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Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders

Overview of attention for article published in Journal of Medicinal Chemistry, September 2019
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

twitter
22 tweeters

Citations

dimensions_citation
15 Dimensions

Readers on

mendeley
100 Mendeley
Title
Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders
Published in
Journal of Medicinal Chemistry, September 2019
DOI 10.1021/acs.jmedchem.9b00846
Pubmed ID
Authors

Jiuling Yang, Yangbing Li, Angelo Aguilar, Zhaomin Liu, Chao-Yie Yang, Shaomeng Wang

Twitter Demographics

The data shown below were collected from the profiles of 22 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 100 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 33 33%
Student > Ph. D. Student 27 27%
Student > Master 8 8%
Other 5 5%
Professor > Associate Professor 5 5%
Other 12 12%
Unknown 10 10%
Readers by discipline Count As %
Chemistry 46 46%
Biochemistry, Genetics and Molecular Biology 15 15%
Agricultural and Biological Sciences 11 11%
Pharmacology, Toxicology and Pharmaceutical Science 7 7%
Medicine and Dentistry 2 2%
Other 3 3%
Unknown 16 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2020.
All research outputs
#1,817,749
of 15,377,318 outputs
Outputs from Journal of Medicinal Chemistry
#1,385
of 19,195 outputs
Outputs of similar age
#49,300
of 268,620 outputs
Outputs of similar age from Journal of Medicinal Chemistry
#21
of 96 outputs
Altmetric has tracked 15,377,318 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 19,195 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,620 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.