Ezogabine decreased cortical and spinal motor neuron excitability in participants with ALS, suggesting that such neurophysiological metrics may be used as pharmacodynamic biomarkers in multisite clinical trials. https://t.co/BjEV7VF68v via @JAMANeuro
@cornuammonis1 @BWJones @brainstimgrl We used it recently as a readout in a clinical trial for ALS (unsure if this helps, but i can't hurt). https://t.co/OPeL4UMV6L
Woa, biggest COI ever? https://t.co/zMsWy0Z3iP https://t.co/wylylxmO4u
RT @JAMANeuro: Randomized, double-blind, placebo-controlled phase 2 trial finds the potassium channel activator ezogabine reduces cortical…
Randomized, double-blind, placebo-controlled phase 2 trial finds the potassium channel activator ezogabine reduces cortical and spinal motor neuron excitability in participants with #ALS https://t.co/3vYkI3JOwY
A recent study investigated the effect of Ezogabine on cortical and spinal motor neurons excitability in patient with ALS. Can TMS-based pharmacodynamic biomarkers help to accelerate the pace of novel drug discovery? https://t.co/wvhOpZOlGC #TMS #ALS #EMG
RT @DrJohanLim: 1. Can ezogabine reduce cortical and spinal motor neuron excitability in amyotrophic lateral sclerosis/#ALS? A RCT @MassGe…
1. Can ezogabine reduce cortical and spinal motor neuron excitability in amyotrophic lateral sclerosis/#ALS? A RCT @MassGeneralNews to investigate this question out now @JAMANeuro https://t.co/FixamLBFvr https://t.co/tNbaPEozOJ
RT @JAMANeuro: Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis https://t.co/mh32fTUeIr
RT @JAMANeuro: Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis https://t.co/mh32fTUeIr
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis https://t.co/mh32fTUeIr
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis - JAMA Neurology Jour. via BrainSights for iOS https://t.co/HCk56T6GDM
RT @Kirkeby_Lab: Great to see in @JAMANeuro the results from the placebo-controlled clinical trial of Ezogabine in ALS patients. This is in…
RT @Kirkeby_Lab: Great to see in @JAMANeuro the results from the placebo-controlled clinical trial of Ezogabine in ALS patients. This is in…
RT @Kirkeby_Lab: Great to see in @JAMANeuro the results from the placebo-controlled clinical trial of Ezogabine in ALS patients. This is in…
Great to see in @JAMANeuro the results from the placebo-controlled clinical trial of Ezogabine in ALS patients. This is in my view the first example of drug development in patient-derived hiPSCs leading to successful clinical trial outcome. https://t.co/j6
RT @JAMANeuro: Randomized, double-blind, placebo-controlled phase 2 trial finds the potassium channel activator ezogabine reduces cortical…
RT @JAMANeuro: Randomized, double-blind, placebo-controlled phase 2 trial finds the potassium channel activator ezogabine reduces cortical…
Randomized, double-blind, placebo-controlled phase 2 trial finds the potassium channel activator ezogabine reduces cortical and spinal motor neuron excitability in participants with #ALS https://t.co/ZoqSxKgcbK
Ezogabina disminuiría excitab cortical y de neurona motora espinal en escler lat amiotrófica, sugiriendo q estas métricas neurofisiológicas podrían usarse como biomarcadores farmacodinámicos en ensayos clínicos https://t.co/64ujFSBdlr a través de @JAMANeur
RT @NeurologyToday: .@JAMANeuro This randomized trial that includes 65 participants with #amyotrophiclateralsclerosis, suggests that treatm…
RT @NeurologyToday: .@JAMANeuro This randomized trial that includes 65 participants with #amyotrophiclateralsclerosis, suggests that treatm…
.@JAMANeuro This randomized trial that includes 65 participants with #amyotrophiclateralsclerosis, suggests that treatment with ezogabine lowered both spinal and cortical motor neuron excitability in a dose-dependent manner. #neurology @MassGeneralNews htt
Thankful for mentors who taught me TMS and for the opportunity to meet many amazing patients whose lives were sideswiped by this horrible disease. #ALS https://t.co/VfG8ZASvTU via @JAMANeuro part of @JAMANetwork
Phase 2まではALSFRS-Rなど臨床的指標以外をprimary outcomeに設定する試験が増えている。 Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized… https://t.co/PepO7G367l
RT @RoetKasper: Exciting #ALS news in @JAMANeuro – a clinical study by #QurAlis founders of Kv7 agonism shows promising data which suggests…
RT @RoetKasper: Exciting #ALS news in @JAMANeuro – a clinical study by #QurAlis founders of Kv7 agonism shows promising data which suggests…
Congratulations #QurAlis founders Kevin Eggan and Clifford Woolf and Dr Brian Wainger and Dr Merit Cudkowicz with this groundbreaking study translating finding in human stem cells to ALS patients! https://t.co/eCWWciSL5R
Exciting #ALS news in @JAMANeuro – a clinical study by #QurAlis founders of Kv7 agonism shows promising data which suggests improved outcome in patients experiencing motor neuron hyperexcitability. A major milestone in developing treatments for ALS: https:
A new clinical study in @JAMANeuro suggests that #Kv7 agonists like ezogabine could notably improve prognoses for #ALS patients experiencing motor neuron hyperexcitability – exciting news for companies like QurAlis investigating Kv7 in ALS: https://t.co/hG
RT @AmitChaudhariMD: Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis This randomized…
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis This randomized clinical trial examines the use of clinical neurophysiological metrics of excitability as... https://t.co/MiBcBDECNl #neurology #neurosci
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis #Neurology #NeuroTwitter #MedTwitter #MedEd https://t.co/ojMlfu9H5l
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis #Neurology #NeuroTwitter #MedTwitter #MedEd https://t.co/w7oCUoIHjK
RT @JAMANeuro: Randomized, double-blind, placebo-controlled phase 2 trial finds the potassium channel activator ezogabine reduces cortical…
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis https://t.co/rMz576E7YY via @JAMANeuro part of @JAMANetwork
RT @JAMANeuro: Randomized, double-blind, placebo-controlled phase 2 trial finds the potassium channel activator ezogabine reduces cortical…
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis https://t.co/9SwEfa0DQG via @JAMANeuro part of @JAMANetwork
Randomized, double-blind, placebo-controlled phase 2 trial finds the potassium channel activator ezogabine reduces cortical and spinal motor neuron excitability in participants with #ALS https://t.co/HuFHjS6rMc