RT @StephanHacker2: Paper by the group of Shaomeng Wang @MichiganChem in @JMedChem. Optimization of covalent ligands for menin that inhibit…
RT @StephanHacker2: Paper by the group of Shaomeng Wang @MichiganChem in @JMedChem. Optimization of covalent ligands for menin that inhibit…
Paper by the group of Shaomeng Wang @MichiganChem in @JMedChem. Optimization of covalent ligands for menin that inhibit the menin-MLL protein-protein interaction. Might be a record setting number of four azetidines in a highly active compound (compound 14)
Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong In Vivo Antitumor Activity https://t.co/XFJyec4cS0 #nor論文 共有結合型メニン阻害剤。MLLとのPPIを阻害。中身見てないけど、どんな設計だろう。合成も単純ではなさそうだな
Exciting work by Shaomeng Wang @MichiganChem published in @JMedChem: discovery of a covalent disruptor of the Menin–MLL protein-protein interaction. A fascinating structure, complete with a 3-(sulfonyl)-azetidine-1-acrylamide warhead! #covalentinhibitors h
RT @yuukiwomanabu: ミシガン大、Shaomeng Wang先生。vivoで抗腫瘍活性を示す化合物の合成から薬理活性についてまで。 #学ぶの論文紹介 Discovery of M-808 as a Highly Potent, Covalent, Small-M…
ミシガン大、Shaomeng Wang先生。vivoで抗腫瘍活性を示す化合物の合成から薬理活性についてまで。 #学ぶの論文紹介 Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong In Vivo Antitumor Activity https://t.co/UVd8X3n0oX