.co/D7PheBbzJO
RT @skathire: in light CETP news, 2012 pub from lab which found: raising HDL - not helpful lowering LDL - (almost) always good https://t.co…
RT @skathire: in light CETP news, 2012 pub from lab which found: raising HDL - not helpful lowering LDL - (almost) always good https://t.co…
in light CETP news, 2012 pub from lab which found: raising HDL - not helpful lowering LDL - (almost) always good https://t.co/BBMUGJdrWH 1/ https://t.co/NuVZnCeat7
👌U read 2012 paper closely & got subtlety CETP variant raises HDL lot (worthless) & lowers LDL little (beneficial) https://t.co/rXB09iN2PZ https://t.co/kbHjEfEnQt
RT @adamjshay: @sciencescanner @DShaywitz actually not true - Mend Rand study DOES support CETP role in MI: http://t.co/T6cK2Rzcor , SNP rs…
RT @skathire: by the way, in our MR study HDL cholesterol 2012 (suggested HDL not causal), careful wording re CETP. 👇 https://t.co/bPe9kQe…
@DrMJoyner cf Table 2: https://t.co/zmbKQys2xu
RT @skathire: by the way, in our MR study HDL cholesterol 2012 (suggested HDL not causal), careful wording re CETP. 👇 https://t.co/bPe9kQe…
RT @skathire: by the way, in our MR study HDL cholesterol 2012 (suggested HDL not causal), careful wording re CETP. 👇 https://t.co/bPe9kQe…
RT @skathire: by the way, in our MR study HDL cholesterol 2012 (suggested HDL not causal), careful wording re CETP. 👇 https://t.co/bPe9kQe…
by the way, in our MR study HDL cholesterol 2012 (suggested HDL not causal), careful wording re CETP. 👇 https://t.co/bPe9kQeFFk https://t.co/3QtIYgfa1E
@jkpritch if limit 'core' genes to those w/ knockout alleles, would miss rate-limiting enzyme chol synthesis & best drug target all medicine https://t.co/uKyjyPX6us
@rplenge data HMGCR Bio effect variant: small change liver mRNA Clin effect variant: LDL, 2 mg/dl; CAD, OR 1.04 'core gene'? https://t.co/3NnV1vZUXq https://t.co/qay69U30Dc
@splon @CMichaelGibson Based on human genetics, this was our take on HDL in 2012. https://t.co/bPe9kQeFFk https://t.co/SMYSJI6bOH
@TuckerGoodrich @DrAseemMalhotra @pascalmeier74 Science isn't silly =) https://t.co/U5nrqZDbKl https://t.co/lsMKysqMVz
@DietHeartNews @patentbobm @tednaiman Mendelian randomization also says "don't count on it" https://t.co/69URlCidU9
RT @skathire: 6/n some papers on human genetics HDL, TG, and CHD https://t.co/bPe9kQeFFk https://t.co/6cfyxOMnD5
RT @skathire: 6/n some papers on human genetics HDL, TG, and CHD https://t.co/bPe9kQeFFk https://t.co/6cfyxOMnD5
RT @skathire: 6/n some papers on human genetics HDL, TG, and CHD https://t.co/bPe9kQeFFk https://t.co/6cfyxOMnD5
RT @skathire: 6/n some papers on human genetics HDL, TG, and CHD https://t.co/bPe9kQeFFk https://t.co/6cfyxOMnD5
RT @skathire: 6/n some papers on human genetics HDL, TG, and CHD https://t.co/bPe9kQeFFk https://t.co/6cfyxOMnD5
6/n some papers on human genetics HDL, TG, and CHD https://t.co/bPe9kQeFFk https://t.co/6cfyxOMnD5
@mendel_random References; genetics L (1SD LDL~35mg/dl); pharm R (1mmol x axis~39 mg/dl) https://t.co/rXB09j4Eez https://t.co/0Rj2vO0dR2 https://t.co/ihYeFvK1Ij
@Nutrevolve @cardiobrief And as I'm sure we all know by now, HDL-C is not causal in CVD: https://t.co/7lh3DK3kU6 https://t.co/cTaQuwlwc7
@PeterAttiaMD CETP and Niacin failures were big, but death blow was this from... https://t.co/jfStqcUKSg by #jcsouto via @c0nvey
RT @ethanjweiss: @PeterAttiaMD CETP and Niacin failures were big, but death blow was this from @skathire https://t.co/8aFrdfGyVS
RT @ethanjweiss: @PeterAttiaMD CETP and Niacin failures were big, but death blow was this from @skathire https://t.co/8aFrdfGyVS
RT @ethanjweiss: @PeterAttiaMD CETP and Niacin failures were big, but death blow was this from @skathire https://t.co/8aFrdfGyVS
RT @ethanjweiss: @PeterAttiaMD CETP and Niacin failures were big, but death blow was this from @skathire https://t.co/8aFrdfGyVS
RT @ethanjweiss: @PeterAttiaMD CETP and Niacin failures were big, but death blow was this from @skathire https://t.co/8aFrdfGyVS
@PeterAttiaMD CETP and Niacin failures were big, but death blow was this from @skathire https://t.co/8aFrdfGyVS
RT @skathire: @KentBottles @statnews carriers gene mut that increase HDL have same MI risk as those who don't carry mut (3/n) https://t.co/…
@KentBottles @statnews carriers gene mut that increase HDL have same MI risk as those who don't carry mut (3/n) https://t.co/bPe9kQwgwS
@CaloriesProper https://t.co/EukJLFJbiF https://t.co/jXkSsx73Ma These studies also strongly challenge the HDL-will-save-us idea
RT @adamcifu: Remember this study? There remains some doubt. https://t.co/buuIY86AAU https://t.co/KJly4RUtbA
Remember this study? There remains some doubt. https://t.co/buuIY86AAU https://t.co/KJly4RUtbA
@HealthyFellow Study https://t.co/QqScU0QMrP "Data CHALLENGE THE CONCEPT raising of HDL will uniformly translate into MI risk reductions."
@matthewherper @skathire SK Lancet paper showed evidence for CETP SNP on outcomes,but associated marker=LDL not HDL: http://t.co/DogbJhuym6
@ewanbirney @dgmacarthur Here's a mendelian randomization study, aslo showing a benefit for CETP variants http://t.co/WTPSbeW4bL
If protective effect of HDL is non-genetic, does that mean it's a more modifiable risk factor than LDL? http://t.co/EYP0f8YBWG
If protective effect of HDL is non-genetic, does that mean it's a more modifiable risk factor than LDL? http://t.co/EYP0f8YBWG
If protective effect of HDL is non-genetic, does that mean it's a more modifiable risk factor than LDL? http://t.co/EYP0f8YBWG
@billbarendse @AugustWeismann Thanks for that Bill - led me to this http://t.co/EYP0f8YBWG which seems to confirm HDL is modifiable factor.
.@livinlowcarbman @Drlipid CRP and HDL ref’s http://t.co/noBZt1l82P http://t.co/Ewm20lgO5e /2
@regeneron the difference? ldl is worth targeting http://t.co/WO2EGqqfMc
@FatEmperor @brianedwardsmd @livinlowcarbman @bigfatsurprise @ProfTimNoakes There's some pesky NATURAL genetics, too: http://t.co/TVoisyNPIy
@GeneralHealthy thanks! I believe those were his conclusions, but they're still debated: http://t.co/W9I8imz7PC, http://t.co/XQwx7Q5Tvh
In contrast, causal role of HDL-cholesterol in coronary heart disease is not so clear. See also: http://t.co/MmAv7IHimS
@sciencescanner @DShaywitz actually not true - Mend Rand study DOES support CETP role in MI: http://t.co/T6cK2Rzcor , SNP rs3764261
Plasma HDL cholesterol and myocardial infarction: a http://t.co/he95O8yMG4 Raising HDL cholesterol may not reduce risk of heart disease
HDL cholesterol and risk of myocardial infarction: a study http://t.co/he95O8yMG4 Biomarker modulated by genetic variant
@lingkui genetic support of LDL as causal: http://t.co/7XGI8iIxRO; lack of evidence for lowering TGs http://t.co/cWFUuNSemc
#PRC7 Wislar's researchers found one article in the Lancet that had 600+ authors! http://t.co/5PpwyNuOBw (cited 118 times btw)
#PRC7 Wislar's researchers found one article in the Lancet that had 600+ authors! http://t.co/5PpwyNuOBw (cited 118 times btw)
#ICanHazPDF The Lancet: "Plasma HDL cholesterol and risk..." http://t.co/6MGfuckX4s [twitter_handle] at [gmail]
Desafio HDL! Incremento genéticamente mediado de HDL no reduce riesgo de infarto. Randomización mendeliana http://t.co/ZPJN1nGpCp
5. Plasma HDL cholesterol and risk of myocardial infarction — http://t.co/qatkROH4vc #TBICRI13
Subir los niveles de HDL no implica reducción del riesgo coronario. La correlación no es causal. http://t.co/LnQO8IcV
@nujo0d the paper published in the top journal lancet, may2012. Check the link below. http://t.co/7n2olcUf
<NEJM> Dalcetrapib(ロッシュ)はCETPを阻害してHDLコレステロールを増加させるが、心血管リスクは減少させない。http://t.co/q6S64l0W <Lancet>HDLに直接の心血管保護作用がないこと示唆 http://t.co/O4WKjEi3
Plasma HDL #cholesterol and risk of myocardial infarction: a mendelian randomisation study. http://t.co/4AgH47hl
LANCET>The HDL paradox>>Mendelian randomization study challenge that HDL reduces myocardial infarction http://t.co/mrbCyAiz
Plasma #HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. http://t.co/4enjcmD7
Cholesterol becomes ever more complicated: Now, you also have to know where that "good" HDL comes from, before... http://t.co/h7MpOUay
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. http://t.co/GDXT7fuJ
MS2 - HDL MUCH more complicated than LDL - study raised ? re: genetically elevated HDL and IF it really decreases risk http://t.co/OTdVy6zZ
Data challenge the concept that raising of plasma HDL cholesterol will reduce risk of myocardial infarction http://t.co/KeMwyF3o
Data challenge the concept that raising of plasma HDL cholesterol will reduce risk of myocardial infarction http://t.co/KeMwyF3o
test http://t.co/5RZKIBe8
test http://t.co/5RZKIBe8
test http://t.co/5RZKIBe8
test http://t.co/5RZKIBe8
test http://t.co/5RZKIBe8
Data challenge the concept that raising of plasma HDL cholesterol will reduce risk of myocardial infarction http://t.co/xOf5fRD5
HDL必ずしも善玉ならず http://t.co/elCGG1WX
Data challenge the concept that raising of plasma HDL cholesterol will reduce risk of myocardial infarction http://t.co/xOf5fRD5
Data challenge the concept that raising of plasma HDL cholesterol will reduce risk of myocardial infarction http://t.co/xOf5fRD5
High HDL cholesterol (good cholesterol ) is not linked with any reduction in heart attack. http://t.co/0Y3rJUXy via @sharethis
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. http://t.co/KaquWpGG
Two studies on HDL-C-raising strategies have been stopped mid-stream and now an international group finds that... http://t.co/KCls5sHs
Find out more: questions relation between HDL cholesterol and myocardial infarction http://t.co/L2v5mAuw
Find out more: questions relation between HDL cholesterol and myocardial infarction http://t.co/L2v5mAuw
@Marianela_SCup http://t.co/IvAcIVvF Aquí el estudio de las HDL
従来の知見覆る? HDL-C高値と心筋梗塞リスク低下に関連なし 欧米の大規模遺伝疫学研究 http://t.co/DjKwaKq0
Raising HDL does not always lower heart attack risk. http://t.co/ddTjIPHS