| Title |
Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders
|
|---|---|
| Published in |
Journal of Medicinal Chemistry, September 2019
|
| DOI | 10.1021/acs.jmedchem.9b00846 |
| Pubmed ID | |
| Authors |
Jiuling Yang, Yangbing Li, Angelo Aguilar, Zhaomin Liu, Chao-Yie Yang, Shaomeng Wang |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 36% |
| Germany | 3 | 14% |
| United Kingdom | 1 | 5% |
| Côte d'Ivoire | 1 | 5% |
| Belgium | 1 | 5% |
| Switzerland | 1 | 5% |
| Canada | 1 | 5% |
| Unknown | 6 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 14 | 64% |
| Members of the public | 7 | 32% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 193 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 49 | 25% |
| Student > Ph. D. Student | 38 | 20% |
| Other | 11 | 6% |
| Student > Master | 10 | 5% |
| Professor | 8 | 4% |
| Other | 25 | 13% |
| Unknown | 52 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 68 | 35% |
| Biochemistry, Genetics and Molecular Biology | 27 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 7% |
| Agricultural and Biological Sciences | 12 | 6% |
| Medicine and Dentistry | 4 | 2% |
| Other | 9 | 5% |
| Unknown | 60 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2024.
All research outputs
#2,538,780
of 25,440,205 outputs
Outputs from Journal of Medicinal Chemistry
#1,670
of 23,177 outputs
Outputs of similar age
#51,852
of 358,856 outputs
Outputs of similar age from Journal of Medicinal Chemistry
#24
of 155 outputs
Altmetric has tracked 25,440,205 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 23,177 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 358,856 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 155 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.