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Extracellular vesicles direct migration by synthesizing and releasing chemotactic signals

Overview of attention for article published in Journal of Cell Biology, June 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Citations

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2 Dimensions

Readers on

mendeley
28 Mendeley
Title
Extracellular vesicles direct migration by synthesizing and releasing chemotactic signals
Published in
Journal of Cell Biology, June 2018
DOI 10.1083/jcb.201710170
Pubmed ID
Authors

Paul W. Kriebel, Ritankar Majumdar, Lisa M. Jenkins, Hiroshi Senoo, Weiye Wang, Sonia Ammu, Song Chen, Kedar Narayan, Miho Iijima, Carole A. Parent, Kriebel PW, Majumdar R, Jenkins LM, Senoo H, Wang W, Ammu S, Chen S, Narayan K, Iijima M, Parent CA

Abstract

Chemotactic signals are relayed to neighboring cells through the secretion of additional chemoattractants. We previously showed in Dictyostelium discoideum that the adenylyl cyclase A, which synthesizes the chemoattractant cyclic adenosine monophosphate (cAMP), is present in the intraluminal vesicles of multivesicular bodies (MVBs) that coalesce at the back of cells. Using ultrastructural reconstructions, we now show that ACA-containing MVBs release their contents to attract neighboring cells. We show that the released vesicles are capable of directing migration and streaming and are central to chemotactic signal relay. We demonstrate that the released vesicles not only contain cAMP but also can actively synthesize and release cAMP to promote chemotaxis. Through proteomic, pharmacological, and genetic approaches, we determined that the vesicular cAMP is released via the ABCC8 transporter. Together, our findings show that extracellular vesicles released by Ddiscoideum cells are functional entities that mediate signal relay during chemotaxis and streaming.

Twitter Demographics

The data shown below were collected from the profiles of 68 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 43%
Researcher 3 11%
Student > Doctoral Student 3 11%
Unspecified 3 11%
Student > Bachelor 2 7%
Other 5 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 50%
Agricultural and Biological Sciences 6 21%
Unspecified 3 11%
Physics and Astronomy 1 4%
Immunology and Microbiology 1 4%
Other 3 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2018.
All research outputs
#369,802
of 11,927,896 outputs
Outputs from Journal of Cell Biology
#190
of 9,373 outputs
Outputs of similar age
#17,034
of 253,840 outputs
Outputs of similar age from Journal of Cell Biology
#18
of 77 outputs
Altmetric has tracked 11,927,896 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,373 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 253,840 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.