James Pickett @JamesPickett12 @alzheimerssoc, noted the @MathiasJucker study https://t.co/mTe7cLlso8 had limitations, including that it only looked at those who had a genetic predisposition to Alzheimer’s – which only affects 1% of those with the condition
Very cool @MathiasJucker love a reprint!
@MikeNGladstone @SaraNayeem Similar to previous DIAN study. DIAN study looked at APP/PSEN1/PSEN2 while here everyone has PSEN1. The DIAN study showed sig serum NfL at 16.2 yrs vs 22. Both very relatable. Very reminiscent of Dr. Nancy Wexler's work in Barr
Link to Preische et al (NMED 2019) as well https://t.co/c3ZmLECdwd
RT @dkegel: A blood test is said to predict alzheimers: https://t.co/D9T4J1ezf3 And tau-pet imaging is said to predict location of brain s…
A blood test is said to predict alzheimers: https://t.co/D9T4J1ezf3 And tau-pet imaging is said to predict location of brain shrinkage: https://t.co/fmLKXbEkn9 Seem to be an exiting time. Now if only the excitement would translate into clinical tests/tr
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease https://t.co/NAkiDHdcg0 https://t.co/3TDameP15J
@G_Commish @BillGates @JohnCendpts Amyloid proteins are triggers of disease, neuronal degradation occurs independently. Thus, only conditionally suitable for diagnosing Alzheimer’s, to show the course of the disease (a powerful instrument for investigating
RT @NatureMedicine: In a longitudinal cohort of familial #Alzheimers disease patients, the rate of change of blood biomarker levels identif…
RT @NatureMedicine: In a longitudinal cohort of familial #Alzheimers disease patients, the rate of change of blood biomarker levels identif…
En un estudio longitudinal, encuentran biomarcadores sanguíneos que indican neurodegeneración y declive cognitivo 👇
RT @NatureMedicine: In a longitudinal cohort of familial #Alzheimers disease patients, the rate of change of blood biomarker levels identif…
In a longitudinal cohort of familial #Alzheimers disease patients, the rate of change of blood biomarker levels identifies disease carriers much earlier than absolute levels and predicts both #neurodegeneration and cognitive decline: https://t.co/9WkN0tiRy
https://t.co/fMHNcymiMH "Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's Disease" This will help millions of people to prevent the progression of the disease and identify appropriate therapeuti
RT @NeuroBioMed: ...covering work from Mathias Jucker's group on #neurofilament and Betza Zlokovic's group on blood-brain barrier dysfuncti…
...covering work from Mathias Jucker's group on #neurofilament and Betza Zlokovic's group on blood-brain barrier dysfunction https://t.co/urs20FhcNu https://t.co/qfScqL1TuH
https://t.co/uJEQBswH8O https://t.co/cmAOwetPEw diagnoses decades in adv preexistings really an obsolete concept but still trump jungle med all older who left coverage get tossed into preexisting not orig an issue for them if medicare shafted is falling ou
A blood test for NfL, Neurofilament Light chain protein, may predict if Alzheimer"s Disease with develop 16 years before the patient with Familial Alzheimer's Dz. https://t.co/sZZMSZZlHt @ACEPNow @EmergencyDocs @alzassociation @alzheimerssoc
少し前の論文(2019年1月)やけど、家族性アルツハイマー病の変異遺伝子を持つヒトの血中で、ニューロフィラメントが発症の約15年前から増加し始めるという報告があった。@NatureMedicine https://t.co/RgjY4hdptX
One of the most convincing studies so far on a blood based biomarker test that shows early sensitivity to neurodegeneration: https://t.co/UHBXT3iM6N
Recent research reveals predictive blood biomarker for Alzheimer's disease. Changes in blood levels of neurofilament light chain (NfL) protein over time can help predict neurodegeneration years before clinical symptoms arise https://t.co/YaWQ254cgH
Neurofilament light chain (NfL), a potential "novel" biomarker (in CSF or blood!) for progressive #Alzheimer disease: predicts #cortical thinning and #cognitive (#MMSE & LMT) changes. Longitudinal NfL change beats absolute levels @NatureMedicine @DZNE
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease https://t.co/6QUMDBiZCU
Kaynak: https://t.co/bvrnJoRrz3
RT @SatchinPanda: Serum Nuerofilament light chain level can be a predictor of familial #Alzheimers disease. Change in serum level of NfL ca…
RT @SatchinPanda: Serum Nuerofilament light chain level can be a predictor of familial #Alzheimers disease. Change in serum level of NfL ca…
RT @DrJackKruse: More on how redox links to protein folding......OSF series 101. https://t.co/uoWUvbQwk8
RT @SatchinPanda: Serum Nuerofilament light chain level can be a predictor of familial #Alzheimers disease. Change in serum level of NfL ca…
RT @SatchinPanda: Serum Nuerofilament light chain level can be a predictor of familial #Alzheimers disease. Change in serum level of NfL ca…
RT @SatchinPanda: Serum Nuerofilament light chain level can be a predictor of familial #Alzheimers disease. Change in serum level of NfL ca…
RT @SatchinPanda: Serum Nuerofilament light chain level can be a predictor of familial #Alzheimers disease. Change in serum level of NfL ca…
RT @SatchinPanda: Serum Nuerofilament light chain level can be a predictor of familial #Alzheimers disease. Change in serum level of NfL ca…
RT @SatchinPanda: Serum Nuerofilament light chain level can be a predictor of familial #Alzheimers disease. Change in serum level of NfL ca…
RT @SatchinPanda: Serum Nuerofilament light chain level can be a predictor of familial #Alzheimers disease. Change in serum level of NfL ca…
More on how redox links to protein folding......OSF series 101.
血清ニューロフィラメント軽鎖レベルは家族性アルツハイマー病の予測因子となる。 NfLの血清レベルの変化は、症状が現れるほぼ16年前に疾患を予測することができる。 https://t.co/IjcFmsaMN3 #アルツハイマー
RT @SatchinPanda: Serum Nuerofilament light chain level can be a predictor of familial #Alzheimers disease. Change in serum level of NfL ca…
Serum Nuerofilament light chain level can be a predictor of familial #Alzheimers disease. Change in serum level of NfL can predict the disease by almost 16 years before the symptom appear. @NatureMedicine https://t.co/tF4s7c1fC2 https://t.co/xfVYERNNTE
Das man #Alzheimer 16 Jahre vor Auftreten von Symptomen vorhersagen kann, ist wissenschaftlich super, nur was hilft es dem Patienten, solange es kein Medikament gibt? Es wäre unethisch und gefährlich, sollte der Test die Marktzulassung erreichen! #Previvor
RT @daperezm: Neurofilamentos de cadena ligera en plasma como predictores hiperprecoces (hasta 16 años!!) de Enf. Alzheimer. Hoy se publica…
Finally!!!! 🙌🏻❤️🙌🏻
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease via @NatureMedicine https://t.co/PCynR7HHtv https://t.co/mnvNgfwpyh
Blood test to measure the amount of the protein called 'neurofilament light chain' may be able to predict the on-set of Alzheimer's disease before disease symptoms appear. https://t.co/BAcCYC4zoB
Protein Changes Detected in Blood Years Before Alzheimer’s Onset https://t.co/Qr9srT0CEn
NfL dynamics in serum predict disease progression and brain neurodegeneration at the early presymptomatic stages of familial Alzheimer’s disease, which supports its potential utility as a clinically useful biomarker. https://t.co/GF8UfLQvgZ
Scientists have found a blood protein, Neurofilament lilght chain, that can be used to precisely monitor Alzheimer's disease progression long before first clinical signs appear. This blood marker offers new possibilities for testing therapies. Read More: h
Kudos to the authors of this paper and @NatureMedicine for their dedication to good reporting, data availability, code availability, statistical package referencing and Bayesian approach - we have a long way to go, but such examples are super encouraging!
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease https://t.co/ThUjthfXvn
Potential useful biomarker for Alzheimer's https://t.co/l7nChnecQZ
RT @ciberned: #Investigación Las alteraciones en los niveles en sangre de la proteína NfL podrían revelar daños en el cerebro más de una dé…
Neurofilament light chain is a promising biomarker for familial Alzheimer's via @NatureMedicine https://t.co/xr45LGFxnk https://t.co/5gZdVHamhN
Descubren una proteína que puede ser detectada en sangre y actuar como biomarcador del alzheimer hasta 16 años antes de desarrollar la enfermedad. https://t.co/6CtVZ1MxGb https://t.co/eu0buzMxOj
#Investigación Las alteraciones en los niveles en sangre de la proteína NfL podrían revelar daños en el cerebro más de una década antes de que los síntomas de la enfermedad de #Alzheimer se manifiesten. Investigación ha sido desarrollada por el @DZNE_de h
Os dejo el enlace al artículo dónde bien el desarrollo de este descubrimiento. está en inglés https://t.co/BIQsBb0z3T https://t.co/iPvhLlDy7g
#Alzheimer: un biomarcador podría predecir la degeneración neuronal antes de la aparición de los síntomas en ciertas formas familiares de la enfermedad. https://t.co/78mn9673Zo https://t.co/VAoSj6hpgp
RT @polyplexors: According to a new study, a simple blood test reliably detects signs of brain damage in people on the path to developing A…
According to a new study, a simple blood test reliably detects signs of brain damage in people on the path to developing Alzheimer's disease—even before they show signs of confusion and memory loss. https://t.co/NDCL4mQUfJ #Alzheimers #healthsci #sciencetw
初期のアルツハイマーに関しては、血中タンパク質をモニターにするのが良さそうという話。
RT @EricTopol: A "Holy Grail" lab test would be one that accurately predicts #Alzheimers long before there are any symptoms. That's what se…
We're back! Exciting updates on CITAC member achievements to follow. In the meantime, read up on exciting developments with serum NfL https://t.co/yaw85xr3wc
Neurofilament dynamics in serum predict disease progression and brain neurodegeneration at the early presymptomatic stages of familial Alzheimer’s disease, which supports its potential utility as a clinically useful biomarker. https://t.co/AX1YQVfarD
RT @Biosensis: German researchers have shown that serum #Neurofilament light chain (NfL) levels are reliable predictors of #Alzheimer’s dis…
RT @NatureMedicine: In a longitudinal cohort of familial #Alzheimers disease patients, the rate of change of blood biomarker levels identif…
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease via Nature Medicine https://t.co/4EX60QpV0F https://t.co/1WCduiQRmt
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease https://t.co/XubeUBvgeJ
RT @EricTopol: A "Holy Grail" lab test would be one that accurately predicts #Alzheimers long before there are any symptoms. That's what se…
RT @NatureMedicine: In a longitudinal cohort of familial #Alzheimers disease patients, the rate of change of blood biomarker levels identif…
RT @EricTopol: A "Holy Grail" lab test would be one that accurately predicts #Alzheimers long before there are any symptoms. That's what se…
My colleague oliver published this fantastic study on blood biomarker in alzheimers
RT @NatureMedicine: In a longitudinal cohort of familial #Alzheimers disease patients, the rate of change of blood biomarker levels identif…
ネイチャー論文 https://t.co/sgrWjUOAfl
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease | Nature Medicine https://t.co/D1uJsXSqIL
RT @NatureMedicine: In a longitudinal cohort of familial #Alzheimers disease patients, the rate of change of blood biomarker levels identif…
¿Puede convertirse en una estrategia para la detección de Enfermedad de Alzheimer preclínico? https://t.co/Qbgeb1KyxS
RT @BioDecoded: Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease | Na…
Challenging silos & the technologies https://t.co/Cio6AaU9xr
RT @NatureMedicine: In a longitudinal cohort of familial #Alzheimers disease patients, the rate of change of blood biomarker levels identif…
RT @NatureMedicine: In a longitudinal cohort of familial #Alzheimers disease patients, the rate of change of blood biomarker levels identif…
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease | Nature Medicine https://t.co/svkZUyxrMj #alzheimers #biomarker https://t.co/diw66LC5JR
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease https://t.co/luoXZ58GHb
RT @EricTopol: A "Holy Grail" lab test would be one that accurately predicts #Alzheimers long before there are any symptoms. That's what se…
Blood biomarker as a predictor of #Alzheimer disease @NatureMedicine
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease | Nature Medicine https://t.co/i51uKN2vvg
Our grad students are awesome! Not to brag, but... In the same month, Austin McCullough has a 2nd author paper in Science Translational Medicine AND Stephanie Schultz is co-1st author in Nature Med !?https://t.co/FJEMled7HY https://t.co/lJGnMZ3Ve2 @Schultz
RT @ExponentialMed: A blood test may detect whether #Alzheimer's will develop 16 years before symptoms show, @nature study says https://t.…
RT @SPOREMOHAN: This work on neurofilament light chain could be game changing in early Alzheimers diagnosis; https://t.co/6GmhBTlcBp
RT @ExponentialMed: A blood test may detect whether #Alzheimer's will develop 16 years before symptoms show, @nature study says https://t.…