17a) Perspective of the #genetic expert: consider that genome-wide studies comparing #diabetes +/- #DKD or other comparisons revealed genetic #CKD RF unrelated to #diabetes, e.g., 👉#Alport-like COL4 gene variants (=GBM weakness; see 🔓https://t.co/YfFkbDny

RT @ckd_ce: 17a) Perspective of the #genetic expert: consider that genome-wide studies comparing #diabetes +/- #DKD or other comparisons re…

17a) Perspective of the #genetic expert: consider that genome-wide studies comparing #diabetes +/- #DKD or other comparisons revealed genetic #CKD RF unrelated to #diabetes, e.g., 👉#Alport-like COL4 gene variants (=GBM weakness; see 🔓https://t.co/YfFkbDny

A metaGWAS of T1D published in @JASN_News in 2019 revealed 16 new diabetic kidney disease–associated loci at genome-wide significance. https://t.co/9zyeOtnn6C The very top variant was in COL4A3, a missense variant that confers protection from DKD (OR 0.7

RT @NatRevNeph: New New & Views! @JeffMinerPhD discusses a GWAS study that identified an association between a COL4A3 variant and risk of D…

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen | American Society of Nephrology https://t.co/mInj1sxfIp

Here is the study who described this: Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen https://t.co/9qHXQ1Jy9N

Hematuria? Proteinuria? Hmmm 🤔 brings this recent paper in #T1DM https://t.co/XXklL2XdQB

RT @NatRevNeph: New New & Views! @JeffMinerPhD discusses a GWAS study that identified an association between a COL4A3 variant and risk of D…

RT @NatRevNeph: New New & Views! @JeffMinerPhD discusses a GWAS study that identified an association between a COL4A3 variant and risk of D…

RT @NatRevNeph: New New & Views! @JeffMinerPhD discusses a GWAS study that identified an association between a COL4A3 variant and risk of D…

The benign #SNP Asp326Tyr protects agains #DKD. https://t.co/dukkAlyQ8v Preventing a deleterious #conformational change in the #tertiary structure of #collagen IV caused by #glycated Lys & Arg residues and associated #crosslinks modifying the #molecul

RT @NatRevNeph: New New & Views! @JeffMinerPhD discusses a GWAS study that identified an association between a COL4A3 variant and risk of D…

Anyone to bet against the assumption the link here is the propensity to increased #glycation of #collagen IV in #diabetics?

RT @NatRevNeph: New New & Views! @JeffMinerPhD discusses a GWAS study that identified an association between a COL4A3 variant and risk of D…

RT @NatRevNeph: New New & Views! @JeffMinerPhD discusses a GWAS study that identified an association between a COL4A3 variant and risk of D…

RT @NatRevNeph: New New & Views! @JeffMinerPhD discusses a GWAS study that identified an association between a COL4A3 variant and risk of D…

RT @NatRevNeph: New New & Views! @JeffMinerPhD discusses a GWAS study that identified an association between a COL4A3 variant and risk of D…

RT @NatRevNeph: New New & Views! @JeffMinerPhD discusses a GWAS study that identified an association between a COL4A3 variant and risk of D…

RT @NatRevNeph: New New & Views! @JeffMinerPhD discusses a GWAS study that identified an association between a COL4A3 variant and risk of D…

RT @NatRevNeph: New New & Views! @JeffMinerPhD discusses a GWAS study that identified an association between a COL4A3 variant and risk of D…

New New & Views! @JeffMinerPhD discusses a GWAS study that identified an association between a COL4A3 variant and risk of DKD in patients with T1DM: https://t.co/bqC5OY0aCF Original @JASN_News article here: https://t.co/mDM1e4eIkj https://t.co/k6ojP8w7

RT @thorpesd: Nice News and Views piece https://t.co/1110IFBJ49 highlighting @UCDDCRC collaborative work by Catherine Godson, Eoin Brennan…

Nice News and Views piece https://t.co/1110IFBJ49 highlighting @UCDDCRC collaborative work by Catherine Godson, Eoin Brennan and others identifying collagen IV's role in diabetic kidney disease @UCD_Conway @UCDMedicine https://t.co/Gk8zc5I0pY

RT @ASNKidney: New research identifies 16 genetic regions linked to diabetic kidney disease pointing to potential targets for prevention an…

RT @ASNKidney: New research identifies 16 genetic regions linked to diabetic kidney disease pointing to potential targets for prevention an…

RT @ASNKidney: New research identifies 16 genetic regions linked to diabetic kidney disease pointing to potential targets for prevention an…

RT @MPredictiva: Un estudio de asociación detecta 16 regiones del genoma relacionadas con la diabetes https://t.co/dY0PGdstKO #MedicinaPred…

RT @MPredictiva: Un estudio de asociación detecta 16 regiones del genoma relacionadas con la diabetes https://t.co/dY0PGdstKO #MedicinaPred…

RT @MPredictiva: Un estudio de asociación detecta 16 regiones del genoma relacionadas con la diabetes https://t.co/dY0PGdstKO #MedicinaPred…

So proud and pleased that this 20k T1D diabetic nephropathy study is finally out and that @jdrf helped to catalyse such a fantastic global collaboration. https://t.co/fxcQuSKrvO

RT @MPredictiva: Un estudio de asociación detecta 16 regiones del genoma relacionadas con la diabetes https://t.co/dY0PGdstKO #MedicinaPred…

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen. #amchelsinki #tutkimus https://t.co/jK9YxbdZtF

RT @MPredictiva: Un estudio de asociación detecta 16 regiones del genoma relacionadas con la diabetes https://t.co/dY0PGdstKO #MedicinaPred…

RT @MPredictiva: Un estudio de asociación detecta 16 regiones del genoma relacionadas con la diabetes https://t.co/dY0PGdstKO #MedicinaPred…

RT @MPredictiva: Un estudio de asociación detecta 16 regiones del genoma relacionadas con la diabetes https://t.co/dY0PGdstKO #MedicinaPred…

Un estudio de asociación detecta 16 regiones del genoma relacionadas con la diabetes https://t.co/dY0PGdstKO #MedicinaPredictiva

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen https://t.co/p12h3M6LBK

RT @KSusztak: GENIE is out. Large team lead by Jose Florez and Joel Hirshorn Genome-Wide Association Study of Diabetic Kidney Disease Highl…

RT @ASPNeph: Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen…

RT @ASPNeph: Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen…

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen https://t.co/zLMXmTZTU9 @JASN_News #Diabetes https://t.co/g3famzrvoH

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen. https://t.co/Vcf7P80Z7t

RT @UCDDCRC: New research from Prof Godson, Eoin Brennan, @darrell_1988 @doyle_ross, Maria Hugh's, the GENIE consortium &others may provide…

RT @UCDDCRC: New research from Prof Godson, Eoin Brennan, @darrell_1988 @doyle_ross, Maria Hugh's, the GENIE consortium &others may provide…

RT @UCDDCRC: New research from Prof Godson, Eoin Brennan, @darrell_1988 @doyle_ross, Maria Hugh's, the GENIE consortium &others may provide…

RT @ASNKidney: New research identifies 16 genetic regions linked to diabetic kidney disease pointing to potential targets for prevention an…

RT @ASNKidney: New research identifies 16 genetic regions linked to diabetic kidney disease pointing to potential targets for prevention an…

Link to our Diabetic Kidney Disease GWAS paper in JASN https://t.co/ahvqrLNYjJ

RT @npburtt: Query results from this wonderful study on the @T2DKP https://t.co/XwQNDyFawY

RT @KSusztak: GENIE is out. Large team lead by Jose Florez and Joel Hirshorn Genome-Wide Association Study of Diabetic Kidney Disease Highl…

RT @ASNKidney: New research identifies 16 genetic regions linked to diabetic kidney disease pointing to potential targets for prevention an…

RT @KSusztak: GENIE is out. Large team lead by Jose Florez and Joel Hirshorn Genome-Wide Association Study of Diabetic Kidney Disease Highl…

RT @ASNKidney: New research identifies 16 genetic regions linked to diabetic kidney disease pointing to potential targets for prevention an…

New research identifies 16 genetic regions linked to diabetic kidney disease pointing to potential targets for prevention and treatment | JASN For more, visit: https://t.co/f8PYGHWBaL https://t.co/YX5U5eYcnk

RT @KSusztak: GENIE is out. Large team lead by Jose Florez and Joel Hirshorn Genome-Wide Association Study of Diabetic Kidney Disease Highl…

Who’d have thought it ? Diabetic nephropathy and Alports syndrome ... it’s all in the genes 🧬.... Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen https://t.co/aLuTwQxtr8

RT @brendonneuen: Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Coll…

Friday Reading: #genetics #diabeticnephropathy #diabetes Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen https://t.co/Iy47zRDP2m

RT @ASNKidney: PUBLISHED BEFORE PRINT: NEW RESEARCH IDENTIFIES 16 GENETIC REGIONS LINKED TO DIABETIC KIDNEY DISEASE POINTING TO POTENTIAL T…

RT @JeffMinerPhD: This is a very important paper! Congrats to Jose Florez and colleagues on this achievement pointing to the importance of…

@S_brimble @JASN_News @MoumitaBaruaTO @KSusztak https://t.co/JtvPaYxE6A

RT @brendonneuen: Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Coll…

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen https://t.co/aAGCA27sT1 A spectacular paper in @JASN_News revealing new insights into diabetic kidney disease - congrats to every

RT @KSusztak: GENIE is out. Large team lead by Jose Florez and Joel Hirshorn Genome-Wide Association Study of Diabetic Kidney Disease Highl…

RT @KSusztak: GENIE is out. Large team lead by Jose Florez and Joel Hirshorn Genome-Wide Association Study of Diabetic Kidney Disease Highl…

New research from Prof Godson, Eoin Brennan, @darrell_1988 @doyle_ross, Maria Hugh's, the GENIE consortium &others may provide insight into the pathogenesis of Diabetic Kidney Disease and help identify potential biological targets for prevention&tr

RT @KSusztak: GENIE is out. Large team lead by Jose Florez and Joel Hirshorn Genome-Wide Association Study of Diabetic Kidney Disease Highl…

RT @ASNKidney: PUBLISHED BEFORE PRINT: NEW RESEARCH IDENTIFIES 16 GENETIC REGIONS LINKED TO DIABETIC KIDNEY DISEASE POINTING TO POTENTIAL T…

RT @P_Rossing: A major effort in understanding the background of kidney disease in diabetes from a great collaboration and so happy to be p…

RT @NiinaSandholm: Our GWAS on 19406 type 1 diabetics identified 16 novel loci for diabetic kidney disease (DKD)! A common missense snp in…

RT @KSusztak: GENIE is out. Large team lead by Jose Florez and Joel Hirshorn Genome-Wide Association Study of Diabetic Kidney Disease Highl…

A major effort in understanding the background of kidney disease in diabetes from a great collaboration and so happy to be part of this published in JASN Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology @stenodiabetes https://t.c

RT @KSusztak: GENIE is out. Large team lead by Jose Florez and Joel Hirshorn Genome-Wide Association Study of Diabetic Kidney Disease Highl…

New publication from FinnDiane group: https://t.co/owwOKTczut

RT @tsahluwalia: New genes and pathways underlying Diabetic Kidney Disease unravelled in a collaborative project on Individuals with Type 1…

Our GWAS on 19406 type 1 diabetics identified 16 novel loci for diabetic kidney disease (DKD)! A common missense snp in Collagen 4a3 is associated with thinner glomerular basement membrane and lowers risk of DKD by 20%. @FinnDianeStudy @FolkhalsanRC @helsi

RT @KSusztak: GENIE is out. Large team lead by Jose Florez and Joel Hirshorn Genome-Wide Association Study of Diabetic Kidney Disease Highl…

RT @KSusztak: GENIE is out. Large team lead by Jose Florez and Joel Hirshorn Genome-Wide Association Study of Diabetic Kidney Disease Highl…

RT @podocytes: Glad to see these important results published! Epilogue to @JeffMinerPhD’s “Year of Collagen IV”. Protective allele linked t…

RT @JeffMinerPhD: This is a very important paper! Congrats to Jose Florez and colleagues on this achievement pointing to the importance of…

New genes and pathways underlying Diabetic Kidney Disease unravelled in a collaborative project on Individuals with Type 1 Diabetes @Stenodiabetes @FinnDianeStudy @broadinstitute @UCSDHealth @wellcometrust @JoslinDiabetes @UMich @UniofOxford https://t.co/

This is cool. Nature medicine material. Great catch by JASN. Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen | American Society of Nephrology ⁦@JASN_News⁩ https://t.co/ogRzIcoR

RT @npburtt: Query results from this wonderful study on the @T2DKP https://t.co/XwQNDyFawY

RT @KSusztak: GENIE is out. Large team lead by Jose Florez and Joel Hirshorn Genome-Wide Association Study of Diabetic Kidney Disease Highl…

RT @JeffMinerPhD: This is a very important paper! Congrats to Jose Florez and colleagues on this achievement pointing to the importance of…

Query results from this wonderful study on the @T2DKP https://t.co/XwQNDyFawY

RT @KSusztak: GENIE is out. Large team lead by Jose Florez and Joel Hirshorn Genome-Wide Association Study of Diabetic Kidney Disease Highl…

GENIE is out. Large team lead by Jose Florez and Joel Hirshorn Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen | ⁦@JASN_News⁩ https://t.co/EqGJABiq9K

Our work on diabetic kidney disease is out. Large-scale GWAS identified 16 loci: COL4A3 (collagen) top signal, and BMP7, COLEC11 and DDR1 related to collagen/kidney function. Team effort, thanks to colleagues, participants and @JDRF for funding

Glad to see these important results published! Epilogue to @JeffMinerPhD’s “Year of Collagen IV”. Protective allele linked to thinner GBMs and Alport syndrome. ?counteracting the increased GBM thickness of diabetic nephropathy?

RT @JeffMinerPhD: This is a very important paper! Congrats to Jose Florez and colleagues on this achievement pointing to the importance of…

RT @JeffMinerPhD: This is a very important paper! Congrats to Jose Florez and colleagues on this achievement pointing to the importance of…

This is a very important paper! Congrats to Jose Florez and colleagues on this achievement pointing to the importance of COL4A3 variant status in driving or preventing diabetic kidney disease in type I diabetics.