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Michigan Publishing

Structural basis for transcriptional start site control of HIV-1 RNA fate

Overview of attention for article published in Science, April 2020
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

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mendeley
90 Mendeley
Title
Structural basis for transcriptional start site control of HIV-1 RNA fate
Published in
Science, April 2020
DOI 10.1126/science.aaz7959
Pubmed ID
Authors

Joshua D Brown, Siarhei Kharytonchyk, Issac Chaudry, Aishwarya S Iyer, Hannah Carter, Ghazal Becker, Yash Desai, Lindsay Glang, Seung H Choi, Karndeep Singh, Michael W Lopresti, Matthew Orellana, Tatiana Rodriguez, Ubiomo Oboh, Jana Hijji, Frances Grace Ghinger, Kailan Stewart, Dillion Francis, Bryce Edwards, Patrick Chen, David A Case, Alice Telesnitsky, Michael F Summers

Abstract

Heterogeneous transcriptional start site usage by HIV-1 produces 5'-capped RNAs beginning with one, two, or three 5'-guanosines (Cap1G, Cap2G, or Cap3G, respectively) that are either selected for packaging as genomes (Cap1G) or retained in cells as translatable messenger RNAs (mRNAs) (Cap2G and Cap3G). To understand how 5'-guanosine number influences fate, we probed the structures of capped HIV-1 leader RNAs by deuterium-edited nuclear magnetic resonance. The Cap1G transcript adopts a dimeric multihairpin structure that sequesters the cap, inhibits interactions with eukaryotic translation initiation factor 4E, and resists decapping. The Cap2G and Cap3G transcripts adopt an alternate structure with an elongated central helix, exposed splice donor residues, and an accessible cap. Extensive remodeling, achieved at the energetic cost of a G-C base pair, explains how a single 5'-guanosine modifies the function of a ~9-kilobase HIV-1 transcript.

X Demographics

X Demographics

The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 90 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 33%
Researcher 13 14%
Student > Doctoral Student 7 8%
Other 4 4%
Student > Postgraduate 3 3%
Other 7 8%
Unknown 26 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 38 42%
Immunology and Microbiology 7 8%
Agricultural and Biological Sciences 5 6%
Chemistry 3 3%
Medicine and Dentistry 3 3%
Other 7 8%
Unknown 27 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 90. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 March 2021.
All research outputs
#478,183
of 25,571,620 outputs
Outputs from Science
#11,633
of 83,117 outputs
Outputs of similar age
#14,853
of 406,346 outputs
Outputs of similar age from Science
#332
of 976 outputs
Altmetric has tracked 25,571,620 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,117 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 406,346 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 976 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.