RT @doctorveera: Note the highest peak is at ACAN locus that has the largest effect size of all. Because it's tagging a VNTR. This is one o…
Note the highest peak is at ACAN locus that has the largest effect size of all. Because it's tagging a VNTR. This is one of my favorite stories that I'll be never get tired of repeating. https://t.co/0GGRc2A6bj
The same concept applied to a height GWAS illustrating that it's not possible to guess effect sizes based on a Manhattan plot. https://t.co/0GGRc2RHzT
I am suprised that neither in the Europeans GWAS (https://t.co/5JjeNFQ1vR) nor in the current Africans GWAS, the authors cared about which locus shows the largest effect size and if it informs anything about the biology of height. 🤷♂️
@NPirastu Thanks for the explanation. But I haven't come across variants showing large effect size but not biologically important. Here is an another example supporting my view. https://t.co/0GGRc2RHzT
The GWAS from GIANT consortium published in 2010 reported 180 loci associated with height. Our locus of interest here is the one at chromosome 15 (red square) https://t.co/5JjeNFQ1vR https://t.co/2GAbBFGa23
13 out of 21 = 62%, very close to the ~65% I quoted above Here's the link to the GIANT paper: https://t.co/AVN9e1QKEz
RT @timfrayling: @Eric_Fauman yep, despite potential of long range interactions, GWAS signals are usually close to likely causal gene - hei…
RT @timfrayling: @Eric_Fauman yep, despite potential of long range interactions, GWAS signals are usually close to likely causal gene - hei…
@Eric_Fauman yep, despite potential of long range interactions, GWAS signals are usually close to likely causal gene - height signals hit monogenic skeletal disorder genes, also shown for lipids: https://t.co/cu6labCd5J
Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature... https://t.co/yj4cH9WTuW
Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature https://t.co/2PNeLx37Lr
@oxfordhacker "we show that hundreds of genetic variants, in at least 180 loci, influence adult height” http://t.co/nYNP0R3qaz
Slate: #GWAS of human height http://t.co/MzS8H5VRWB #iEOS2014
@tossijp こっから、文献をたどっていったらいいんじゃない?http://t.co/bVQAZAjcWH
@SarahHCarl Looking at this publication: http://t.co/zjDSwPCxft They already identified the SNPs from the GWAS meta-analysis.
Thanks hivemind! I think this is the winner for now. RT @joe_pickrell: @girlscientist Height? 180,000. http://t.co/iwuRPTbx
@girlscientist Height? 180,000. http://t.co/mTLsXCrC