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Sudden Death in Heart Failure with Preserved Ejection Fraction: A Competing Risks Analysis from the TOPCAT Trial

Overview of attention for article published in JACC: Heart Failure, March 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

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112 tweeters
facebook
1 Facebook page

Citations

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5 Dimensions

Readers on

mendeley
24 Mendeley
Title
Sudden Death in Heart Failure with Preserved Ejection Fraction: A Competing Risks Analysis from the TOPCAT Trial
Published in
JACC: Heart Failure, March 2018
DOI 10.1016/j.jchf.2018.02.014
Pubmed ID
Authors

Muthiah Vaduganathan, Brian L. Claggett, Neal A. Chatterjee, Inder S. Anand, Nancy K. Sweitzer, James C. Fang, Eileen O'Meara, Sanjiv J. Shah, Sheila M. Hegde, Akshay S. Desai, Eldrin F. Lewis, Jean Rouleau, Bertram Pitt, Marc A. Pfeffer, Scott D. Solomon

Abstract

Sudden death (SD) may be an important mode of death in heart failure with preserved ejection fraction (HFpEF). To investigate rates and predictors of SD or aborted cardiac arrest (ACA) in HFpEF. We studied 1,767 patients with HFpEF (EF≥45%) enrolled in the Americas region of the TOPCAT trial. We identified independent predictors of composite SD/ACA with step-wise backward selection using competing risks regression analysis accounting for non-sudden causes of death. During median 3.0 (1.9-4.4) year follow-up, 77 patients experienced SD/ACA and 312 experienced non-SD/ACA. Corresponding incidence rates were 1.4 (1.1-1.8) and 5.8 (5.1-6.4) events/100 patient-years. SD/ACA was numerically lower but not statistically reduced in those randomized to spironolactone: 1.2 (0.9-1.7) vs. 1.6 (1.2-2.2) events/100 patient-years; subdistributional HR 0.74 95% CI 0.47-1.16; P=0.19. After accounting for competing risks of non-sudden death, male sex and insulin-treated diabetes mellitus were independently predictive of composite SD/ACA (C-statistic 0.65). Covariates-including eligibility criteria, age, ejection fraction, coronary artery disease, LBBB, and baseline therapies-were not independently associated with SD/ACA. Sex and diabetes mellitus status remained independent predictors in sensitivity analyses excluding patients with implantable cardioverter-defibrillators and when predicting SD alone. SD accounted for ∼20% of deaths in HFpEF. Male sex and insulin-treated diabetes mellitus identify patients at higher risk for SD/ACA with modest discrimination. These data may guide future SD-preventative efforts in HFpEF. TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist); ClinicalTrials.gov Unique Identifier: NCT00094302.

Twitter Demographics

The data shown below were collected from the profiles of 112 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 25%
Unspecified 3 13%
Professor 3 13%
Other 3 13%
Student > Master 2 8%
Other 7 29%
Readers by discipline Count As %
Medicine and Dentistry 13 54%
Unspecified 7 29%
Agricultural and Biological Sciences 1 4%
Psychology 1 4%
Immunology and Microbiology 1 4%
Other 1 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 63. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2018.
All research outputs
#221,736
of 12,140,972 outputs
Outputs from JACC: Heart Failure
#56
of 710 outputs
Outputs of similar age
#11,638
of 270,489 outputs
Outputs of similar age from JACC: Heart Failure
#7
of 39 outputs
Altmetric has tracked 12,140,972 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 710 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.2. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,489 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.