Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair https://t.co/FIzQq0uolw
RT @arta_semita: https://t.co/zTIZZ9w8rU "Itaconate is an immunometabolite with both anti-inflammatory and bactericidal effects. Its coenz…
https://t.co/zTIZZ9w8rU "Itaconate is an immunometabolite with both anti-inflammatory and bactericidal effects. Its coenzyme A (CoA) derivative, itaconyl-CoA, inhibits B12-dependent methylmalonyl-CoA mutase (MCM) by an unknown mechanism."
RT @uranus_2: suicide inactivator of humanってこれじゃまるでヒトの自殺を抑制する作用があるみたいに感じる。Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase…
suicide inactivator of humanってこれじゃまるでヒトの自殺を抑制する作用があるみたいに感じる。Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair https://t.co/Zngp5vZNkG
RT @_abew_: Mtb-infected macrophages produce itaconyl-CoA which acts as a suicide inhibitor targeting Mtb methylmalonyl-CoA mutase, an impo…
RT @_abew_: Mtb-infected macrophages produce itaconyl-CoA which acts as a suicide inhibitor targeting Mtb methylmalonyl-CoA mutase, an impo…
RT @_abew_: Mtb-infected macrophages produce itaconyl-CoA which acts as a suicide inhibitor targeting Mtb methylmalonyl-CoA mutase, an impo…
RT @_abew_: Mtb-infected macrophages produce itaconyl-CoA which acts as a suicide inhibitor targeting Mtb methylmalonyl-CoA mutase, an impo…
【今週のScience】 イタコニルCoAはメチルマロニルCoAムターゼに安定的なビラジカルを形成し活性と修復を阻害する https://t.co/BlhkTw03Ro #今週のScience #サイエンス誌 #AAAS #翻訳
RT @CarolynBertozzi: Wow, fascinating work https://t.co/7oX8Ic8a7n
RT @_abew_: Mtb-infected macrophages produce itaconyl-CoA which acts as a suicide inhibitor targeting Mtb methylmalonyl-CoA mutase, an impo…
Wow, fascinating work
Mtb-infected macrophages produce itaconyl-CoA which acts as a suicide inhibitor targeting Mtb methylmalonyl-CoA mutase, an important enzyme in propionate metabolism. Nature never ceases to impress with the small molecules it uses to inhibit enzymes. http
RT @FrezzaLab: Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair https://t.co/3Vnj6Okdv0
RT @FrezzaLab: Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair https://t.co/3Vnj6Okdv0
Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair https://t.co/3Vnj6Okdv0
RT @markus_ruetz: My first Science paper! 😀 My favorite buddies vitamin B12 and radicals Itaconyl-CoA forms a stable biradical in methylm…
RT @markus_ruetz: My first Science paper! 😀 My favorite buddies vitamin B12 and radicals Itaconyl-CoA forms a stable biradical in methylm…
RT @markus_ruetz: My first Science paper! 😀 My favorite buddies vitamin B12 and radicals Itaconyl-CoA forms a stable biradical in methylm…
RT @BehavEcolPapers: Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair https://t.co/58P…
Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair. https://t.co/h9NZpXetxD
Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair. https://t.co/mshnglQ1Dm
Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair https://t.co/fv2iAaCJ47
RT @ImmunoEditor: Now in @sciencemagazine: work by @markus_ruetz, R. Banerjee, & colleagues (@UMich) shows that #itaconate derivative coenz…
RT @erlesen: 1.8 billion ppl are infected with Mycobacterium tuberculosis Mtb, the common and occasionally deadly bacterium that causes mil…
1.8 billion ppl are infected with Mycobacterium tuberculosis Mtb, the common and occasionally deadly bacterium that causes millions of cases of tuberculosis each year https://t.co/JcljkG3iat Immune system targets vitamin B12 pathway to neutralize bacteria!
RT @MichiganChem: Congrats to Markos Koutmos who co-authored in this issue of @sciencemagazine! Congrats to him and our colleague in Biol…
Now in @sciencemagazine: work by @markus_ruetz, R. Banerjee, & colleagues (@UMich) shows that #itaconate derivative coenzyme A disrupts the M. #tuberculosis enzymatic machinery! https://t.co/cjBdOAGxFf w/ a Perspective by A. Boal: https://t.co/hdns
RT @MichiganChem: Congrats to Markos Koutmos who co-authored in this issue of @sciencemagazine! Congrats to him and our colleague in Biol…
Huge congrats to @markus_ruetz and the Koutmos and Banerjee groups! Big things happening at UM!
RT @MichiganChem: Congrats to Markos Koutmos who co-authored in this issue of @sciencemagazine! Congrats to him and our colleague in Biol…
RT @MichiganChem: Congrats to Markos Koutmos who co-authored in this issue of @sciencemagazine! Congrats to him and our colleague in Biol…
RT @nchembio: A new paper in yesterday’s @sciencemagazine by Ruma Banerjee’s group identified itaconyl-CoA as a suicide inactivator of meth…
Congrats to Markos Koutmos who co-authored in this issue of @sciencemagazine! Congrats to him and our colleague in Biological Chemistry, Ruma Bannerjee, on this publication. Check it out here: https://t.co/JQXjf9JQ3x #nationalauthorsday #science #Mic
Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair https://t.co/58P3CbaOni @Sciencemagazine
RT @nchembio: A new paper in yesterday’s @sciencemagazine by Ruma Banerjee’s group identified itaconyl-CoA as a suicide inactivator of meth…
A new paper in yesterday’s @sciencemagazine by Ruma Banerjee’s group identified itaconyl-CoA as a suicide inactivator of methylmalonyl-CoA mutase by forming a biradical adduct with the B12 coenzyme. https://t.co/AOaEUNLmpE
Latest work from the Banerjee Lab! The #immune system mimics a #pathogen! Our paper on how #itaconate is used to derail a #radical #B12 #metalloenzyme-just out in #Science-and the accompanying perspective by Amy Boal. https://t.co/blbyilOvlo
RT @AJPierik: https://t.co/DACPT4zy6k Congrats Ruma and all others, great stuff, long live B12!
https://t.co/DACPT4zy6k Congrats Ruma and all others, great stuff, long live B12!
My first Science paper! 😀 My favorite buddies vitamin B12 and radicals Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair https://t.co/NKvKnGshYT
Another prospective MOA for itaconate
RT @PoojaJha2015: 𝗥𝘂𝗺𝗮 𝗕𝗮𝗻𝗲𝗿𝗷𝗲𝗲 & colleagues describe how #immunometabolite #itaconate inhibits #propionate metabolism, a crucial metabolic…
𝗥𝘂𝗺𝗮 𝗕𝗮𝗻𝗲𝗿𝗷𝗲𝗲 & colleagues describe how #immunometabolite #itaconate inhibits #propionate metabolism, a crucial metabolic pathway in pathogenic Mycobacterium #tuberculosis (Mtb).@sciencemagazine @umichmedicine https://t.co/8PpvLGr929