@ifinatamabDXd yeah its some variant of this (same team/authors) https://t.co/6HLbs4dS0Q
RRIDs were included in the Cancer Cell paper "A Potent and Selective Small-Molecule Degrader of…" (https://t.co/VmT21tVDvO). Thank you for making your #methodsmatter. #ReproducibleResearch
The authors of "A Potent and Selective Small-Molecule Degrader of…" (https://t.co/VmT21tVDvO) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #STMpublishing #methodsmatter
RT @BioBill2: A well written explanation on the utility of a stat3 degrader overcoming the limitations of a sm inhibitor. https://t.co/DNFF…
RT @BioBill2: A well written explanation on the utility of a stat3 degrader overcoming the limitations of a sm inhibitor. https://t.co/DNFF…
RT @BioBill2: A well written explanation on the utility of a stat3 degrader overcoming the limitations of a sm inhibitor. https://t.co/DNFF…
A well written explanation on the utility of a stat3 degrader overcoming the limitations of a sm inhibitor. https://t.co/DNFFzOnvfu $kymr
https://t.co/tv1o7z9BWF A nice example of phosphonate drug that is so potent, that despite a free phosphonate, which would confer poor permeability, the potency is good (<nM against its target), that low uM doses are sufficient to achieve activity in c
RT @MichaelADyerLab: A small molecule targeting STAT3 was shown to experimentally treat AML in vivo. This new molecule could be a useful to…
RT @MichaelADyerLab: A small molecule targeting STAT3 was shown to experimentally treat AML in vivo. This new molecule could be a useful to…
RT @MichaelADyerLab: A small molecule targeting STAT3 was shown to experimentally treat AML in vivo. This new molecule could be a useful to…
RT @MichaelADyerLab: A small molecule targeting STAT3 was shown to experimentally treat AML in vivo. This new molecule could be a useful to…
RT @MichaelADyerLab: A small molecule targeting STAT3 was shown to experimentally treat AML in vivo. This new molecule could be a useful to…
RT @DrAnasYounes: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo https://t.co/Dvowi4axgn
A small molecule targeting STAT3 was shown to experimentally treat AML in vivo. This new molecule could be a useful tool and potential therapeutic option, even when STAT3 is mutated! Check it out in @Cancer_Cell #ChildhoodCancer @StJudeResearch https://t.c
RT @DrAnasYounes: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo https://t.co/Dvowi4axgn
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo https://t.co/Dvowi4axgn
RT @sommerjo: Brachyury is next thanks to the amazing work of @CraigMCrews @DanNomura @Ogileadi @dhdrewry @chasz43 @HadleySheppard @PaulWor…
RT @HartungIngo: 280 characters about the impressive study of STAT3 #PROTACs from the Wang lab: inhibitor selectivity gets once again poten…
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
RT @sommerjo: Brachyury is next thanks to the amazing work of @CraigMCrews @DanNomura @Ogileadi @dhdrewry @chasz43 @HadleySheppard @PaulWor…
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
RT @sommerjo: Brachyury is next thanks to the amazing work of @CraigMCrews @DanNomura @Ogileadi @dhdrewry @chasz43 @HadleySheppard @PaulWor…
RT @sommerjo: Brachyury is next thanks to the amazing work of @CraigMCrews @DanNomura @Ogileadi @dhdrewry @chasz43 @HadleySheppard @PaulWor…
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
Degradation as an MoA is such a game changer. Rethinks everything from pk/pd to durability of phenotypes to what targets are in play in the first place!
Brachyury is next thanks to the amazing work of @CraigMCrews @DanNomura @Ogileadi @dhdrewry @chasz43 @HadleySheppard @PaulWorkmanICR @SchreiberStuart @TSharifnia
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
RT @HartungIngo: 280 characters about the impressive study of STAT3 #PROTACs from the Wang lab: inhibitor selectivity gets once again poten…
RT @gedefo_sefh: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo https://t.co/OYZSn2FbdE
RT @HartungIngo: 280 characters about the impressive study of STAT3 #PROTACs from the Wang lab: inhibitor selectivity gets once again poten…
RT @HartungIngo: 280 characters about the impressive study of STAT3 #PROTACs from the Wang lab: inhibitor selectivity gets once again poten…
RT @HartungIngo: 280 characters about the impressive study of STAT3 #PROTACs from the Wang lab: inhibitor selectivity gets once again poten…
RT @HartungIngo: 280 characters about the impressive study of STAT3 #PROTACs from the Wang lab: inhibitor selectivity gets once again poten…
RT @HartungIngo: 280 characters about the impressive study of STAT3 #PROTACs from the Wang lab: inhibitor selectivity gets once again poten…
RT @HartungIngo: 280 characters about the impressive study of STAT3 #PROTACs from the Wang lab: inhibitor selectivity gets once again poten…
280 characters about the impressive study of STAT3 #PROTACs from the Wang lab: inhibitor selectivity gets once again potentiated; the promise of conquering undruggable targets gets fulfilled; certain targets don't need once-daily oral dosing @CellCellPress
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo https://t.co/OYZSn2FbdE
RT @adammgilbert911: Exciting STAT3 PROTACs from Shaomeng Wang's lab with excellent efficacy against leukemias and lymphomas #proteindegrad…
RT @adammgilbert911: Exciting STAT3 PROTACs from Shaomeng Wang's lab with excellent efficacy against leukemias and lymphomas #proteindegrad…
Buenas noticias en el frente de batalla contra la #leucemia y el #linfoma - A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo: Cancer Cell https://t.co/BtjNAbV9ev
🔬 A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. 📝 Cancer Cell. 👨🏻🔬 Bai L, et al. 🌎 https://t.co/KssreWeDyX #science #research https://t.co/ujpl4xL5rY
RT @georg_e_winter: The chemistry- and drug discovery efforts of Shaomeng Wang's lab continue to be incredibly impressive. Beautiful work o…
The chemistry- and drug discovery efforts of Shaomeng Wang's lab continue to be incredibly impressive. Beautiful work on STAT3 degraders with impressive in vivo efficacy despite considerable https://t.co/uR2AxOjU9c @Cancer_Cell
#Leukemia🦀 #lymphoma🦀: #STAT3 is a target to treat these tumors. The #SD36 molecule degrades STAT3 #invitro🔬 and #invivo🐁 and it permanently eliminates tumors in several models #xenografted mice🐁 (transplanted human tumors) 👍 https://t.co/e6NC7smyqy https:
🔬 A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. 📝 Cancer Cell. 👨🏻🔬 Bai L, et al. 🌎 https://t.co/KssreWeDyX #science #research https://t.co/CFaJr1DP8j
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo https://t.co/3ZaKMzJwlu
🔬 A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. 📝 Cancer Cell. 👨🏻🔬 Bai L, et al. 🌎 https://t.co/KssreWeDyX #science #research https://t.co/E5vT6qqvMD
RT @recherche_anima: #Leucémie🦀 #lymphome🦀: #STAT3 est une cible pour traiter ces tumeurs. La molécule #SD36 dégrade STAT3 #invitro🔬 et #in…
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
Truly impressive to see the small molecule target space expand so dramatically in the past few years and open up new #Immunotherapy approaches.
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. #lymphoma #lymsm https://t.co/9DGCcTZADm
New article: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. https://t.co/jOx3znhYel #AML #leusm #hematology
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
Good to see innovation marching along amidst all the noise.
RT @AndyBiotech: One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targe…
One step closer to check STAT3 off the “Undruggable” list? Inhibit vs Destroy: Are PROTAC Degraders the Solution to Targeting STAT3? https://t.co/JFUNJf0qE7 A Potent & Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In V
RT @Cancer_Cell: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo @UMRogelCancer https://…
RT @Cancer_Cell: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo @UMRogelCancer https://…
RT @Cancer_Cell: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo @UMRogelCancer https://…
RT @Cancer_Cell: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo @UMRogelCancer https://…
So degrader does work in animal models.
RT @Cancer_Cell: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo @UMRogelCancer https://…
RT @Cancer_Cell: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo @UMRogelCancer https://…
RT @Cancer_Cell: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo @UMRogelCancer https://…
RT @drleighellis: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo: Cancer Cell https://t…
RT @Cancer_Cell: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo @UMRogelCancer https://…
RT @UMRogelCancer: Just out in @Cancer_Cell: A STAT3 degrader compound developed by a @umichmedicine / @UMichPharmacy / @UMLifeSciences tea…
RT @platten_michael: This study shows the power of #PROTAC (proteolysis targeting chimera) in targeting intracellular #immune #checkpoints…
RT @adammgilbert911: Exciting STAT3 PROTACs from Shaomeng Wang's lab with excellent efficacy against leukemias and lymphomas #proteindegrad…
RT @Cancer_Cell: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo @UMRogelCancer https://…
RT @adammgilbert911: Exciting STAT3 PROTACs from Shaomeng Wang's lab with excellent efficacy against leukemias and lymphomas #proteindegrad…
RT @platten_michael: This study shows the power of #PROTAC (proteolysis targeting chimera) in targeting intracellular #immune #checkpoints…
RT @Cancer_Cell: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo @UMRogelCancer https://…
RT @Cancer_Cell: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo @UMRogelCancer https://…
This study shows the power of #PROTAC (proteolysis targeting chimera) in targeting intracellular #immune #checkpoints with small molecules also for #cancer #immunotherapy.
RT @Cancer_Cell: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo @UMRogelCancer https://…
RT @recherche_anima: #Leucémie🦀 #lymphome🦀: #STAT3 est une cible pour traiter ces tumeurs. La molécule #SD36 dégrade STAT3 #invitro🔬 et #in…
RT @Cancer_Cell: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo @UMRogelCancer https://…
Amazing work from Dr. Zhaomeng Wang’s team https://t.co/2ySuzfVcmi https://t.co/4A74AnN22D
#Leucémie🦀 #lymphome🦀: #STAT3 est une cible pour traiter ces tumeurs. La molécule #SD36 dégrade STAT3 #invitro🔬 et #invivo🐁 😮. Elle élimine durablement les tumeurs sur plusieurs modèles #souris de xénogreffe (greffe de tumeur humaine)👍 https://t.co/e6NC7sm
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Compl... https://t.co/0lFF4nzegC
RT @Cancer_Cell: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo @UMRogelCancer https://…
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo: Cancer Cell https://t.co/RIln13Y3TF
RT @Cancer_Cell: A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo @UMRogelCancer https://…