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Metformin reverses established lung fibrosis in a bleomycin model

Overview of attention for article published in Nature Medicine, July 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

news
21 news outlets
twitter
198 tweeters
facebook
6 Facebook pages
googleplus
1 Google+ user
reddit
1 Redditor

Citations

dimensions_citation
6 Dimensions

Readers on

mendeley
82 Mendeley
citeulike
1 CiteULike
Title
Metformin reverses established lung fibrosis in a bleomycin model
Published in
Nature Medicine, July 2018
DOI 10.1038/s41591-018-0087-6
Pubmed ID
Authors

Sunad Rangarajan, Nathaniel B. Bone, Anna A. Zmijewska, Shaoning Jiang, Dae Won Park, Karen Bernard, Morgan L. Locy, Saranya Ravi, Jessy Deshane, Roslyn B. Mannon, Edward Abraham, Victor Darley-Usmar, Victor J. Thannickal, Jaroslaw W. Zmijewski

Abstract

Fibrosis is a pathological result of a dysfunctional repair response to tissue injury and occurs in a number of organs, including the lungs1. Cellular metabolism regulates tissue repair and remodelling responses to injury2-4. AMPK is a critical sensor of cellular bioenergetics and controls the switch from anabolic to catabolic metabolism5. However, the role of AMPK in fibrosis is not well understood. Here, we demonstrate that in humans with idiopathic pulmonary fibrosis (IPF) and in an experimental mouse model of lung fibrosis, AMPK activity is lower in fibrotic regions associated with metabolically active and apoptosis-resistant myofibroblasts. Pharmacological activation of AMPK in myofibroblasts from lungs of humans with IPF display lower fibrotic activity, along with enhanced mitochondrial biogenesis and normalization of sensitivity to apoptosis. In a bleomycin model of lung fibrosis in mice, metformin therapeutically accelerates the resolution of well-established fibrosis in an AMPK-dependent manner. These studies implicate deficient AMPK activation in non-resolving, pathologic fibrotic processes, and support a role for metformin (or other AMPK activators) to reverse established fibrosis by facilitating deactivation and apoptosis of myofibroblasts.

Twitter Demographics

The data shown below were collected from the profiles of 198 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 82 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 26 32%
Student > Ph. D. Student 20 24%
Other 9 11%
Professor > Associate Professor 6 7%
Student > Master 5 6%
Other 16 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 23%
Medicine and Dentistry 16 20%
Biochemistry, Genetics and Molecular Biology 15 18%
Unspecified 14 17%
Immunology and Microbiology 10 12%
Other 8 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 276. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2018.
All research outputs
#36,182
of 12,140,823 outputs
Outputs from Nature Medicine
#105
of 6,313 outputs
Outputs of similar age
#1,806
of 246,195 outputs
Outputs of similar age from Nature Medicine
#18
of 116 outputs
Altmetric has tracked 12,140,823 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,313 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.3. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,195 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 116 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.