RT @TristanRutland7: 4/ While urothelial carcinomas can have all of the above mutations, somatic alterations in the CDH1 gene occur in 84%…
RT @TristanRutland7: 4/ While urothelial carcinomas can have all of the above mutations, somatic alterations in the CDH1 gene occur in 84%…
4/ While urothelial carcinomas can have all of the above mutations, somatic alterations in the CDH1 gene occur in 84% (occurring to the paper below). 5/ Remember, gene encodes for E-cadherin (which is frequently loss in this subtype). https://t.co/m6MjKg
4/ While urothelial carcinomas can have all of the above mutations, somatic alterations in the CDH1 gene occur in 84% (occurring to the paper below). 5/ Remember, gene encodes for E-cadherin (which is frequently loss in this subtype). https://t.co/m6MjKg
4/ While urothelial carcinomas can have all of the above mutations, somatic alterations in the CDH1 gene occur in 84% (occurring to the paper below). 5/ Remember, gene encodes for E-cadherin (which is frequently loss in this subtype). https://t.co/m6MjKg
RT @MoHumrani: The stains are GATA3 (nuclear) and E-cadherin (crisp membranous). Few points about plasmacytoid UC: 🔴 associated with CDH1 m…
RT @MoHumrani: The stains are GATA3 (nuclear) and E-cadherin (crisp membranous). Few points about plasmacytoid UC: 🔴 associated with CDH1 m…
RT @MoHumrani: The stains are GATA3 (nuclear) and E-cadherin (crisp membranous). Few points about plasmacytoid UC: 🔴 associated with CDH1 m…
RT @MaxKates: @MehrazinMD @BladderCancerUS closest analogy is small cell cancer in that we probably should be looking to other malignancies…
@MehrazinMD @BladderCancerUS closest analogy is small cell cancer in that we probably should be looking to other malignancies outside of bladder cancer to gain insights on correct treatment paradigm.But @h_alahmadie and @DSolit showed genomics appear equ
RT @EdiBrogi: GATA3+, ER-: Not to be confused with metastatic lobular carcinoma! #breastpath #MSKpath https://t.co/uf9WbEJEWt
RT @drmehrarohit: Loss of Ecadherin by IHC (assoc with CDH1 mutation) can be very helpful diagnostically in plasmacytoid UCA- See our relat…
RT @drmehrarohit: Loss of Ecadherin by IHC (assoc with CDH1 mutation) can be very helpful diagnostically in plasmacytoid UCA- See our relat…
RT @drmehrarohit: Loss of Ecadherin by IHC (assoc with CDH1 mutation) can be very helpful diagnostically in plasmacytoid UCA- See our relat…
RT @drmehrarohit: Loss of Ecadherin by IHC (assoc with CDH1 mutation) can be very helpful diagnostically in plasmacytoid UCA- See our relat…
RT @drmehrarohit: Loss of Ecadherin by IHC (assoc with CDH1 mutation) can be very helpful diagnostically in plasmacytoid UCA- See our relat…
RT @drmehrarohit: Loss of Ecadherin by IHC (assoc with CDH1 mutation) can be very helpful diagnostically in plasmacytoid UCA- See our relat…
RT @drmehrarohit: Loss of Ecadherin by IHC (assoc with CDH1 mutation) can be very helpful diagnostically in plasmacytoid UCA- See our relat…
RT @drmehrarohit: Loss of Ecadherin by IHC (assoc with CDH1 mutation) can be very helpful diagnostically in plasmacytoid UCA- See our relat…
RT @drmehrarohit: Loss of Ecadherin by IHC (assoc with CDH1 mutation) can be very helpful diagnostically in plasmacytoid UCA- See our relat…
RT @drmehrarohit: Loss of Ecadherin by IHC (assoc with CDH1 mutation) can be very helpful diagnostically in plasmacytoid UCA- See our relat…
Loss of Ecadherin by IHC (assoc with CDH1 mutation) can be very helpful diagnostically in plasmacytoid UCA- See our related papers https://t.co/3t6JYtjbfi https://t.co/6cOQxpya6Y #gupath #bladdercancer @AcademicChatter https://t.co/4NkSmDQs0e
Issue with Plasmacytoid Bladder Cancer: Biology of the Disease not fully connected yet to the Clinical Course (fascial/peritoneal tracking etc). Wonderful work below helps and prior work by @h_alahmadie @DSolit point to SDH1 loss https://t.co/w56IdYfbyd.
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @lalpritu: Genetics defines morphology. Astute pathologists pick up subtle morphological differences in what others see as similar and h…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @lalpritu: Genetics defines morphology. Astute pathologists pick up subtle morphological differences in what others see as similar and h…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @lalpritu: Genetics defines morphology. Astute pathologists pick up subtle morphological differences in what others see as similar and h…
RT @lalpritu: Genetics defines morphology. Astute pathologists pick up subtle morphological differences in what others see as similar and h…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @lalpritu: Genetics defines morphology. Astute pathologists pick up subtle morphological differences in what others see as similar and h…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @lalpritu: Genetics defines morphology. Astute pathologists pick up subtle morphological differences in what others see as similar and h…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @lalpritu: Genetics defines morphology. Astute pathologists pick up subtle morphological differences in what others see as similar and h…
RT @lalpritu: Genetics defines morphology. Astute pathologists pick up subtle morphological differences in what others see as similar and h…
RT @lalpritu: Genetics defines morphology. Astute pathologists pick up subtle morphological differences in what others see as similar and h…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
Genetics defines morphology. Astute pathologists pick up subtle morphological differences in what others see as similar and help drive identification of entities and the cycle of discovery and translation. #pathology #gupath #molpath Great example of pla
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
RT @feidng: Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphol…
Most plasmacytoid variant urothelial carcinomas have mutations in CDH1 (E-cadherin), illustrative of how genetics shape morphology. https://t.co/dAWunxnJNF This one also has small cell carcinoma (right). Both components have loss of E-cadherin and RB1. #pa
@rovingatuscap @h_alahmadie @Unclassified1 @sirints @MLadanyi @AGMSKCC @UrologyMSK (2/3) CDH1 loss of function alterations and plasmacytoid morphology in lobular breast carcinoma, diffuse gastric carcinoma and plasmacytoid urothelial carcinoma: https://t.c
RT @drmehrarohit: Classic case of invasive urothelial carcinoma with plasmacytoid/signet ring/diffuse growth pattern; very aggressive tumor…
RT @drmehrarohit: Classic case of invasive urothelial carcinoma with plasmacytoid/signet ring/diffuse growth pattern; very aggressive tumor…
RT @drmehrarohit: Classic case of invasive urothelial carcinoma with plasmacytoid/signet ring/diffuse growth pattern; very aggressive tumor…
RT @bbmdmsk: Plasmacytoid #BladderCancer an enormous challenge. Some impressive respn to preop #chemotherapy. #DNA repair gene #mutations…
RT @bbmdmsk: Plasmacytoid #BladderCancer an enormous challenge. Some impressive respn to preop #chemotherapy. #DNA repair gene #mutations…
RT @bbmdmsk: Plasmacytoid #BladderCancer an enormous challenge. Some impressive respn to preop #chemotherapy. #DNA repair gene #mutations…
RT @bbmdmsk: Plasmacytoid #BladderCancer an enormous challenge. Some impressive respn to preop #chemotherapy. #DNA repair gene #mutations…
Plasmacytoid #BladderCancer an enormous challenge. Some impressive respn to preop #chemotherapy. #DNA repair gene #mutations matching up with some pT0 long term survivors. New #tumormarker for treatment selection of these pts? https://t.co/m4pO3z2uoz @sl
RT @drmehrarohit: Classic case of invasive urothelial carcinoma with plasmacytoid/signet ring/diffuse growth pattern; very aggressive tumor…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
RT @dannyjlubinpath: Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prog…
Middle age M w hematuria Plasmacytoid urothelial CA: *Usually advanced stage *Often p/w linitis plastica *Worse prognosis than conventional UC *Most w loss of E-cadherin, mutated CDH1 (truncating mutations most common) *Most (~60%) lack expression of RB
RT @drmehrarohit: Classic case of invasive urothelial carcinoma with plasmacytoid/signet ring/diffuse growth pattern; very aggressive tumor…
RT @drmehrarohit: Classic case of invasive urothelial carcinoma with plasmacytoid/signet ring/diffuse growth pattern; very aggressive tumor…
RT @drmehrarohit: Classic case of invasive urothelial carcinoma with plasmacytoid/signet ring/diffuse growth pattern; very aggressive tumor…
RT @drmehrarohit: Classic case of invasive urothelial carcinoma with plasmacytoid/signet ring/diffuse growth pattern; very aggressive tumor…
RT @drmehrarohit: Classic case of invasive urothelial carcinoma with plasmacytoid/signet ring/diffuse growth pattern; very aggressive tumor…
RT @drmehrarohit: Classic case of invasive urothelial carcinoma with plasmacytoid/signet ring/diffuse growth pattern; very aggressive tumor…
RT @drmehrarohit: Classic case of invasive urothelial carcinoma with plasmacytoid/signet ring/diffuse growth pattern; very aggressive tumor…