A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis. https://t.co/HqyzzjBJ3n
#UMPrecisionHealth Investigator Peter Todd, MD, PhD, led a study on genetic repeats, protein synthesis, and fragile X-associated disorders that was published in @NatureNeuro. The research was recently featured in a @umichmedicine lab report https://t.co/g
The anti-sense oligonucleotide blockade of CGG RAN enhances the regulation of endogenous FMRP expression demonstrate the therapeutic potential of modulating CGG RAN translation in Fragile X Syndrome https://t.co/mwvCpqpIFh
A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis https://t.co/uCwelDmVsH https://t.co/9KaUA2Qt7h
Great work on the physiological role of RAN translation in learning and memory.
“We keep discovering new repeat diseases all the time,” P Todd, @UMneurosciences in @BioWorldMedTech and @NatureNeuro https://t.co/gu0ZNYPL0A https://t.co/YkVkAWXc98
A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis $IONS $AKCA $WVE $PRQR $BPTH $NBSE $RHHBY $GLAXO $AZN $XCUR #antisense @jwattsgroup @HastingsLab @Mendell_lab @isa_aznarez @oligogirl @lab_zhou @Jandritu htt
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
exciting elucidation of a native function for RAN translation and CGG repeats in fragile X protein (FMRP).
RT @NatureNeuro: The synthesis of Fragile X protein (FMRP) is regulated by repeat-associated non-AUG-initiated translation of expanded CGG…
RT @mariahhoye: Great read on a physiological context for RAN translation in regulating levels of FMRP! Also love that this work reinforces…
RT @NatureNeuro: The synthesis of Fragile X protein (FMRP) is regulated by repeat-associated non-AUG-initiated translation of expanded CGG…
RT @NatureNeuro: The synthesis of Fragile X protein (FMRP) is regulated by repeat-associated non-AUG-initiated translation of expanded CGG…
RT @NatureNeuro: The synthesis of Fragile X protein (FMRP) is regulated by repeat-associated non-AUG-initiated translation of expanded CGG…
RT @NatureNeuro: The synthesis of Fragile X protein (FMRP) is regulated by repeat-associated non-AUG-initiated translation of expanded CGG…
RT @NatureNeuro: The synthesis of Fragile X protein (FMRP) is regulated by repeat-associated non-AUG-initiated translation of expanded CGG…
RT @NatureNeuro: The synthesis of Fragile X protein (FMRP) is regulated by repeat-associated non-AUG-initiated translation of expanded CGG…
The synthesis of Fragile X protein (FMRP) is regulated by repeat-associated non-AUG-initiated translation of expanded CGG repeats (CGG RAN); antisense oligonucleotides (ASOs) that block this suppress repeat toxicity and prolong survival in neurons https://
2⃣4⃣ RAN translation of FMRP CGG repeats acts as a 'break' to FMRP expression. Blocking translation initiation at non-AUG sites using ASOs prevents RAN translation, derepresses FMRP expression in diseased neurons, and improves neuronal survival https://t.
Great read on a physiological context for RAN translation in regulating levels of FMRP! Also love that this work reinforces there is a lot of basic biology that we can learn from the disease state! Uncover fascinating biology and combat disease?! #WINWIN
RT @recherche_anima: #fragileX🧠 syndrome: a study #invitro🧫 on human cells and #invivo in a # mouse🐁 model showed how the modification of t…
#fragileX🧠 syndrome: a study #invitro🧫 on human cells and #invivo in a # mouse🐁 model showed how the modification of the FMR #gene🧬 causes a neurotoxic effect and suggested a therapeutic pathway: modulating CGG-RAN activity 😮 🤔 https://t.co/5Q7pNe66q9 htt
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @recherche_anima: Syndrome #Xfragile🧠: une étude #invitro🧫 sur cellules humaines et #invivo sur modèle #souris🐁 tente de comprendre comm…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @TweetALSMND: Could understanding the "native" role of #RANtranslation in neurons hold the key to identifying targets of neurological di…
Repeat-associated non-AUG-initiated translation of expanded CGG repeats (CGG RAN) from the FMR1 5′-leader produces ... FMR1遺伝子5’端リーダー領域CGG反復配列伸長の開始コドン(AUG)以外からの翻訳・RAN翻訳は脆弱X症候群 (FXS) の神経変性に寄与する有毒蛋白質を作る https://t.co/wiI3U0SFnY
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @recherche_anima: Syndrome #Xfragile🧠: une étude #invitro🧫 sur cellules humaines et #invivo sur modèle #souris🐁 tente de comprendre comm…
RT @recherche_anima: Syndrome #Xfragile🧠: une étude #invitro🧫 sur cellules humaines et #invivo sur modèle #souris🐁 tente de comprendre comm…
Syndrome #Xfragile🧠: une étude #invitro🧫 sur cellules humaines et #invivo sur modèle #souris🐁 tente de comprendre comment la modification du #gène🧬 FMR entraîne un effet neurotoxique et propose une voie thérapeutique: moduler l'activité CGG-RAN 😮🤔 https://
Interesting new study about how RAN translation happens in normal contexts in neurons similar to uORFs, and isn’t just observed in disease:
RT @RigoRnaIt: Check out our paper in collaboration with the Todd lab on using ASOs to up-regulate FMR1 as a therapeutic strategy for fragi…
RT @RigoRnaIt: Check out our paper in collaboration with the Todd lab on using ASOs to up-regulate FMR1 as a therapeutic strategy for fragi…
RT @TweetALSMND: Could understanding the "native" role of #RANtranslation in neurons hold the key to identifying targets of neurological di…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
blocking #ASOs suppressed repeat toxicity and prolonged survival of human and rodent neurons. Congrats.
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @RigoRnaIt: Check out our paper in collaboration with the Todd lab on using ASOs to up-regulate FMR1 as a therapeutic strategy for fragi…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @RigoRnaIt: Check out our paper in collaboration with the Todd lab on using ASOs to up-regulate FMR1 as a therapeutic strategy for fragi…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @RigoRnaIt: Check out our paper in collaboration with the Todd lab on using ASOs to up-regulate FMR1 as a therapeutic strategy for fragi…
Check out our paper in collaboration with the Todd lab on using ASOs to up-regulate FMR1 as a therapeutic strategy for fragile X-associated disorders. https://t.co/QEWlutArLq
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis https://t.co/R7S2EkHE4g
RT @TweetALSMND: Could understanding the "native" role of #RANtranslation in neurons hold the key to identifying targets of neurological di…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
Fantastic news and a really important set of findings, Peter. Congrats!
Shannon, this is an important study shedding light on repeat biology in the nervous system. Kudos to you, Peter Todd and the rest of your team!
https://t.co/Kvo8K7QH25 this is cool--using ASOs to block translation of expanded CGG repeats,enhancing endogenous FMRP expression in human neurons #genetics #fragilex #PrecisionMedicine #sciencetwitter #RNA
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @ShorterLab: A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis: https://t.co/vbs6Y8S5Xs
Wow, strong piece of work @realToddLab!
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @ShorterLabGroup: A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis - new work from @realT…
RT @realToddLab: I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats…
RT @ShorterLabGroup: A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis - new work from @realT…
I am thrilled to share our new work published today @NatureNeuro on a native function for RAN translation and CGG repeats in regulating neuronal protein translation. This represents ~5 years of work so will give a quick summary over a few tweets 1/ https:
RT @ShorterLab: A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis: https://t.co/vbs6Y8S5Xs
A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis https://t.co/g0YubtLFxC https://t.co/OS5g4Xjg8w
RT @KatelynMGreen: Congrats @shannonwrightUM, Caitlin Rodriguez, and all other authors on the latest @realToddLab publication in Nat Neuro!…
RT @KatelynMGreen: Congrats @shannonwrightUM, Caitlin Rodriguez, and all other authors on the latest @realToddLab publication in Nat Neuro!…
@shannonwrightUM the first of many to come 😃
Congrats @shannonwrightUM, Caitlin Rodriguez, and all other authors on the latest @realToddLab publication in Nat Neuro!
Way to go, @shannonwrightUM and team!!
Congrats to Getzler lab alum @shannonwrightUM on this co-1st author @NatureNeuro paper! This kind of molecular neuroscience flows naturally from her hard work as neuroscience/biochem double major (!!) @KenyonCollege. It's such a joy to see you thriving! h
A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis - Nature Neuroscience via BrainSights for iOS https://t.co/agFrOrv39o
A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis: https://t.co/vbs6Y8S5Xs
A native function for RAN translation and CGG repeats in regulating fragile X protein synthesis - new work from @realToddLab https://t.co/GMehj02E7P
Could understanding the "native" role of #RANtranslation in neurons hold the key to identifying targets of neurological disease? A new study @realToddLab opens up the possibility https://t.co/orkTKQd8cu #FraX #C9orf72 https://t.co/Jkeb7zE1mN