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Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia

Overview of attention for article published in New England Journal of Medicine, December 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Citations

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111 Dimensions

Readers on

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259 Mendeley
Title
Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia
Published in
New England Journal of Medicine, December 2017
DOI 10.1056/nejmoa1613773
Pubmed ID
Authors

Phillip S. Cuculich, Matthew R. Schill, Rojano Kashani, Sasa Mutic, Adam Lang, Daniel Cooper, Mitchell Faddis, Marye Gleva, Amit Noheria, Timothy W. Smith, Dennis Hallahan, Yoram Rudy, Clifford G. Robinson

Abstract

Background Recent advances have enabled noninvasive mapping of cardiac arrhythmias with electrocardiographic imaging and noninvasive delivery of precise ablative radiation with stereotactic body radiation therapy (SBRT). We combined these techniques to perform catheter-free, electrophysiology-guided, noninvasive cardiac radioablation for ventricular tachycardia. Methods We targeted arrhythmogenic scar regions by combining anatomical imaging with noninvasive electrocardiographic imaging during ventricular tachycardia that was induced by means of an implantable cardioverter-defibrillator (ICD). SBRT simulation, planning, and treatments were performed with the use of standard techniques. Patients were treated with a single fraction of 25 Gy while awake. Efficacy was assessed by counting episodes of ventricular tachycardia, as recorded by ICDs. Safety was assessed by means of serial cardiac and thoracic imaging. Results From April through November 2015, five patients with high-risk, refractory ventricular tachycardia underwent treatment. The mean noninvasive ablation time was 14 minutes (range, 11 to 18). During the 3 months before treatment, the patients had a combined history of 6577 episodes of ventricular tachycardia. During a 6-week postablation "blanking period" (when arrhythmias may occur owing to postablation inflammation), there were 680 episodes of ventricular tachycardia. After the 6-week blanking period, there were 4 episodes of ventricular tachycardia over the next 46 patient-months, for a reduction from baseline of 99.9%. A reduction in episodes of ventricular tachycardia occurred in all five patients. The mean left ventricular ejection fraction did not decrease with treatment. At 3 months, adjacent lung showed opacities consistent with mild inflammatory changes, which had resolved by 1 year. Conclusions In five patients with refractory ventricular tachycardia, noninvasive treatment with electrophysiology-guided cardiac radioablation markedly reduced the burden of ventricular tachycardia. (Funded by Barnes-Jewish Hospital Foundation and others.).

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 259 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 259 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 62 24%
Other 39 15%
Student > Ph. D. Student 30 12%
Professor > Associate Professor 17 7%
Student > Doctoral Student 17 7%
Other 58 22%
Unknown 36 14%
Readers by discipline Count As %
Medicine and Dentistry 128 49%
Engineering 12 5%
Agricultural and Biological Sciences 11 4%
Physics and Astronomy 10 4%
Biochemistry, Genetics and Molecular Biology 5 2%
Other 19 7%
Unknown 74 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 778. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2020.
All research outputs
#7,705
of 14,380,539 outputs
Outputs from New England Journal of Medicine
#397
of 26,127 outputs
Outputs of similar age
#424
of 399,873 outputs
Outputs of similar age from New England Journal of Medicine
#25
of 268 outputs
Altmetric has tracked 14,380,539 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 26,127 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 67.9. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 399,873 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 268 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.