I have old (even prepandemic) tabs but interesting work led by Alexander Bick (who is now at @VUMChealth on germline mutations being indicative of CHIP. Something I don't hear enough about is how somatic mutations are in the context of germline ones. http
RT @AlexBickMDPhD: Why do >10% of older adults have clonal blood mutations? Simultaneous germline & somatic genome analysis in ~97K pinpoi…
RT @AlexBickMDPhD: Why do >10% of older adults have clonal blood mutations? Simultaneous germline & somatic genome analysis in ~97K pinpoi…
RT @AlexBickMDPhD: Why do >10% of older adults have clonal blood mutations? Simultaneous germline & somatic genome analysis in ~97K pinpoi…
RT @unsi1encedsci: Here is some bad news for longevity research: https://t.co/eYrMRE15jZ
Here is some bad news for longevity research: https://t.co/eYrMRE15jZ
*However,* when we did a GWAS of CHIP in @nih_nhlbi TOPMed, while TERT (telomerase reverse transcriptase) was the lead signal, the CHIP-predisposing allele was also the telomere-lengthening allele! https://t.co/p2BElnivun @Nature @AlexBickMDPhD https://t.c
@i000 This team previously ran a CHIP GWAS (https://t.co/uYwj8WfcU2) with no HLA hits, but could be interesting to look at genetic correlation between the studies. I feel for them wrt potential technical artifacts, not much else you can do but publish and
RT @AlexBickMDPhD: My personal gratitude to @J__Stock for his partnership on so much of our TOPMed #CHIP work. Josh has written TWO first a…
This work helps us understand why some clonal hematopoiesis clones expand much faster than others - one of the key questions that was unresolved after our previous work: https://t.co/GQ4XxKWGlm .
My personal gratitude to @J__Stock for his partnership on so much of our TOPMed #CHIP work. Josh has written TWO first author Nature papers and another forthcoming manuscript in @ScienceAdvances -- a singularly impressive PhD track record! https://t.co/X54
@aidanbutty @stevesphd @KrishnaAragam @AlexBickMDPhD and I were early adopters of tag-team tweetorials! Inspired by others who did it before us.
One reason we looked into this question was because of the interesting observation that rs144418061 SNP near TET2 is found in individuals of African ancestry and results in increased risk of CHIP (not just TET2 variants!) https://t.co/Q9UI318cnj
RT @DrFlashHeart: @SayaliBThakare @NephJC @QMyPath The prevalence of CHIP rises sharply with age (see Fig 1 here: https://t.co/vXgfMDaMIf)…
RT @DrFlashHeart: @SayaliBThakare @NephJC @QMyPath The prevalence of CHIP rises sharply with age (see Fig 1 here: https://t.co/vXgfMDaMIf)…
RT @DrFlashHeart: @SayaliBThakare @NephJC @QMyPath The prevalence of CHIP rises sharply with age (see Fig 1 here: https://t.co/vXgfMDaMIf)…
RT @DrFlashHeart: @SayaliBThakare @NephJC @QMyPath The prevalence of CHIP rises sharply with age (see Fig 1 here: https://t.co/vXgfMDaMIf)…
RT @DrFlashHeart: @SayaliBThakare @NephJC @QMyPath The prevalence of CHIP rises sharply with age (see Fig 1 here: https://t.co/vXgfMDaMIf)…
@SayaliBThakare @NephJC @QMyPath The prevalence of CHIP rises sharply with age (see Fig 1 here: https://t.co/vXgfMDaMIf) There was an interesting report of CHIP in a 111-year old woman that suggested that CHIP may have conferred robust T-cell immunity. ht
6. TET2 locus for clonal hematopoiesis https://t.co/W9JSzL4zLm
@UrnovFyodor @jaiswalmdphd Yes, as @AlexBickMDPhD and @pnatarajanmd described in their original #TOPMed analysis: https://t.co/K2m7c8JquC
@GENES_PK 1. TET2 - clonal hematopoiesis (+ African ancestry specific locus) https://t.co/gCncvyvIGK
Another. Okay, I'll stop here :) https://t.co/W9JSzKMYTO https://t.co/5lsW7wN5Zf
Inherited causes of clonal haematopoiesis in 97,691 whole genomes. https://t.co/2louYVVGUD
Inherited causes of clonal haematopoiesis in 97,691 whole genomes. https://t.co/2VHjWd4LUr https://t.co/OLwuiiaAWB
In the second paper, Bick et al discovered how a noncoding variant adjacent to TET2 leads to clonal hematopoeisis (age related accumulation of somatic mutation in circulating blood cells) https://t.co/gCncvyNk5k
@Eric_Fauman @bloodgenes @zekavatm @AlexBickMDPhD @freeseek82 Functional work led by @bloodgenes in https://t.co/S80k26o7Ur supports this as a causal gene for CHIP
@Eric_Fauman Sorry - too many "CHIP" acronyms. Probably not in LD with the AA-specific variant here https://t.co/p2BEln0mgf @AlexBickMDPhD. Worth seeing if it has supportive assocs w CHIP or mosaic chr alterations (latter being lymphoid-related - https://t
Inherited causes of clonal haematopoiesis in 97,691 whole genomes @pnatarajanmd @nature https://t.co/3wohSgAI0u
RT @bloodgenes: Great presentation from Dr. Bhatnagar at #ASH20 - Much to study about worse outcomes of young Black AML patients... ? Is th…
RT @bloodgenes: Great presentation from Dr. Bhatnagar at #ASH20 - Much to study about worse outcomes of young Black AML patients... ? Is th…
RT @bloodgenes: Great presentation from Dr. Bhatnagar at #ASH20 - Much to study about worse outcomes of young Black AML patients... ? Is th…
RT @bloodgenes: Great presentation from Dr. Bhatnagar at #ASH20 - Much to study about worse outcomes of young Black AML patients... ? Is th…
RT @bloodgenes: Great presentation from Dr. Bhatnagar at #ASH20 - Much to study about worse outcomes of young Black AML patients... ? Is th…
Great presentation from Dr. Bhatnagar at #ASH20 - Much to study about worse outcomes of young Black AML patients... ? Is there more biology to study, as nicely illustrated for CHIP in this recent study (https://t.co/BBsrag3lqr)? https://t.co/Q0BM1uIWqB
@TDCapellini @GeneticsGSA @GeneticsSociety @eshgsociety @AAAGenetics @GWAS_lit The TET2 locus work from https://t.co/SHH40jO3x6 @AlexBickMDPhD et al is good very recent example
RT @UM_Genetics: DNA sequencing tech developed in the Kitzman lab @jacobkitzman powers part of a large-scale study of somatic mutations rel…
RT @AlexBickMDPhD: Why do >10% of older adults have clonal blood mutations? Simultaneous germline & somatic genome analysis in ~97K pinpoi…
RT @NatureGenet: Online @nature Inherited causes of clonal haematopoiesis in 97,691 whole genomes https://t.co/0bScLL1bx9 https://t.co/BTWc…
Las variantes de la línea germinal contribuyen al riesgo de desarrollar hematopoyesis clonal relacionada con el envejecimiento. https://t.co/vV4U6bcF8y
From @nature - Inherited causes of clonal haematopoiesis in 97,691 whole genomes https://t.co/zhKdp7gbvy #bwfcams
RT @UM_Genetics: DNA sequencing tech developed in the Kitzman lab @jacobkitzman powers part of a large-scale study of somatic mutations rel…
RT @UM_Genetics: DNA sequencing tech developed in the Kitzman lab @jacobkitzman powers part of a large-scale study of somatic mutations rel…
DNA sequencing tech developed in the Kitzman lab @jacobkitzman powers part of a large-scale study of somatic mutations related to aging, cancer, and cardiovascular disease! Paper link: https://t.co/gxGyeK2nvY
所謂意義不明のクローン性造血(CHIP)は白血病のリスクやリキッドバイオプシーでのノイズとして問題になっている。10万人近いエキソームデータからCHIPを同定しその遺伝的背景に迫った論文。そのうちアフリカ系に多いTET2遺伝子変異については実験までしている。Nature誌 https://t.co/HjdjcyDgg6
Nature ハイライト:未確定の潜在能を持つクローン造血の遺伝的基盤 | Nature | Nature Research https://t.co/wP5bGMVh06
👇
Analisis de 97,691 #Genomas para estudiar las causas de la #hematopoiesis clonal y su impacto en el #cancer hematologico y #enfermedad #coronaria . #WGS #genomica Inherited causes of clonal haematopoiesis in 97,691 whole genomes https://t.co/kk2gmR06TF
Underscoring the need for diversity in studies
네이처 하이라이트:97,691명의 전장 유전체(Whole genomes)에서 클론성 조혈증(Clonal haematopoiesis)의 유전적 원인 https://t.co/FaANaQ64bZ
Nature ハイライト:未確定の潜在能を持つクローン造血の遺伝的基盤 | Nature https://t.co/7xy9BZEiCN #遺伝学 #クローン造血
RT @AlexBickMDPhD: Why do >10% of older adults have clonal blood mutations? Simultaneous germline & somatic genome analysis in ~97K pinpoi…
Kudos @AlexBickMDPhD and @pnatarajanmd !!!!! FANTASTIC work. 👏👏👏👏👏👏
RT @AuclairDan: Survey of inherited causes of clonal haematopoiesis in 97,691 whole genomes led to identification of three genetic loci ass…
RT @AuclairDan: Survey of inherited causes of clonal haematopoiesis in 97,691 whole genomes led to identification of three genetic loci ass…
RT @NatRevClinOncol: Study of 97,691 whole genomes reveals inherited causes of clonal haematopoiesis (which occurred in >4,200 individuals)…
RT @NatRevClinOncol: Study of 97,691 whole genomes reveals inherited causes of clonal haematopoiesis (which occurred in >4,200 individuals)…
Thanks for the share! @manisha_bhutani check this paper out 👇🏻
Study of 97,691 whole genomes reveals inherited causes of clonal haematopoiesis (which occurred in >4,200 individuals). Different CHIP driver genes were associated with specific blood cell, lipid and inflammatory traits: https://t.co/o1gMOH6HQd #hemeonc
Inherited causes of clonal haematopoiesis in 97,691 whole genomes. https://t.co/4dxea7xV43 https://t.co/5rEFsLAtTv
RT @AlexBickMDPhD: Why do >10% of older adults have clonal blood mutations? Simultaneous germline & somatic genome analysis in ~97K pinpoi…
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells https://t.co/jBNMASpVdQ I nherited causes of clonal haematopoiesis in 97,691 whole genomes https://t.co/SZ5lbdvXNY
RT @nature: Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specif…
RT @rosslevinemd: Great article and findings!
RT @nature: Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specif…
RT @nature: Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specif…
RT @nature: Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specif…
RT @nature: Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specif…
RT @nature: Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specif…
RT @nature: Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specif…
RT @AlexBickMDPhD: Why do >10% of older adults have clonal blood mutations? Simultaneous germline & somatic genome analysis in ~97K pinpoi…
RT @nature: Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specif…
RT @nature: Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specif…
RT @nature: Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specif…
RT @nature: Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specif…
RT @nature: Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specif…
RT @nature: Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specif…
RT @nature: Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specif…
RT @nature: Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specif…
RT @nature: Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specif…
RT @nature: Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specif…
Three genetic loci associated with clonal haematopoiesis of indeterminate potential (CHIP), one of them African ancestry-specific, are reported in a study published in Nature. https://t.co/NgjjJk9By1 https://t.co/OK8D7w3uiQ
RT @AlexBickMDPhD: Why do >10% of older adults have clonal blood mutations? Simultaneous germline & somatic genome analysis in ~97K pinpoi…
RT @pnatarajanmd: LAST AUTHOR PAPER IN @nature 🤯 (ok, breathe) https://t.co/p2BElnhXEP Check out the tag-team tweetorial below with @Alex…
RT @pnatarajanmd: LAST AUTHOR PAPER IN @nature 🤯 (ok, breathe) https://t.co/p2BElnhXEP Check out the tag-team tweetorial below with @Alex…
RT @AlexBickMDPhD: Why do >10% of older adults have clonal blood mutations? Simultaneous germline & somatic genome analysis in ~97K pinpoi…
RT @pnatarajanmd: LAST AUTHOR PAPER IN @nature 🤯 (ok, breathe) https://t.co/p2BElnhXEP Check out the tag-team tweetorial below with @Alex…
RT @AlexBickMDPhD: Why do >10% of older adults have clonal blood mutations? Simultaneous germline & somatic genome analysis in ~97K pinpoi…
Congrats to @AlexBickMDPhD on a beautiful paper identifying germline genetic contributions to risk for somatic clonal blood mutation formation
RT @pnatarajanmd: LAST AUTHOR PAPER IN @nature 🤯 (ok, breathe) https://t.co/p2BElnhXEP Check out the tag-team tweetorial below with @Alex…
RT @AlexBickMDPhD: Why do >10% of older adults have clonal blood mutations? Simultaneous germline & somatic genome analysis in ~97K pinpoi…
Super congratulations @pnatarajanmd 👏👏👏 Take a bow for your well deserved recognition!!!
RT @pnatarajanmd: LAST AUTHOR PAPER IN @nature 🤯 (ok, breathe) https://t.co/p2BElnhXEP Check out the tag-team tweetorial below with @Alex…
RT @pnatarajanmd: LAST AUTHOR PAPER IN @nature 🤯 (ok, breathe) https://t.co/p2BElnhXEP Check out the tag-team tweetorial below with @Alex…
RT @AlexBickMDPhD: Why do >10% of older adults have clonal blood mutations? Simultaneous germline & somatic genome analysis in ~97K pinpoi…