@DrIramHussain @NEJM 1/2 "This observation may reflect differences between the use of vitamin D for prevention in previous studies and the use of vitamin D as treatment during acute illness in the present trial, but it also may be the result of chance". h
RT @T_Fiolet: DO-HEALTH trial : https://t.co/wTr2Hsioil D2D Trial : https://t.co/2kFOGTNTk2 MDIG trial: https://t.co/YQlhljt8o7 VIOLET Tria…
DO-HEALTH trial : https://t.co/wTr2Hsioil D2D Trial : https://t.co/2kFOGTNTk2 MDIG trial: https://t.co/YQlhljt8o7 VIOLET Trial : https://t.co/EG3MYdCdo1 Mongolie: https://t.co/YbtDBX2d8d https://t.co/1H7QaDs5bB. EVITA : https://t.co/mDq7ROwEhj FIND https:/
RT @AaronGoodman33: Vitamin D to critically ill patients in ICU didn't make things better https://t.co/oBmMUvXdsB
RT @AaronGoodman33: Vitamin D to critically ill patients in ICU didn't make things better https://t.co/oBmMUvXdsB
Vitamin D to critically ill patients in ICU didn't make things better https://t.co/oBmMUvXdsB
@Woodynist @Vivet_Lili Pour le "à risque" venant au long court: https://t.co/6oa4AOo28t https://t.co/Ev6VLaPyp3 Pour le patient critique tout venant: https://t.co/8cginJ3coH Dans la covid: https://t.co/UxUQQCnxpU Reste l'hypothèse d'impact modéré très t
RT @pulp_nutrition: VIOLET trial - large RCT, 1059 vit D-deficient pts, critical illness - No sig diff in 90d all-cause mortality / other…
VIOLET trial - large RCT, 1059 vit D-deficient pts, critical illness - No sig diff in 90d all-cause mortality / other non-fatal outcomes ** intervention was single loading dose vit D3 -> ?? not physiological (doesn't mean it doesn't work) https://t
@FlightDocKosuke 個別の研究結果を見ると、 小規模RCTで有効性が示唆され、 大規模RCTで死亡率に差がない というパターンで、個人的には他のビタミンと同様の結果に落ち着く可能性が高いと予想しています。 🔗https://t.co/E2oEnXH38b
RT @ACLakeMD: When are we going to accept that low vitamin D is just ASSOCIATED with disease, very rarely the CAUSE of disease. If you neve…
RT @nickmmark: Similarly, many studies found that vitamin D levels are low in sepsis & that lower VitD levels are associated w/ worse outco…
Similarly, many studies found that vitamin D levels are low in sepsis & that lower VitD levels are associated w/ worse outcomes. And Yet, when the #PETALstudy was performed it found numerically HIGHER mortality (23.5% vs 20.6%) w/ VitD supplementation
#6 - ENSAIO CLÍNICO RANDOMIZADO Deficiência de vitamina D está associada a piores desfechos em pacientes críticos, mas será que corrigir essa deficiência com uma única megadose via enteral (540.000 UI) é capaz de gerar melhores desfechos clínicos? https:
@ScottAdamsSays VIT D levels correlate with everything and nothing at the same time. https://t.co/02kX0K6D9c https://t.co/JamZmlmpeA
@CoffeeTwitting It’s not necessarily spurious. It’s been studied before in other diseases & didn’t improve mortality. For example critical illness (https://t.co/u9JDZMb5YQ) & sepsis (https://t.co/W4F7hxPaKb) Not saying it won’t work but low VitD i
@GreedyHuat @leehsienloong What’s the point of test kits. How about some Vitamins C, D and Zinc for the elderly? https://t.co/m4yleSnZMI
RT @AnesthRea: Early High-Dose Vitamin D3 for Critically Ill, Vitamin D–Deficient Patients #NEJM https://t.co/gyJUJ0H3KO
@DanOfAmerica @KoolLove2643 @barttels2 @MccabeCJM @Jusrangers It will not do anything meaningful but go ahead - just don't sell it as a cure. We have been trying vitamin F in critical illness for like ever - placrbo per PETAL https://t.co/i026UAj8L9
#SASPEN_Education: Early High-Dose Vitamin D3 for Critically Ill, Vitamin D-Deficient Patients. https://t.co/e91v0CVopW
“I don’t think gut microbiome tx would be beneficial in high acuity Covid patients.” “This study says it is...” *links study on Vit D deficiency* “I’m sorry, what is this?” #bringscienceeducationback #makeamericathinkagain #MedEd #readthewholethingnottheti
@CaityNeill @WesElyMD This study [see link] appears to indicate otherwise: https://t.co/GnXX0BYNSl
@DerekSloanCPC "Vitamin D may improve outcomes in critically ill patients. Preclinical data suggest that vitamin D is a potent immunomodulatory agent that is essential for lung development and function." https://t.co/uUidhd5RIY
"Vitamin D may improve outcomes in critically ill patients. Preclinical data suggest that vitamin D is a potent immunomodulatory agent that is essential for lung development and function." https://t.co/uUidhd5RIY
@TrueNorthCentre "Vitamin D may improve outcomes in critically ill patients. Preclinical data suggest that vitamin D is a potent immunomodulatory agent that is essential for lung development and function." https://t.co/uUidhd5RIY
@georgedarroch Not specifically, I found these, but might be more appropriate to look only at infections and maybe longer supplementation pre-period? As the effect is most likely modest, it would require large studies https://t.co/0xqygce95x https://t.co/
14/17 Un RCT chez des patients déficitaires, dans les 12 h de l’admission en soins intensifs (540 000 UI en dose unique) n’a pas diminué la mortalité à 90 jours. Dans d’autres études, la vit D n’a pas eu d’effet sur l’évolution de la tuberculose. https://t
@jneill @SwaledaleMutton @avaltd @GrumpyOldDoc Perhaps it depends on how ill you are to start with and how much you are given? https://t.co/3ZyuM6VXwE https://t.co/sAdGdO8kfi
@EdQian @MattStier_PSTP Agreed. Didn't we (#CriticalCare #MedTwitter collectively, that it) literally just have a vitamin D in critical illness discussion, like a year ago? Short memories ➡️ suspiciously optimistic priors. https://t.co/jAtV2Kxe55
RT @Mymblemum: @SwaledaleMutton @avaltd @GrumpyOldDoc @jneill Possibly here? https://t.co/lxGmwWazEH
@SwaledaleMutton @avaltd @GrumpyOldDoc @jneill Possibly here? https://t.co/lxGmwWazEH
@KCKlatt In acute illness, it has already been shown that not correcting severe vitamin D deficiency doesn't harm. Nothing ethically wrong with this trial. https://t.co/ClPXInTlLe
@jsnrcarr @phlegmfighter also worth noting 91% exclusion is high but not very uncommon in crit care trials (some of the trialists here on twitter can discuss more in-depth than i can). for example, violet had similar numbers. https://t.co/DESBRj2TIz
@Skeptoidius @__lue___ Independientemente de eso, es alguien que destaca los estudios favorables (como ese que citas con n=36) y se olvida de otros sin resultados, como este con n>1000: https://t.co/QlEHoXeN2W
@79ka2011 It is right! However, the thread also shows the results of the VIOLET trial-2019-published in NEJM, where mortality did not decrease at 90 days nor was a subgroup of patients identified with a possible benefit https://t.co/KOfrj786Tm
RT @FabioTorressav: @CamiloPrietoVal @vlasoscuro El ultimo ensayo reciente del 2019 (VIOLET trial) cuyo objetivo primario si fue mortalidad…
@CamiloPrietoVal @vlasoscuro El ultimo ensayo reciente del 2019 (VIOLET trial) cuyo objetivo primario si fue mortalidad a 90 dias tampoco resulto positivo para la suplementacion de VitD y concluyen lo siguiente: https://t.co/viROCxQg5N https://t.co/DvH23
Bon ça c’est fait. Next?? Early administration of high-dose enteral vitamin D3 did not provide an advantage over placebo with respect to 90-day mortality or other, nonfatal outcomes among critically ill, vitamin D–deficient patients.
RT @QuackFighter: #hatersgonnahate Early High-Dose Vitamin D3 for Critically Ill, Vitamin D–Deficient Patients | NEJM https://t.co/ZZr6kFj…
RT @QuackFighter: #hatersgonnahate Early High-Dose Vitamin D3 for Critically Ill, Vitamin D–Deficient Patients | NEJM https://t.co/ZZr6kFj…
Early High-Dose Vitamin D3 for Critically Ill, Vitamin D–Deficient Patients | NEJM https://t.co/wuxjZh8StD
Bon ça c’est fait !!! Bah non hein ça marche pas 🙄🙄
RT @jdflaysakier: Et badaboum ! La vitamine D as hautes doses chez des patients graves ça ne donne rien
RT @jdflaysakier: Et badaboum ! La vitamine D as hautes doses chez des patients graves ça ne donne rien https://t.co/fIKRXnqSGG
RT @jdflaysakier: Et badaboum ! La vitamine D as hautes doses chez des patients graves ça ne donne rien
RT @jdflaysakier: Et badaboum ! La vitamine D as hautes doses chez des patients graves ça ne donne rien
RT @jdflaysakier: Et badaboum ! La vitamine D as hautes doses chez des patients graves ça ne donne rien https://t.co/fIKRXnqSGG
RT @jdflaysakier: Et badaboum ! La vitamine D as hautes doses chez des patients graves ça ne donne rien
RT @jdflaysakier: Et badaboum ! La vitamine D as hautes doses chez des patients graves ça ne donne rien https://t.co/fIKRXnqSGG
RT @QuackFighter: #hatersgonnahate Early High-Dose Vitamin D3 for Critically Ill, Vitamin D–Deficient Patients | NEJM https://t.co/ZZr6kFj…
Et badaboum ! La vitamine D as hautes doses chez des patients graves ça ne donne rien
@NICEComms @PHE_uk This one used a single dose of very high Vit D and then expected a result. Instead, other trials have given Vit D at high levels as a course of supplemental treatment. Why would one dose be expected to achieve amelioration? https://t.co/
@endpop @WeeklyRich @PeterHotez Gotta be carefully abt vit d. Agree that it’s low risk but it has a track record of looking great in observational studies but failing in big, well done RCTs. I think it’s a major stretch to think it will work https://t.co/I
"Early administration high-dose 540 000 IU #vitaminD3 didn't provide an advantage over placebo with respect to 90-day mortality or other outcomes among critically ill, vitamin D–deficient patients" Any relevance to #COVID19 critically ill? @NEJM https://
RT @rafabravo: La administración temprana de vitamina D3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a…
RT @rafabravo: La administración temprana de vitamina D3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a…
RT @cpontesg: ⚠️Early high-dose Vitamin D3 for critically Ill, Vit D–deficient patients did not improve 90-day mortality or other nonfatal…
RT @cpontesg: ⚠️Early high-dose Vitamin D3 for critically Ill, Vit D–deficient patients did not improve 90-day mortality or other nonfatal…
RT @cpontesg: ⚠️Early high-dose Vitamin D3 for critically Ill, Vit D–deficient patients did not improve 90-day mortality or other nonfatal…
RT @cpontesg: ⚠️Early high-dose Vitamin D3 for critically Ill, Vit D–deficient patients did not improve 90-day mortality or other nonfatal…
RT @cpontesg: ⚠️Early high-dose Vitamin D3 for critically Ill, Vit D–deficient patients did not improve 90-day mortality or other nonfatal…
RT @cpontesg: ⚠️Early high-dose Vitamin D3 for critically Ill, Vit D–deficient patients did not improve 90-day mortality or other nonfatal…
RT @cpontesg: ⚠️Early high-dose Vitamin D3 for critically Ill, Vit D–deficient patients did not improve 90-day mortality or other nonfatal…
La evidencia es lo q tiene
RT @cpontesg: ⚠️Early high-dose Vitamin D3 for critically Ill, Vit D–deficient patients did not improve 90-day mortality or other nonfatal…
RT @cpontesg: ⚠️Early high-dose Vitamin D3 for critically Ill, Vit D–deficient patients did not improve 90-day mortality or other nonfatal…
⚠️Early high-dose Vitamin D3 for critically Ill, Vit D–deficient patients did not improve 90-day mortality or other nonfatal outcomes in a double-blind pcb controlled trial stopped x futility. Mortality & ARDS point estimates ➡️ higher in VD3 group.
La administración temprana de vitamina D 3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a la mortalidad a los 90 días u otros resultados no fatales entre los pacientes críticamente enfermos con deficiencia de vitamina D h
¿Pero realmente sabemos cuáles son los niveles "normales" de Vit D?
RT @rafabravo: La administración temprana de vitamina D3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a…
RT @quequesierra: Gracias Rafa. Muy interesante. Pacientes con deficiencia, resuelta en el grupo intervención sin resultado alguno. Pacient…
RT @rafabravo: La administración temprana de vitamina D3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a…
RT @rafabravo: La administración temprana de vitamina D3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a…
RT @rafabravo: La administración temprana de vitamina D3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a…
RT @rafabravo: La administración temprana de vitamina D3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a…
RT @desselebrada: pero la junta de Andalucía sabe más que todo eso https://t.co/SBPGKmXrav
RT @rafabravo: La administración temprana de vitamina D3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a…
RT @rafabravo: La administración temprana de vitamina D3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a…
RT @rafabravo: La administración temprana de vitamina D3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a…
RT @rafabravo: La administración temprana de vitamina D3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a…
RT @IanMedical: No sirve ni para el déficit de vitamina D. No sé, fíjate...
RT @joseangelcano94: Para todos los que os estáis volviendo locos con la vitamina D
RT @rafabravo: La administración temprana de vitamina D3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a…
RT @rafabravo: La administración temprana de vitamina D3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a…
RT @Mylestring: Y punto. https://t.co/zu4g7q6WRw
RT @Mylestring: Y punto. https://t.co/zu4g7q6WRw
RT @desselebrada: pero la junta de Andalucía sabe más que todo eso
RT @desselebrada: pero la junta de Andalucía sabe más que todo eso https://t.co/SBPGKmXrav
RT @Mylestring: Y punto.
RT @rafabravo: La administración temprana de vitamina D3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a…
Para todos los que os estáis volviendo locos con la vitamina D
RT @rafabravo: La administración temprana de vitamina D3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a…
RT @rafabravo: La administración temprana de vitamina D3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a…
RT @Mylestring: Y punto.
Y punto.
No sirve ni para el déficit de vitamina D. No sé, fíjate...
pero la junta de Andalucía sabe más que todo eso
RT @rafabravo: La administración temprana de vitamina D3 enteral en dosis altas no proporcionó una ventaja sobre el placebo con respecto a…