Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

Overview of attention for article published in Cancer Cell, August 2020

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GSBS Therapeutics & Pharmacology Program, 14 Aug 2020

Chung et al. show that H3.3K27M mutation in DIPGs enhances glycolysis and TCA cycle metabolism to produce α-KG that is required…