A 2015 paper in Cell (from @ElEarlyBird, @HarmitMalik et al.) tried to explain how DNA viruses quickly adapt to new species. They discovered that poxviruses gain and lose genes with ease to modify traits. (53) https://t.co/9LhBK4WOxt
@HenrikAborym And this one: https://t.co/PK9wFixOoa
RT @CeriFielding: @TheFerrariLab Vaccinia would also like to comment https://t.co/JnnbIy4UCZ
@TheFerrariLab Vaccinia would also like to comment https://t.co/JnnbIy4UCZ
@dm_depierreux @CorneliusRoemer Or duplications? https://t.co/mEE3XHQMeR
RT @TWenseleers: Note that even though poxviruses mutate slowly (being DNA viruses), they can also use gene duplication / genomic accordion…
RT @TWenseleers: @adamjkucharski But will it fizzle out? Does this lineage not have R>1 in MSM communities now? Add rapid adaptation driven…
RT @TWenseleers: Even if there would turn out to be no non-synonymous substitutions (as indicated by the Belgian seq, https://t.co/vhSJAvoI…
@DeNovo_Fatima @TRyanGregory I have virologists & also some of the phylogenomics people often seen underestimating the power of evolution. Neutral evolution often their preferred model. Most recently still with BA.4/5. And even with monkeypox rapid hos
RT @TWenseleers: Poxviruses, being DNA viruses, normally mutate slowly, but can still show rapid host adaptation through gene duplication,…
RT @TWenseleers: Poxviruses, being DNA viruses, normally mutate slowly, but can still show rapid host adaptation through gene duplication,…
RT @TWenseleers: Poxviruses, being DNA viruses, normally mutate slowly, but can still show rapid host adaptation through gene duplication,…
RT @TWenseleers: Poxviruses, being DNA viruses, normally mutate slowly, but can still show rapid host adaptation through gene duplication,…
Poxviruses, being DNA viruses, normally mutate slowly, but can still show rapid host adaptation through gene duplication, i.e. by forming "gene accordions". https://t.co/WOkc1e4RNA https://t.co/aZXTwTCFUD
DNA viruses have a lower mutation rate than RNA viruses, but there is other mechanisms by which DNA viruses can adapt to an enviroment. E.g. check out this fun science comm video and the original Cell paper by @ElEarlyBird 14/n https://t.co/mkxhWUD0G8 htt
RT @TWenseleers: @adamjkucharski But will it fizzle out? Does this lineage not have R>1 in MSM communities now? Add rapid adaptation driven…
@adamjkucharski But will it fizzle out? Does this lineage not have R>1 in MSM communities now? Add rapid adaptation driven by gene duplication or VNTRs, https://t.co/WOkc1e4RNA https://t.co/WOkc1e4RNA https://t.co/SbZDZZHD8X & get spillover to wider
RT @TWenseleers: Good news: as DNA viruses, poxviruses evolve way more slowly than RNA viruses like SARS-Cov2. Nevertheless, they can also…
RT @TWenseleers: Good news: as DNA viruses, poxviruses evolve way more slowly than RNA viruses like SARS-Cov2. Nevertheless, they can also…
RT @TWenseleers: Good news: as DNA viruses, poxviruses evolve way more slowly than RNA viruses like SARS-Cov2. Nevertheless, they can also…
RT @TWenseleers: Good news: as DNA viruses, poxviruses evolve way more slowly than RNA viruses like SARS-Cov2. Nevertheless, they can also…
RT @TWenseleers: Good news: as DNA viruses, poxviruses evolve way more slowly than RNA viruses like SARS-Cov2. Nevertheless, they can also…
RT @TWenseleers: Good news: as DNA viruses, poxviruses evolve way more slowly than RNA viruses like SARS-Cov2. Nevertheless, they can also…
RT @TWenseleers: Good news: as DNA viruses, poxviruses evolve way more slowly than RNA viruses like SARS-Cov2. Nevertheless, they can also…
Good news: as DNA viruses, poxviruses evolve way more slowly than RNA viruses like SARS-Cov2. Nevertheless, they can also show rapid adaptation via gene duplication, which in the current genome assemblies has not been looked at yet. https://t.co/WOkc1e4RNA
RT @ejustin46: @YouAreLobbyLud @C_A_Gustave @RothenburgLab @CorneliusRoemer Once again the danger has been underestimated under the false…
@YouAreLobbyLud @C_A_Gustave @RothenburgLab @CorneliusRoemer Once again the danger has been underestimated under the false pretext that poxviruses evolve slowly and may remain endemic. Yet several studies have shown their extraordinary adaptability https:
Note that even though poxviruses mutate slowly (being DNA viruses), they can also use gene duplication / genomic accordions to rapidly adapt to their host, https://t.co/WOkc1e4RNA. I understand it would require long-read sequencing at high coverage to look
Even if there would turn out to be no non-synonymous substitutions (as indicated by the Belgian seq, https://t.co/vhSJAvoI1r, but too many Ns to really conclude that), gene duplications could still be possible. But requires more sequencing to verify. https
RT @TWenseleers: @CorneliusRoemer @Giancarlo_Ali @babarlelephant @EvolveDotZoo @DarrenM98230782 @kakape Also worth noting that poxviruses c…
@CorneliusRoemer @Giancarlo_Ali @babarlelephant @EvolveDotZoo @DarrenM98230782 @kakape Also worth noting that poxviruses can deploy gene duplication / genomic accordions to rapidly adapt to their host, despite low mutation rate. This, I presume, would requ
RT @LauringLab: For those interested in poxvirus genomics, indels, terminal repeats, and what adaptation can sometimes look like, I suggest…
Poxviruses Deploy Genomic Accordions to Adapt Rapidly against Host Antiviral Defenses: Poxviruses adapt against host defenses via highly spec gene amplifictn;Gains in vaccinia fitness occur within only few serial passages in cells; https://t.co/bjh5mzzQ3U
RT @Sri_Baqri: One of my favorite Cell papers - I was a new editor in the team then and remember being 😍 😮 as the handling editor discussed…
RT @Sri_Baqri: One of my favorite Cell papers - I was a new editor in the team then and remember being 😍 😮 as the handling editor discussed…
TIL Has a similar mechanism been observed in human tumors? Certainly enough amplifications and selective pressure floating around.
RT @Sri_Baqri: One of my favorite Cell papers - I was a new editor in the team then and remember being 😍 😮 as the handling editor discussed…
Bookmarking,
@babarlelephant @JohnGal52793009 And this one: https://t.co/PK9wFixOoa
RT @Friedemann1: Never underestimate the capacity of DNA viruses to evolve. They may have lower mutation rates than RNA viruses, but there…
RT @Sri_Baqri: One of my favorite Cell papers - I was a new editor in the team then and remember being 😍 😮 as the handling editor discussed…
One of my favorite Cell papers - I was a new editor in the team then and remember being 😍 😮 as the handling editor discussed it. @HarmitMalik @ElEarlyBird
RT @Friedemann1: Never underestimate the capacity of DNA viruses to evolve. They may have lower mutation rates than RNA viruses, but there…
RT @Friedemann1: Never underestimate the capacity of DNA viruses to evolve. They may have lower mutation rates than RNA viruses, but there…
Never underestimate the capacity of DNA viruses to evolve. They may have lower mutation rates than RNA viruses, but there are other tricks. @HarmitMalik once discovered that poxviruses can rapidly increase the copy numbers of an anti-immunity gene. https:
Wow, @ElEarlyBird. I know this is almost a decade late, but this is a great read. Very straightforward, nice figures, clear science. If only these accordions could make music! https://t.co/to4nb3HINg
a cool paper on poxvirus adaptation from harmit malik's group. oldie but goodie. https://t.co/yYr4J9TP24
@russellevance Here's a few of my fav fun host-pathogen facts: 1. Pathogens have some very cool strategies to evade host immunity. For example, poxvirus 'accordions': https://t.co/BNZT9GovUY 1/3
Come il POX #Virus "accorda" il suo #genoma per eludere le difese dell'organismo. http://t.co/JRV700Ql
To the sound of its genomic 'accordion', the Vaccinia virus runs circles around hosts' defense efforts. http://t.co/wVsgC4vL
About #poxviruses... Nice abstract !!! :) http://t.co/l0prRyFM
Lovely video for this paper http://t.co/mNKMlKtt . http://t.co/ZhRXb12j
How evolutionary pressure influences viral genome make-up:See"Poxvirus Gene Accordions", http://t.co/0Kw9fkhi (movie) & http://t.co/KoQk74v0
Poxviruses have genomic accordions! Paper: http://t.co/qDvSlG1O Music video: http://t.co/FkKOEucX From Elde, Malik & others @HutchinsonCtr
Poxviruses have genomic accordions! Paper: http://t.co/qDvSlG1O Music video: http://t.co/FkKOEucX From Elde, Malik & others @HutchinsonCtr
New method of rapid DNA virus adaptation via gene expansion or "gene-accordion" mechanism discovered @CellCellPress http://t.co/7Kd947W2
Fascinating #Cell paper shows how #poxviruses duplicate immunomodulatory #genes to evade our defences. http://t.co/4OdVincn #immunity
Fascinating #Cell paper shows how #poxviruses duplicate immunomodulatory #genes to evade our defences. http://t.co/4OdVincn #immunity
Poxviruses rapidly adapt against host defences via gene amplification (via Cell) http://t.co/svnKyorm (£) #weekendreading
Poxviruses rapidly adapt against host defences via gene amplification (via Cell) http://t.co/svnKyorm (£) #weekendreading
Poxviruses Deploy Genomic Accordions to Adapt Rapidly against Host Antiviral Defenses: Nels C. Elde,... http://t.co/RLarzlwV #cell @MyEN
Congratulations to Nels Elde ( @ElEarlyBird ) on his cell paper. Be sure to watch the paper flick video. http://t.co/uuE06sQF
Congratulations to Nels Elde ( @ElEarlyBird ) on his cell paper. Be sure to watch the paper flick video. http://t.co/R7vmWRJX