@NeurocritCareJ 3/ Evidence from RAMPART (https://t.co/MP6ZnG84SK) tells us we should give benzos early for anyone with >5 mins or with persistent seizure when 🚑 arrives, so if you picked give benzos, you were correct! https://t.co/0s4hgC4TIy
🧠Neuro/PADIS💤 Region Second Round Voting #1 NINDS v. #8 RAMPART NINDS: https://t.co/tmnPi2BePO RAMPART: https://t.co/Ufl3OwOZq3 https://t.co/Kl80Up3QEU
🧠Neuro/PADIS💤 Region #8 RAMPART v #9 VA Co-Op RAMPART: https://t.co/Ufl3OwOZq3 VA Co-Op: https://t.co/eGH8QKZG72 https://t.co/g9AmItSqQQ
@TBevansNOLS @ShitbitA https://t.co/3xcIVYBjwb We need to shift to thinking about seizure termination more along the lines of the way we think about adrenaline in anaphylaxis Those 2 minutes matter Plus You’re two minutes is someone else’s 6 minutes
Intramuscular versus intravenous therapy for prehospital status epilepticus: https://t.co/xj9FkhQ3vK
#TrialOfTheDay for May 11th is the RAMPART trial Do we have a preferred route of administration for BZDs in pre-hospital status epilepticus? Open Access Article link: https://t.co/Ufl3OwOZq3 #pharmICU #TwitteRX #neurotwitter #seizure #statusepilepticus
https://t.co/06cZ8hEeAn "Intramuscular versus intravenous therapy for prehospital status epilepticus" PMID: 22335736 PMCID: PMC3307101 https://t.co/q5PMVWMKhg 二重盲検、無作為化、非劣性試験。BZP投与で6-7割のSEの消失が認められる。
RT @LeonardoSotoMu: Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus | NEJM https://t.co/Uzm1Q9Ufmj
Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus | NEJM https://t.co/Uzm1Q9Ufmj
RT @SMHNeurology: SMH Rounds (6-4): Pearl 3: In a patient with status epilepticus and no IV access, administer Midazolam 10 mg IM (5mg if <…
RT @JoshuaStilley: In seizures, time to benzodiazepine effect much faster if given IM than IV. This is thanks to the RAMPART trial. Now to…
RT @JoshuaStilley: In seizures, time to benzodiazepine effect much faster if given IM than IV. This is thanks to the RAMPART trial. Now to…
@DrJeffJarvis @rpcrowe @srjattorney @BoNaderPrater @md59 @HandtevyMD If only there were a prehospital RCT that shows safe, effective dosing…. https://t.co/FsJBkEmEmP
In seizures, time to benzodiazepine effect much faster if given IM than IV. This is thanks to the RAMPART trial. Now to explain to my residents what RAMPART means. #EMSCaseReview #EMS #Emergency #emergencymedicine https://t.co/G7N5ijVqci
@embasic @bougiemedic Not all benzos d same, IM midazolam as good as IV loraz based on some studies; IV diaz if with IV access but duration is long maybe good or bad depends on your expected outcome and next intervention or plan of action. https://t.co/7YB
RT @EMPoisonPharmD: "Give BZD and if it doesn't work, intubate" How long after BZD is given until seizure breaks?! RAMPART trial (https://t…
RT @EMPoisonPharmD: "Give BZD and if it doesn't work, intubate" How long after BZD is given until seizure breaks?! RAMPART trial (https://t…
RT @EMPoisonPharmD: "Give BZD and if it doesn't work, intubate" How long after BZD is given until seizure breaks?! RAMPART trial (https://t…
RT @EMPoisonPharmD: "Give BZD and if it doesn't work, intubate" How long after BZD is given until seizure breaks?! RAMPART trial (https://t…
"Give BZD and if it doesn't work, intubate" How long after BZD is given until seizure breaks?! RAMPART trial (https://t.co/K3XlznsFDd)  4mg IV lorazepam: Median⏰~ 90 sec (assuming evidence based dose) 50% need >90s, waiting 90s (if airway ok) may pre
けいれん重積において、病院到着前の介入を検討したRCT けいれん重積状態に対しては、ミダゾラムの筋肉内投与は、入院前の発作停止のためのロラゼパムの静脈内投与と少なくとも同等の安全性と有効性を有する。 https://t.co/Sa8nzSSt4D
In an interesting study that changed the pre-hospital treatment of status epilepticus, IM Midazolam was found to be non-inferior and as safe as IV Lorazepam, with the added benefit of not needing refrigerated. #CincyAI https://t.co/Ww3dwoFYRg
@RozehnalMd @scott_mintzer @emily_fri @LvelezEM And to be clear rct data shows that multiple options are good. https://t.co/pTKgbxV60Y RAMPART showed IM midazolam and IV Ativan showed noninferiority for IM midazolam vs lorazepam. I think you're good eith
@emily_fri I don't have the answer, feel like something is missing here. If lorazepam is so ineffective for etoh withdrawal, why does it do just dandy for prehospital status epilepticus? Dosing inconsistent? Pathophys diff? Not stored properly (fridge)? ht
RT @SMHNeurology: SMH Rounds (6-4): Pearl 3: In a patient with status epilepticus and no IV access, administer Midazolam 10 mg IM (5mg if <…
SMH Rounds (6-4): Pearl 3: In a patient with status epilepticus and no IV access, administer Midazolam 10 mg IM (5mg if < 40 kg) STAT. A landmark trial - RAMPART - in @NEJM from 2012 addressed the question of IM vs. IM treatment for prehospital status.
Hospital admission lower in IM midazolam (P= 0.01) #UMKCRCT
Non-inferiority/superiority trial; placebo controlled was not option, as would be unethical; #UMKCRCT; Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus | NEJM https://t.co/qPC3xcFW49
Those aborted w SE, time to treat was significantly shorter in IM vs IV ( 1.2 vs 4.8 min) and we know time is the determinant for prognosis following SE #UMKCRCT
non-inferiority or superiority trial showing IM midazolam as effective as iv lorazepam in prehospital SE; #UMKCRCT; Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus | NEJM https://t.co/v9CQZEreCp
@DoctorGoodleg @mitchpage3 @emupdates 10mg IM was based on the RAMPART study. It works great and in my experience (with heavy QI/QA), no greater adverse effects than the traditional 2mg of Ativan IV. https://t.co/2g5p2v76ux https://t.co/P8TkQmpcwO http
@ZoiNetou @dens_r_d @Marzipanmonster Ich möchte widersprechen :) Zu Midazolam und Anfällen: https://t.co/qhMs6V4Mdl
@frollein_doktor I disagree :) https://t.co/qhMs6V4Mdl Midazolam ist sicher und effektiv für Anfälle, muss aber nicht gekühlt werden, damit insbes. präklinisch keine schlechte Wahl. Lorazepam ist verzichtbar.
IM midazolam is just as good as IV lorazepam in patients with status epilepticus. Dont delay benzo administration if you can't get an IV. https://t.co/hkvLoMhe4V #CincyAI
RT @MKleinMD: Seizing patient without IV access? IM midazolam works! #OnShiftTeaching with @NorthwesternEM PGY4 Jesus Trevino https://t.…
RT @MKleinMD: Seizing patient without IV access? IM midazolam works! #OnShiftTeaching with @NorthwesternEM PGY4 Jesus Trevino https://t.…
RT @MKleinMD: Seizing patient without IV access? IM midazolam works! #OnShiftTeaching with @NorthwesternEM PGY4 Jesus Trevino https://t.…
RT @MKleinMD: Seizing patient without IV access? IM midazolam works! #OnShiftTeaching with @NorthwesternEM PGY4 Jesus Trevino https://t.…
RT @MKleinMD: Seizing patient without IV access? IM midazolam works! #OnShiftTeaching with @NorthwesternEM PGY4 Jesus Trevino https://t.…
RT @MKleinMD: Seizing patient without IV access? IM midazolam works! #OnShiftTeaching with @NorthwesternEM PGY4 Jesus Trevino https://t.…
RT @MKleinMD: Seizing patient without IV access? IM midazolam works! #OnShiftTeaching with @NorthwesternEM PGY4 Jesus Trevino https://t.…
RT @MKleinMD: Seizing patient without IV access? IM midazolam works! #OnShiftTeaching with @NorthwesternEM PGY4 Jesus Trevino https://t.…
RT @MKleinMD: Seizing patient without IV access? IM midazolam works! #OnShiftTeaching with @NorthwesternEM PGY4 Jesus Trevino https://t.…
RT @MKleinMD: Seizing patient without IV access? IM midazolam works! #OnShiftTeaching with @NorthwesternEM PGY4 Jesus Trevino https://t.…
RT @MKleinMD: Seizing patient without IV access? IM midazolam works! #OnShiftTeaching with @NorthwesternEM PGY4 Jesus Trevino https://t.…
Seizing patient without IV access? IM midazolam works! #OnShiftTeaching with @NorthwesternEM PGY4 Jesus Trevino https://t.co/RaBpvQQK5v https://t.co/SGRfODhlix
No IV access? No worries. Consider IM benzos. #critPRN #SE https://t.co/TAZKlpTl7N
RT @HuskERdr: RAMPART study prehosp IM midazolam~iv loraz in status epilepticus-effective https://t.co/PoBjIwofAu @NebraskaEM @UNMCEMSDOC #…
RT @HuskERdr: RAMPART study prehosp IM midazolam~iv loraz in status epilepticus-effective https://t.co/PoBjIwofAu @NebraskaEM @UNMCEMSDOC #…
RT @EMSimWars: #simwars "Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus" https://t.co/o6PmZFdR5A
#simwars "Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus" https://t.co/o6PmZFdR5A
Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus. http://t.co/cvrWlKEE6d
.@IriaMiguens Muy bueno Iria!! Ojo que el uso de autoinyector IM compensó <t inicio acción IV http://t.co/bH2Fw9Gqqc http://t.co/AigQ7Rvcs2
.@IriaMiguens Muy bueno Iria!! Ojo que el uso de autoinyector IM compensó <t inicio acción IV http://t.co/bH2Fw9Gqqc http://t.co/AigQ7Rvcs2
IM Versed is... "at least as safe and effective as IV Ativan" and saves 3 mins. — NEJM http://t.co/Fn2JHeFrSM #FOAMems #paramedic #FOAMed
IM Versed is... "at least as safe and effective as IV Ativan" and saves 3 mins. — NEJM http://t.co/Fn2JHeFrSM #FOAMems #paramedic #FOAMed
Your arrive to find your patient in active sz (confirmed epilepticus). Whats your next move? IV or IM? — NEJM http://t.co/UKgKWWosFd
Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus — NEJM http://t.co/o0OIfpSZC9
Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus — NEJM http://t.co/o0OIfpSZC9
さっきのミダゾラムの。海外の救急隊すげーなあ。日本じゃ搬送先探してる間重責だもんな Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus http://t.co/LmHKqV7Y8a
さっきのミダゾラムの。海外の救急隊すげーなあ。日本じゃ搬送先探してる間重責だもんな Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus http://t.co/LmHKqV7Y8a
Next time you have a STATEP, don’t waste time with an IV: http://t.co/K20pzjKG2e #nycems
Evidence for non-inferiority of IM midaz vs IV loraz in pre-hospital status - http://t.co/RwrL4oXoUd - #ARV reaching
Evidence for non-inferiority of IM midaz vs IV loraz in pre-hospital status - http://t.co/RwrL4oXoUd - #ARV reaching
Evidence for non-inferiority of IM midaz vs IV loraz in pre-hospital status - http://t.co/RwrL4oXoUd - #ARV reaching
#EBMEMS EMS that can't use Ativan d/t quick expiration, consider IM Versed instead of Valium. http://t.co/4zSYvPFMxq #FOAMed #EMS
エピに対する病院前の治療。 http://t.co/Z4PaNVdwyd
@epileptologo Supporting research? Effective seizure termination with adequate benzo dosing improves outcomes http://t.co/tou44H8Dve
@flobach Recent RAMPART study showed IM midazolam superior to IV lorazepam for seizure termination http://t.co/8bOmlDQMPF
RT @damounnassehi: For #statusepilepticus, #intramuscular #midazolam is as effective as i.v. #lorazepam for prehospital seizure cessation http://t.co/O4bU6vcK
@AAEMRSA Midazolam IM/IV/IN is also an effective first line therapy, and may be superior in some circumstances http://t.co/A5wKYfSM
Also one of few emergency drugs in #hpm (also used subcutaneously) RT @fabiodeiaco Midazolam as a true emergency drug http://t.co/SkU2K55G
Also one of few emergency drugs in #hpm (also used subcutaneously) RT @fabiodeiaco Midazolam as a true emergency drug http://t.co/SkU2K55G
Also one of few emergency drugs in #hpm (also used subcutaneously) RT @fabiodeiaco Midazolam as a true emergency drug http://t.co/SkU2K55G
Midazolam as a true emergency drug: another evidence http://t.co/oaE2xwbQ
@Atefrashed MDZ dosing IM 10mg 40kg+ 5mg 13-39kg http://t.co/V6kjrKAf McMullan Peds IN 0.2 mg/kg http://t.co/LyyD429k
@Atefrashed With no IV, suggest midazolam IM or IN http://t.co/V6kjrKAf http://t.co/LyyD429k
@Docvpb @socalexmd @M_Lin MDZ e.g. RAMPART IM 10mg 40kg+ 5mg 13-39kg http://t.co/eWPZteYY McMullan Peds IN 0.2 mg/kg http://t.co/UiWwqUtx
Terapia IM x IV para estado de mal epiléptico pré-hospitalar (N Engl J Med) http://t.co/Hsuy5KYR
http://t.co/1v8CueYB should take you to the paper...
院外痙攣重積発作での非劣性RCT(NETT).救急部到着時に治療せずに痙攣が停止していたのはmidazolam筋注が73.4%,lorazepam静注が63.4%.挿管,痙攣再発は同じ.N Engl J Med 2012;366:591.http://t.co/4TKXnt76
Prehospital IM Lorazepam use in children: http://t.co/HHVhjYY6
RT @escorcia_jorge: @neuronan NEJM | Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus http://t.co/19a4Yv1a
@neuronan NEJM | Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus http://t.co/19a4Yv1a
(NEJM) Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus http://t.co/FyTfJrbD Igual de efectivos
On the way to the hospital, IM injection of #midazolam may be better for treating ongoing seizures than IV #lorazepam. http://t.co/3oSkJBJI
IM midazolam vs IV lorazepam for prehospital status epilepticus http://t.co/ChSrs78W
In status epilepticus, intramuscular midazolam is at least as safe & effective as IV lorazepam http://t.co/0sjnRIOF
Wonderful advances in treating Status Epilepticus from a NIH/NINDS national trial. http://t.co/HKPXjvhR
For #statusepilepticus, #intramuscular #midazolam is as effective as i.v. #lorazepam for prehospital seizure cessation http://t.co/O4bU6vcK
RT @JNNP_BMJ: Intramuscular midazolam is as effective as intravenous medication in stopping status epilepticus. http://t.co/VqqSlOi9
RT @JNNP_BMJ: Intramuscular midazolam is as effective as intravenous medication in stopping status epilepticus. http://t.co/VqqSlOi9
RT @JNNP_BMJ: Intramuscular midazolam is as effective as intravenous medication in stopping status epilepticus. http://t.co/VqqSlOi9
RT @JNNP_BMJ: Intramuscular midazolam is as effective as intravenous medication in stopping status epilepticus. http://t.co/VqqSlOi9
Intramuscular midazolam is as effective as intravenous medication in stopping status epilepticus. http://t.co/VqqSlOi9
Intramuscular versus intravenous therapy for prehospital status epilepticus. http://t.co/tt8jpkiy
RT @AusParamedics: Intramuscular vs intravenous therapy for prehospital status epilepticus http://t.co/z8nZBsrf. See more new research: http://t.co/OeG5aLnv
This would be a great study in our patients. http://t.co/esVrCJ5U
“@NEJM: Intramuscular midazolam at least as safe and effective as IV lorazepam for prehospital status epilepticus. http://t.co/2DTlZBsV