@ifixhearts lol evidence: Provides a link to his $10 e book. Pub med is free people! Mendelian randomization is strong evidence that HDL isn’t important in the context of high LDL and high TG. https://t.co/q5nT4pf6Ja
@Rico_apoach Boaf, en association causale ça parle de "blood lipid profile". Or le HDL n'est pas vraiment cardioprotecteur, contrairement à ce qu'on a longtemps pensé. https://t.co/ooG0pDt64Q https://t.co/WVFlwkopR9
RT @ZahcM: "There has been much debate on its role, as elevated HDL-C levels do not appear to protect against CVD in MR analysis. However,…
RT @ZahcM: "There has been much debate on its role, as elevated HDL-C levels do not appear to protect against CVD in MR analysis. However,…
"There has been much debate on its role, as elevated HDL-C levels do not appear to protect against CVD in MR analysis. However, more recently, an MR study indicated a protective effect of HDL-C on CVD risk, perhaps due to a larger sample size . . ." https
@EpiEllie @tudballstats @PWGTennant the two papers I tweeted have detailed discussions of the assumptions https://t.co/XBgmYO67Py
@EpiEllie @tudballstats @PWGTennant 3/n an influential couple of the HDL MR papers referenced https://t.co/FUpKrLzL8J and https://t.co/w4KVMRTJxL
RT @skathire: HDL and LDL are two areas where MR worked quite well. LDL: causal for atherosclerosis HDL: non-causal risk marker See her…
RT @skathire: HDL and LDL are two areas where MR worked quite well. LDL: causal for atherosclerosis HDL: non-causal risk marker See her…
HDL and LDL are two areas where MR worked quite well. LDL: causal for atherosclerosis HDL: non-causal risk marker See here: https://t.co/aswUgD5nCp
Some genetic mechanisms that raise plasma HDL cholesterol do not seem to lower risk of myocardial infarction. These data challenge the concept that raising of plasma HDL cholesterol will uniformly translate into reductions in risk of myocardial infarction.
@KetoCarnivore @Jacobiome @Libertas2008 @raphaels7 @SBakerMD Yeah so much wrong with that post. It doesn’t even address the paper I posted. Cites a bunch of papers from the 90s. HDL is no longer considered protective. https://t.co/fa3lXhsw3L https://t.co/o
@Springandashura Questions started > two decades or longer if you look at genetic low HDLc disorders & then drug studies (niacin, fibrate & estrogen, CETPi, probucol). Or sSee https://t.co/ATWDamn7nv and https://t.co/PLVCXJLaVP and https://t.co/
Pour les études génétiques : https://t.co/z4IZVGqpXE ⬇️ https://t.co/xwj7d8uxz1
@CarnalDancer @pjungar @MarkBski Also this wasn't an artificial change👇 https://t.co/erg6wXaFCq
@CarnalDancer @pjungar @MarkBski And mandellian randomization studies don't show an effect either (they are the best type of evidence that exists short of of randomized controlled trials): https://t.co/7Qr4tShdcZ
@itzzCogie @FibbinTiggins @ddofinternet Sure you can explain what is wrong with the MR Data, wich supercedes obervational research wich is confoundet trough mulible factores. Also you sure can explain with hdl increasing drugs dont work https://t.co/Qahw6
@MariaJonsson1 Här är en studie men det största beviset är alla miljarder som läkemedelsföretag har plöjt ner i läkemedel som höjer HDL utan att ge några kliniskt påvisbara nyttor. https://t.co/IyWoewLCoS
@Dereklowe HDL is a great example of the difference btw observational data and causality. Mendelian randomization could have saved everyone billions if it had happened before https://t.co/jo5HXCLcWu
Dat terwijl Mendelian randomization dit met een fractie van de kosten ook aan had getoond. https://t.co/MBm5ckd5zr
RT @Drlipid: @NutritionMadeS3 @HealthyChefJim Low HDL-C is one of many indictors of ASCVD risk but never a goal of Rx. There is zero causal…
@NutritionMadeS3 @HealthyChefJim Low HDL-C is one of many indictors of ASCVD risk but never a goal of Rx. There is zero causality evidence for HDL https://t.co/7jZ0lE7JOB https://t.co/IBCtblGLA5
@Agent_Psmith Genetically high LDL doesn’t seem to offer protection against MI’s. If you have any data w/ similar power, I’d love to see it! https://t.co/NsRWrKz7GK
RT @skathire: @Luke0connor When new method applied to risk factor exposures & MI outcome, following stand out with causal support from huma…
RT @NutritionMadeS3: commonly ignored current scientific understanding: HDL changes are likely not causal meaning: raising your HDL likely…
RT @NutritionMadeS3: @AmandaZZ100 @xristianplante @EricTopol @undarkmag @Medium TC/HDL more predictive than LDL https://t.co/ywFM0vkTa6 h…
RT @NutritionMadeS3: @rochmciv @futu00 @robbie_moreland @POhukainen the direct tests do not support a causal protective role of HDL availa…
RT @NutritionMadeS3: @rochmciv @futu00 @robbie_moreland @POhukainen the direct tests do not support a causal protective role of HDL availa…
@Jevan @DBelardoMD @ancelkeyslegacy Well to be fair it's more than just the fact those interventions have proved ineffective. Mendelian studies show genetic mutations that result in high HDL do not seem to offer protection either: https://t.co/6G6RrG4n2s
HDL boosting https://t.co/BAhskUP6FI LDL lowering https://t.co/J7pnm2PbNl Genetically low LDL https://t.co/GDoQT5n6oh Genetically high HDL https://t.co/BAhskUP6FI
RT @NutritionMadeS3: @AmandaZZ100 @xristianplante @EricTopol @undarkmag @Medium TC/HDL more predictive than LDL https://t.co/ywFM0vkTa6 h…
RT @NutritionMadeS3: commonly ignored current scientific understanding: HDL changes are likely not causal meaning: raising your HDL likely…
@Herd851 Genetically high HDL is not uniformly associated with reduced CVD risk https://t.co/LfXK0mEUXZ Meanwhile, MR studies consistently demonstrate lower CVD risk with genetically lower LDL https://t.co/GDoQT5n6oh So it's probably not wise to focus
RT @mendel_random: There were some suggestions about the surprising conclusions regarding circulating HDL cholesterol before 2012 👇 https:/…
RT @mendel_random: There were some suggestions about the surprising conclusions regarding circulating HDL cholesterol before 2012 👇 https:/…
RT @AlexTISYoung: I remember seeing @skathire give a talk about this and other applications of genetics in medicine when I was PhD student…
RT @mendel_random: There were some suggestions about the surprising conclusions regarding circulating HDL cholesterol before 2012 👇 https:/…
RT @mendel_random: There were some suggestions about the surprising conclusions regarding circulating HDL cholesterol before 2012 👇 https:/…
There were some suggestions about the surprising conclusions regarding circulating HDL cholesterol before 2012 👇 https://t.co/aZzPr8oYmC
One of the exercise I assign to medical students is to replicate these results in MRbase and present the findings. https://t.co/9DafSqCvNu
RT @doctorveera: The classic MR paper 😍. You can't talk about MR without referring to this paper.
The classic MR paper 😍. You can't talk about MR without referring to this paper.
I remember seeing @skathire give a talk about this and other applications of genetics in medicine when I was PhD student at Oxford. That genetics can be a powerful tool to tease apart causation and confounding in humans has stuck with me ever since.
RT @skathire: what prediction have you made that has (surprisingly) held up over time? For me, 👇 in 2012 with @bvoight28, Gina Peloso, an…
RT @skathire: what prediction have you made that has (surprisingly) held up over time? For me, 👇 in 2012 with @bvoight28, Gina Peloso, an…
RT @redGDPS: El código genético …. rs1333458 Clinical utilities of this knowledge ✅ Mendelian randomization: causal biomarkers. HDL-c (To…
#Kardiyoloji iyi kolesterol (HDL) un yuksek olmasi iyidir sizi korur sacmaliginin gercek olmadigi ispat edilince. hangi ongorunuzu zaman hakli cikardi soylemiyle paylasan hoca 2012 yilinda bunu soylemis. cunku #genetik diye bir sey var.
RT @redGDPS: El código genético …. rs1333458 Clinical utilities of this knowledge ✅ Mendelian randomization: causal biomarkers. HDL-c (To…
El código genético …. rs1333458 Clinical utilities of this knowledge ✅ Mendelian randomization: causal biomarkers. HDL-c (Torcetrapib) Voight B, et al. Lancet 2012;380:572-80. https://t.co/B6o1nJTmcA Barter PJ et al. NEJM 2007;357:2109-22 https://t.
RT @skathire: what prediction have you made that has (surprisingly) held up over time? For me, 👇 in 2012 with @bvoight28, Gina Peloso, an…
RT @skathire: what prediction have you made that has (surprisingly) held up over time? For me, 👇 in 2012 with @bvoight28, Gina Peloso, an…
what prediction have you made that has (surprisingly) held up over time? For me, 👇 in 2012 with @bvoight28, Gina Peloso, and D. Altshuler https://t.co/aswUgD5nCp https://t.co/lh0esNrC1M
RT @doctorveera: Today I had weekly call with bachelor students where we discussed this classic MR study of the association of HDL choleste…
Today I had weekly call with bachelor students where we discussed this classic MR study of the association of HDL cholesterol with MI. Though I've read this before, rereading it made me realise how beautiful and perfect the findings in this study are! http
RT @skathire: From 2012, with @bvoight28 https://t.co/8Jzvny9mga https://t.co/R6tIyXt93B
RT @skathire: From 2012, with @bvoight28 https://t.co/8Jzvny9mga https://t.co/R6tIyXt93B
RT @skathire: From 2012, with @bvoight28 https://t.co/8Jzvny9mga https://t.co/R6tIyXt93B
RT @skathire: From 2012, with @bvoight28 https://t.co/8Jzvny9mga https://t.co/R6tIyXt93B
RT @skathire: From 2012, with @bvoight28 https://t.co/8Jzvny9mga https://t.co/R6tIyXt93B
From 2012, with @bvoight28 https://t.co/8Jzvny9mga https://t.co/R6tIyXt93B
@DaveKeto @FatEmperor @NutritionDanny @mrc314 @LDLskeptic2 @newyorker1213 Great, looking fwd to it. Here's a MR study that I see often referenced for shooting down the positives of higher HDL levels. Not sure if you've read: https://t.co/96lrc4vWcq
HDL levels are strongly associated with reduced risk of cardiovascular disease, but Mendelian randomization (https://t.co/IkO1jcZSlS) and clinical trials (https://t.co/Y3skNNBWI1) suggest that this association is not causal. 2/
@iyas_daghlas @manuelrivascruz Using LDL as the exposure trait to deduce impact on CAD doesn't feel so different from Sek's classic 2012 Lancet paper: https://t.co/schL9owcoc
@POhukainen interesting. other MR studies don't find a benefit for HDL in heart disease. this one sees a benefit for longevity... presumably through other mechanisms? https://t.co/tJRE4IxtUZ
@rochmciv @futu00 @robbie_moreland @POhukainen the direct tests do not support a causal protective role of HDL available data indicates you CANNOT make up for high LDL with high HDL (by all means link data proving the opposite, I haven't seen it) https:/
@AmandaZZ100 @xristianplante @EricTopol @undarkmag @Medium TC/HDL more predictive than LDL https://t.co/ywFM0vkTa6 however, HDL not causal unlike LDL https://t.co/tJRE4IxtUZ https://t.co/RxtS0Ravlj bottomline: expert opinion=raising HDL not helpful.
commonly ignored current scientific understanding: HDL changes are likely not causal meaning: raising your HDL likely does not affect your risk of CVD i.e. high HDL does not protect against high LDL https://t.co/tJRE4IxtUZ
@RChrisCC @upyrbike @lowcarbGP @bschermd @DrAseemMalhotra @BrownAdey @ChristianAssad @ProfTimNoakes @DrScottMurray @FatEmperor @ESodicoffMD @Dr__Guess @tom_watson @PharmacistCath @KetoAnaesMD @FructoseNo Hi! Do you have references for those statements? Are
@Sadrien_GW2 Genetic: https://t.co/l570QUttED HDL just go down for diabetics, low exercise etc, so it catches those cases in epi data. But it is just a marker, not causative by itself. That is why research now focus more on improving HDL cholesterol flux
@starofthesea171 @bigfatsurprise @bschermd Counting on high HDL-C induced by eating SFA wouldn't make sense. In contrast to LDL-C, it hasn't been shown to be a causative agent through randomized trials or genetics. HDL-C is only good in epi data due to oth
@AmandaZZ100 @KoushikReddyMD And as already stated, banking on HDL being protective is dangerous - there is purely epi data to support it, a correlation that has to do with good IS, excercise, etc. But HDL by itself is NOT protective, as shown in this st
@DrFrankLipman @DrAseemMalhotra Do you know that HDL has been disproven as having a causal effect on coronary artery disease? See: https://t.co/eS7iUzvJjV AND https://t.co/JFLMM7ahqn so raising HDL is not useful..
@Luke0connor When new method applied to risk factor exposures & MI outcome, following stand out with causal support from human genetics: 1. LDL 2. TRL 3. BMI 4. but not HDL Quite consistent with our earlier work on HDL here https://t.co/8Jzvny9mga
@DrEliDavid HDL has not been shown to be protective against CVD with medications or using Mendelian randomization techniques. https://t.co/aJ5uB1Zoss https://t.co/1CmJi0WvOo https://t.co/qkYJiwnXEs
@AthleX2 @ninehigh99 @bigfatsurprise Agreed with ninehigh99, parasites may be needed. HDL levels is not something you should count on! The correlation between low HDL and CVD is driven by insulin resistance causing low HDL - just raising your HDL by eating
RT @antonioregalado: 10/ More seriously, billions $$ at stake when it comes to figuring out what causes heart disease, and therefore what d…
10/ More seriously, billions $$ at stake when it comes to figuring out what causes heart disease, and therefore what drugs to develop. Like this whopper from 2012 in which @skathire et al found "good" HDL cholesterol doesn't protect against heart disease.
Following up on the HDL MR study that may be applicable to suPAR https://t.co/2ck0pp9e2v @JochenReiser https://t.co/oQ4r6HmQey https://t.co/znnnLNEEdH
@keithsigelmd I think that a single coding variant approach in a gene where the biology is well understood (e.g. https://t.co/8CO2kmPl2T) is superior - unfortunately no such variant (yet) exists for WHRadjBMI
RT @mendel_random: TImeline and geography of Mendelian randomization (1) the concept 1951 (Bayfordbury) to 1986 (Hawaii), via Bethesda, Mad…
RT @mendel_random: TImeline and geography of Mendelian randomization (1) the concept 1951 (Bayfordbury) to 1986 (Hawaii), via Bethesda, Mad…
RT @mendel_random: TImeline and geography of Mendelian randomization (1) the concept 1951 (Bayfordbury) to 1986 (Hawaii), via Bethesda, Mad…
TImeline and geography of Mendelian randomization (1) the concept 1951 (Bayfordbury) to 1986 (Hawaii), via Bethesda, Madison and Rochester; (2) the name, 1991 (Oxford) https://t.co/YTB2Ks9rOc https://t.co/JywmLTS1qn
RT @skathire: @martijnkatan @mendel_random Deeply indebted to your insight to use gene variants as instruments for causal inference. See…
@martijnkatan @mendel_random Deeply indebted to your insight to use gene variants as instruments for causal inference. See 👇 https://t.co/DDD4SziFWV P.S. Lots of key insights seem to arise in beaches: Mullis & PCR, Katan & MR 😊 https://t.co/c
Inte heller har det blivit något stöd från studier baserade på mendelsk randomisering. https://t.co/gzLJu7V9JI
RT @skathire: leverage discovered DNA variants for causal inference 3/ https://t.co/BBMUGIVR59 https://t.co/6cfyxOMnD5 https://t.co/jYq5htL…
RT @skathire: leverage discovered DNA variants for causal inference 3/ https://t.co/BBMUGIVR59 https://t.co/6cfyxOMnD5 https://t.co/jYq5htL…
leverage discovered DNA variants for causal inference 3/ https://t.co/BBMUGIVR59 https://t.co/6cfyxOMnD5 https://t.co/jYq5htLz2d
RT @drjohnm: See also this on #Anacetrapib > Thanks all you experts. https://t.co/D7PheBbzJO
RT @skathire: in light CETP news, 2012 pub from lab which found: raising HDL - not helpful lowering LDL - (almost) always good https://t.co…
RT @skathire: in light CETP news, 2012 pub from lab which found: raising HDL - not helpful lowering LDL - (almost) always good https://t.co…
RT @drjohnm: See also this on #Anacetrapib > Thanks all you experts. https://t.co/D7PheBbzJO
RT @drjohnm: See also this on #Anacetrapib > Thanks all you experts. https://t.co/D7PheBbzJO