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Structural basis for transcriptional start site control of HIV-1 RNA fate

Overview of attention for article published in Science, April 2020
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)
Title
Structural basis for transcriptional start site control of HIV-1 RNA fate
Published in
Science, April 2020
DOI 10.1126/science.aaz7959
Pubmed ID
Authors

Joshua D. Brown, Siarhei Kharytonchyk, Issac Chaudry, Aishwarya S. Iyer, Hannah Carter, Ghazal Becker, Yash Desai, Lindsay Glang, Seung H. Choi, Karndeep Singh, Michael W. Lopresti, Matthew Orellana, Tatiana Rodriguez, Ubiomo Oboh, Jana Hijji, Frances Grace Ghinger, Kailan Stewart, Dillion Francis, Bryce Edwards, Patrick Chen, David A. Case, Alice Telesnitsky, Michael F. Summers, Brown, Joshua D, Kharytonchyk, Siarhei, Chaudry, Issac, Iyer, Aishwarya S, Carter, Hannah, Becker, Ghazal, Desai, Yash, Glang, Lindsay, Choi, Seung H, Singh, Karndeep, Lopresti, Michael W, Orellana, Matthew, Rodriguez, Tatiana, Oboh, Ubiomo, Hijji, Jana, Ghinger, Frances Grace, Stewart, Kailan, Francis, Dillion, Edwards, Bryce, Chen, Patrick, Case, David A, Telesnitsky, Alice, Summers, Michael F

Abstract

Heterogeneous transcriptional start site usage by HIV-1 produces 5'-capped RNAs beginning with one, two, or three 5'-guanosines (Cap1G, Cap2G, or Cap3G, respectively) that are either selected for packaging as genomes (Cap1G) or retained in cells as translatable messenger RNAs (mRNAs) (Cap2G and Cap3G). To understand how 5'-guanosine number influences fate, we probed the structures of capped HIV-1 leader RNAs by deuterium-edited nuclear magnetic resonance. The Cap1G transcript adopts a dimeric multihairpin structure that sequesters the cap, inhibits interactions with eukaryotic translation initiation factor 4E, and resists decapping. The Cap2G and Cap3G transcripts adopt an alternate structure with an elongated central helix, exposed splice donor residues, and an accessible cap. Extensive remodeling, achieved at the energetic cost of a G-C base pair, explains how a single 5'-guanosine modifies the function of a ~9-kilobase HIV-1 transcript.

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Attention Score in Context

This research output has an Altmetric Attention Score of 98. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2020.
All research outputs
#201,883
of 15,142,754 outputs
Outputs from Science
#6,914
of 65,840 outputs
Outputs of similar age
#7,109
of 225,112 outputs
Outputs of similar age from Science
#227
of 825 outputs
Altmetric has tracked 15,142,754 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 65,840 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 49.2. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 225,112 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 825 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.