Title |
The microbiome and critical illness
|
---|---|
Published in |
The Lancet Respiratory Medicine, December 2015
|
DOI | 10.1016/s2213-2600(15)00427-0 |
Pubmed ID | |
Authors |
Robert P Dickson |
Abstract |
The central role of the microbiome in critical illness is supported by a half century of experimental and clinical study. The physiological effects of critical illness and the clinical interventions of intensive care substantially alter the microbiome. In turn, the microbiome predicts patients' susceptibility to disease, and manipulation of the microbiome has prevented or modulated critical illness in animal models and clinical trials. This Review surveys the microbial ecology of critically ill patients, presents the facts and unanswered questions surrounding gut-derived sepsis, and explores the radically altered ecosystem of the injured alveolus. The revolution in culture-independent microbiology has provided the tools needed to target the microbiome rationally for the prevention and treatment of critical illness, holding great promise to improve the acute and chronic outcomes of the critically ill. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 23 | 26% |
United States | 8 | 9% |
Switzerland | 2 | 2% |
Spain | 2 | 2% |
France | 2 | 2% |
South Africa | 2 | 2% |
Venezuela, Bolivarian Republic of | 2 | 2% |
India | 1 | 1% |
Singapore | 1 | 1% |
Other | 8 | 9% |
Unknown | 38 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 55 | 62% |
Practitioners (doctors, other healthcare professionals) | 18 | 20% |
Scientists | 14 | 16% |
Science communicators (journalists, bloggers, editors) | 2 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
India | 1 | <1% |
Greece | 1 | <1% |
Australia | 1 | <1% |
Unknown | 362 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 49 | 13% |
Researcher | 47 | 13% |
Student > Master | 36 | 10% |
Other | 31 | 8% |
Student > Bachelor | 26 | 7% |
Other | 72 | 20% |
Unknown | 105 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 114 | 31% |
Agricultural and Biological Sciences | 38 | 10% |
Biochemistry, Genetics and Molecular Biology | 24 | 7% |
Immunology and Microbiology | 24 | 7% |
Nursing and Health Professions | 15 | 4% |
Other | 32 | 9% |
Unknown | 119 | 33% |