Innovative genetics work from our own @CrisRiellaMD, leading the charge in our division of integrating a genetics approach to clinical care as well!
Excited to share our work 👊🧬. A collaboration between Friedman, Pollak and @kidneyomicsamps labs. Thank you @nkf for the Young Investigator Research Grant support. @BIDMC_Medicine @BID_NephFellows @guilhermeribas @m_t_mcnulty #APOL1 #kidney #NephTwitter ht
ADAR regulates APOL1 via A-to-I RNA editing by inhibition of MDA5 activation in a paradoxical biological circuit | Proceedings of the National Academy of Sciences https://t.co/uH4JYdXVcz
ADAR regulates APOL1 via A-to-I RNA editing by inhibition of MDA5 activation in a paradoxical biological circuit | @PNASNews https://t.co/SAD9alvhVI @SonOfBarth Dave Friedman @kidneyomicsamps Consistent with the role of cytosolic nucleotide sensors? STING
Happy to contribute to this paper. ADAR A-I editing of APOL1 mRNA reduces it's expression in podocytes & mouse glomeruli after interferon challenge. Enjoyed helping to illuminate some aspects of APOL1's regulation that may represent one of many potenti
@m_t_mcnulty & @kidneyomicsamps were psyched to contribute to this paper on #APOL1 regulation via RNA-editing led by @CrisRiellaMD David Friedman, & Martin Pollak. #kidneyomics https://t.co/ncZ9mZQ3Ll @BostonChildrens @broadinstitute @BIDMChealth
ADAR regulates APOL1 via A-to-I RNA editing by inhibition of MDA5 activation in a paradoxical biological circuit https://t.co/SjGyGfRCPj