Title |
Transcriptional and post-transcriptional regulation of autophagy in the yeast Saccharomyces cerevisiae
|
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Published in |
Journal of Biological Chemistry, January 2018
|
DOI | 10.1074/jbc.r117.804641 |
Pubmed ID | |
Authors |
Elizabeth Delorme-Axford, Daniel J Klionsky |
Abstract |
Autophagy is a highly conserved catabolic pathway that is vital for development, cell survival and the degradation of dysfunctional organelles and toxic aggregates. Dysregulation of autophagy is associated with cancer, neurodegeneration and lysosomal storage diseases. Accordingly, autophagy is precisely regulated at multiple levels (transcriptional, post-transcriptional, epigenetic, translational and post-translational) to prevent aberrant activity. Various model organisms exist to study autophagy but the baker's yeast Saccharomyces cerevisiae continues to be very advantageous for genetic and biochemical analysis of non-selective and selective autophagy. In this review, we focus on the cellular mechanisms that regulate autophagy transcriptionally and post-transcriptionally in S. cerevisiae. |
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Geographical breakdown
Country | Count | As % |
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United States | 5 | 42% |
United Kingdom | 2 | 17% |
Nigeria | 1 | 8% |
Germany | 1 | 8% |
Mexico | 1 | 8% |
Unknown | 2 | 17% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 50% |
Scientists | 6 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 89 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 28 | 31% |
Student > Bachelor | 14 | 16% |
Researcher | 10 | 11% |
Student > Doctoral Student | 6 | 7% |
Student > Master | 5 | 6% |
Other | 5 | 6% |
Unknown | 21 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 39 | 44% |
Agricultural and Biological Sciences | 19 | 21% |
Immunology and Microbiology | 3 | 3% |
Medicine and Dentistry | 3 | 3% |
Computer Science | 1 | 1% |
Other | 2 | 2% |
Unknown | 22 | 25% |