RT @ejustin46: WHY ORF8 is INTERESTING ? "Among the 9 viral accessory factors, ORF8 is the largest protein interactome network of all the a…
RT @ejustin46: WHY ORF8 is INTERESTING ? "Among the 9 viral accessory factors, ORF8 is the largest protein interactome network of all the a…
RT @ejustin46: WHY ORF8 is INTERESTING ? "Among the 9 viral accessory factors, ORF8 is the largest protein interactome network of all the a…
RT @ejustin46: WHY ORF8 is INTERESTING ? "Among the 9 viral accessory factors, ORF8 is the largest protein interactome network of all the a…
RT @ejustin46: WHY ORF8 is INTERESTING ? "Among the 9 viral accessory factors, ORF8 is the largest protein interactome network of all the a…
RT @ejustin46: WHY ORF8 is INTERESTING ? "Among the 9 viral accessory factors, ORF8 is the largest protein interactome network of all the a…
Zde jsme klonovali, označili a exprimovali 26 z 29 proteinů SARS-CoV-2 v lidských buňkách a identifikovali 332 vysoce důvěryhodných protein-proteinových interakcí mezi SARS-CoV-2 a lidskými proteiny.
RT @ejustin46: WHY ORF8 is INTERESTING ? "Among the 9 viral accessory factors, ORF8 is the largest protein interactome network of all the a…
RT @BagaiDr: SARSCoV2 protein interaction map reveals targets for drug repurposing:Seq analysis SARSCoV2 isolates:30-kb genome encodes,14 (…
RT @BagaiDr: SARSCoV2 protein interaction map reveals targets for drug repurposing:Seq analysis SARSCoV2 isolates:30-kb genome encodes,14 (…
RT @BagaiDr: SARSCoV2 protein interaction map reveals targets for drug repurposing:Seq analysis SARSCoV2 isolates:30-kb genome encodes,14 (…
RT @ejustin46: WHY ORF8 is INTERESTING ? "Among the 9 viral accessory factors, ORF8 is the largest protein interactome network of all the a…
RT @ejustin46: WHY ORF8 is INTERESTING ? "Among the 9 viral accessory factors, ORF8 is the largest protein interactome network of all the a…
SARSCoV2 protein interaction map reveals targets for drug repurposing:Seq analysis SARSCoV2 isolates:30-kb genome encodes,14 (ORFs);ORF1a & ORF1ab encode polyproteins,auto-proteolytically processed into 16 (NSP1–NSP16) form replicase–transcriptase comp
RT @ejustin46: WHY ORF8 is INTERESTING ? "Among the 9 viral accessory factors, ORF8 is the largest protein interactome network of all the a…
RT @ejustin46: WHY ORF8 is INTERESTING ? "Among the 9 viral accessory factors, ORF8 is the largest protein interactome network of all the a…
RT @ejustin46: WHY ORF8 is INTERESTING ? "Among the 9 viral accessory factors, ORF8 is the largest protein interactome network of all the a…
WHY ORF8 is INTERESTING ? "Among the 9 viral accessory factors, ORF8 is the largest protein interactome network of all the accessory factors and has an array of functions which altogether antagonize host pathways to promote SARS-COV-2 pathogenesis (1) " (1
@sequencemyneuro It is conceivable although *MANY* approved drugs target sigma1 receptors with some reasonable affinity. Hydroxychlorquine is a potent sigma1 agonist and no one would recommend it for depression https://t.co/8NO9FxKdbv
RT @KeithEv84928885: Therefore, acknowledging the expertise of the partaking Institutions, one has to wonder at the real "motive" of the US…
RT @ejustin46: 8) Sources : https://t.co/2uvBeLIJiX https://t.co/8o43RROtx8 https://t.co/Y74ucuuftE
RT @ejustin46: 8) Sources : https://t.co/2uvBeLIJiX https://t.co/8o43RROtx8 https://t.co/Y74ucuuftE
@carolina_bonita This was an aha moment! Look at protein similarities! https://t.co/GuKl80yI6W
RT @ejustin46: 8) Sources : https://t.co/2uvBeLIJiX https://t.co/8o43RROtx8 https://t.co/Y74ucuuftE
RT @ejustin46: 8) Sources : https://t.co/2uvBeLIJiX https://t.co/8o43RROtx8 https://t.co/Y74ucuuftE
RT @ejustin46: 8) Sources : https://t.co/2uvBeLIJiX https://t.co/8o43RROtx8 https://t.co/Y74ucuuftE
#SARSCoV2 nucleocapsid (N) binds the stress granule (SG) proteins G3BP1/2, and to other host mRNA binding proteins including the mTOR-regulated translational repressor LARP1, the protein kinases CK2, and mRNA decay factors UPF1 and MOV10" https://t.co/INF
RT @ejustin46: 8) Sources : https://t.co/2uvBeLIJiX https://t.co/8o43RROtx8 https://t.co/Y74ucuuftE
RT @ejustin46: 8) Sources : https://t.co/2uvBeLIJiX https://t.co/8o43RROtx8 https://t.co/Y74ucuuftE
This is NOT the first paper I thought would come out of our lab! 🤷♂️ Early in the pandemic we were intrigued by studies from @KroganLab that suggested a human tRNA methyltransferase, TRMT1, might interact with the SARS-CoV-2 protease... https://t.co/2dIki
RT @KeithEv84928885: Therefore, acknowledging the expertise of the partaking Institutions, one has to wonder at the real "motive" of the US…
@mfa_russia Anatomy of the US Academia 👇
RT @KeithEv84928885: Therefore, acknowledging the expertise of the partaking Institutions, one has to wonder at the real "motive" of the US…
Therefore, acknowledging the expertise of the partaking Institutions, one has to wonder at the real "motive" of the US DOD-HHS DARPA controlled 'OWS' 👇 https://t.co/1bCbF1zik7 https://t.co/c57JwfLoTC
https://t.co/9t8SIqln6d " Notably, the sigma-1-receptor benzomorphan agonist dextromethorphan has proviral activity (Fig. 6g), further supporting the role of these receptors in viral infection."
https://t.co/asoA1xgN59 何でデキストロメトルファンだけプロウィルス活性があるんやろ
RT @WesElyMD: 5/ Worry over diabetes is NOT why a diabetes drug was tested for COVID & prevention of Long COVID. A study👇 of protein netwo…
RT @WesElyMD: 5/ Worry over diabetes is NOT why a diabetes drug was tested for COVID & prevention of Long COVID. A study👇 of protein netwo…
RT @WesElyMD: 5/ Worry over diabetes is NOT why a diabetes drug was tested for COVID & prevention of Long COVID. A study👇 of protein netwo…
RT @WesElyMD: 5/ Worry over diabetes is NOT why a diabetes drug was tested for COVID & prevention of Long COVID. A study👇 of protein netwo…
RT @WesElyMD: 5/ Worry over diabetes is NOT why a diabetes drug was tested for COVID & prevention of Long COVID. A study👇 of protein netwo…
RT @WesElyMD: 5/ Worry over diabetes is NOT why a diabetes drug was tested for COVID & prevention of Long COVID. A study👇 of protein netwo…
RT @WesElyMD: 5/ Worry over diabetes is NOT why a diabetes drug was tested for COVID & prevention of Long COVID. A study👇 of protein netwo…
RT @WesElyMD: 5/ Worry over diabetes is NOT why a diabetes drug was tested for COVID & prevention of Long COVID. A study👇 of protein netwo…
RT @WesElyMD: 5/ Worry over diabetes is NOT why a diabetes drug was tested for COVID & prevention of Long COVID. A study👇 of protein netwo…
RT @WesElyMD: 5/ Worry over diabetes is NOT why a diabetes drug was tested for COVID & prevention of Long COVID. A study👇 of protein netwo…
RT @WesElyMD: 5/ Worry over diabetes is NOT why a diabetes drug was tested for COVID & prevention of Long COVID. A study👇 of protein netwo…
RT @WesElyMD: 5/ Worry over diabetes is NOT why a diabetes drug was tested for COVID & prevention of Long COVID. A study👇 of protein netwo…
RT @WesElyMD: 5/ Worry over diabetes is NOT why a diabetes drug was tested for COVID & prevention of Long COVID. A study👇 of protein netwo…
RT @WesElyMD: 5/ Worry over diabetes is NOT why a diabetes drug was tested for COVID & prevention of Long COVID. A study👇 of protein netwo…
RT @WesElyMD: 5/ Worry over diabetes is NOT why a diabetes drug was tested for COVID & prevention of Long COVID. A study👇 of protein netwo…
5/ Worry over diabetes is NOT why a diabetes drug was tested for COVID & prevention of Long COVID. A study👇 of protein networks & 29 FDA-approved meds found metformin might help COVID & sparked COVID-OUT H/T @boulware_dr @BramanteCarolyn ht
@boulware_dr Also these two studies, the second one with human lung tissue ex vivo: https://t.co/E0DuG9SD5K https://t.co/1KSDC2ctQH
RT @nekotausagi: "we find that the widely used antitussive drug dextromethorphan has proviral activity and that therefore its use should me…
@atuntable @tony_vandongen @LDjaparidze I just googled "how many covid proteins interact with human proteins" Answer: 739 high-confidence binary and co-complex interactions Top two papers https://t.co/W3QJGhDzKu https://t.co/03FEGYwOs6
https://t.co/asoA1xgN59 デキストロメトルファンてウイルスを活性化させてまうから風邪薬を買う時はよう考えて買うのや。 ただの風邪やったらかまへんけどひょっとしてコロナやったらまずいやん。
"we find that the widely used antitussive drug dextromethorphan has proviral activity and that therefore its use should merit caution and further study in the context of the treatment of COVID-19" https://t.co/9t8SIqln6d
@LarryAllenFish1 @denisrancourt Here's a bunch of related info https://t.co/H0sADjCd31
@youngskwi @denisrancourt I wish you were right. Here, this will get you started... https://t.co/H0sADjla11
RT @keisuke4713: コロナ蛋白相互作用map→薬物転用の標的 https://t.co/U2BAsuS8BV コロナが標的とする宿主細胞蛋白の多くがmitochondriaにある→攻撃→機能不全 🦠蛋白はmitochondriaを断片化、細胞からenergy奪い…
RT @keisuke4713: コロナ蛋白相互作用map→薬物転用の標的 https://t.co/U2BAsuS8BV コロナが標的とする宿主細胞蛋白の多くがmitochondriaにある→攻撃→機能不全 🦠蛋白はmitochondriaを断片化、細胞からenergy奪い…
コロナ蛋白相互作用map→薬物転用の標的 https://t.co/U2BAsuS8BV コロナが標的とする宿主細胞蛋白の多くがmitochondriaにある→攻撃→機能不全 🦠蛋白はmitochondriaを断片化、細胞からenergy奪い、酸素感知能力を妨害 mitochondria攻撃は感染〜数h以内に開始、分裂、膜漏出(脱分極apoptosis初期) https://t.co/4n0JG15keP
Original paper: https://t.co/hvx64LbLyD Most of these interaction map studies were done in human cell lines. For those who work on #celldeath & #inflammasomes, this is a bit concerning. Why? Unlike primary cells, many cell lines lost #necroptosis #infl
@respektor The actual research: https://t.co/96ljfxE0Ad LA Times story: https://t.co/ggLYO9Wduh The gist: [see screenshot] https://t.co/EbCLdpFhdJ
@Feisty_Waters @indecision_tina A couple of news article I read about points to this study: https://t.co/yhR1fbCMEZ News article: https://t.co/Dz3ZePu66B https://t.co/U3zzDXZ0Ed
@RMedzhitov https://t.co/oGTnDsaF4m It was finally published in Nature
@_Project_Truth https://t.co/4YMJEFZ4NM found it 4 wks. go
RT @Lucie_Virevolte: 4-Using highthroughput evolutionary study of 334 SARS-CoV-2 interacting prot. (https://t.co/TTfKdwvDzs), we reveal #co…
4-Using highthroughput evolutionary study of 334 SARS-CoV-2 interacting prot. (https://t.co/TTfKdwvDzs), we reveal #common and #distinct trajectories in 🦇 and 🐒 + We identify adaptations that may shed light on modern genetic determinants of #SARSCoV2 susce
https://t.co/ydfQd7AdGY #SARSCoV2 nucleocapsid (N) binds the stress granule (SG) proteins G3BP1/2, and to other host mRNA binding proteins including the mTOR-regulated translational repressor LARP1, the protein kinases CK2, and mRNA decay factors UPF1 and
A #SARSCoV2 Protein Interaction Map Reveals Targets for Drug-Repurposing https://t.co/ydfQd7AdGY
@RolandBakerIII Seems to be a lot of disruptions with this pathogen. https://t.co/HzktVmdlck https://t.co/i9xc5Pc9SP
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing, 23Mar2020 https://t.co/aNocIvGoCR https://t.co/HzktVmdlck
RT @KekoaMDPhD: After 2 years of a COVID-free household, the disinformation war has finally arrived. My well educated RN wife is saying #de…
After 2 years of a COVID-free household, the disinformation war has finally arrived. My well educated RN wife is saying #dextromethorphan increases vital titers? Is that true? Nature 🔗https://t.co/7RaDGAu1a5 LA Times 🔗 https://t.co/grynDvY6kF CHPA 🔗 htt
1/Early 2020.. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing, 30 Apr 2020 https://t.co/aNocIvoNeh https://t.co/HzktVmuW3S
RT @CetiCov: Avril 2020, USA interactions possibles entre protéines du SARS-Cov2 emolécules existantes a montré intérêt des antihistaminiqu…
RT @CetiCov: Avril 2020, USA interactions possibles entre protéines du SARS-Cov2 emolécules existantes a montré intérêt des antihistaminiqu…
@stephenfloor Did you know "Nucleocapsid (N) of SARS-CoV-2 binds to the stress granule proteins G3BP1 and G3BP2, and to other host mRNA-binding proteins including the mTOR-regulated translational repressor LARP1"? Its fascinating. https://t.co/hKc7dXuoGl
RT @Lucie_Virevolte: 3-Using highthroughput evolutionary study of 334 SARSCoV2 interacting prot. (https://t.co/yXx1n3clqz), we reveal #dist…
3-Using highthroughput evolutionary study of 334 SARSCoV2 interacting prot. (https://t.co/yXx1n3clqz), we reveal #distinct trajectories in 🦇(CoV reservoir) &🐒🙂 + We identified adaptations that shed light on modern genetic determinants of #SARSCoV2 susc
@bilja_pop @NicolasPichot6 Je parle des effets globaux du virus qui est multifacette... https://t.co/eLK8GRO963
Par quels procédés obtient-on les spicules ? C'est ce que nous allons voir dès maintenant. La première étape consiste à chercher le segment d'ARN viral qui code pour la protéine S. https://t.co/sufQnsj0ZZ https://t.co/bjYhQmyhjo
@dianaberrent @florian_krammer Okay so that genetic marker controls interferons... https://t.co/94kxIexGNj
@Kaufhauszombie1 @BMG_Bund In Ordnung. Das mit den 60 Tagen wusste ich noch nicht. Macht aber trotzdem nichts. Bei einer Infektion ist ja das Spikeprotein des Viruses auch in meinem Körper+dem Rest vom Virus. Hier, der Unterschied einer Immunisierung durch
We applied this idea to 300+ human interactors of SARS-CoV-2 identified by Gordon et al (https://t.co/KKCZCSAUPB). We used the human STRING network, considering only edges with weight at least 700. We varied α over four orders of magnitude. (8/)
@HgoKrger1 @danielgoyal Repeating the same old rhetoric about tests. I'm not wasting my time explaining the specificity of PCR tests and viral isolation to you https://t.co/B9nA6SV7yG https://t.co/DcDBnQlHY1 & you couldn't find affinity purification?
A #SARSCoV2 Protein Interaction Map Reveals Targets for Drug-Repurposing QBI Coronavirus Research Group QCRG https://t.co/TfzSUdjGVX https://t.co/0yXrCk5FQ2 https://t.co/ydfQd7AdGY "the Sigma1 benzomorphan agonist, dextromethorphan, actually has pro-vi
RT @CetiCov: Avril 2020, USA interactions possibles entre protéines du SARS-Cov2 emolécules existantes a montré intérêt des antihistaminiqu…
@youngvintage69 Great work and kudos for looking beyond spike's immune-evasion mutants. Mutations on other viral proteins could drastically impact the interactome and viral fitness https://t.co/eAZ8rOEWyq https://t.co/oHfkkievet
@EricBillyFR La référence, sur la quercétine, que j'ai trouvée dans le fil n'est pas un essai clinique : A SARS-CoV-2 protein interaction map reveals targets for drug repurposing https://t.co/kpK9XxSbp2 De quel essai clinique parlez-vous, @EricBillyFR ?
Bonjour @GabrielServille vous avez participé à un numéro de charlatan sur ce truc moisi de l'herbe à pik.... Vous regrettez depuis ? Des excuses ? 🔽