RT @HartungIngo: More on #PROTACs: Don't kid yourself about what it takes to come up with a highly cell-active protein degrader. It takes s…
RT @HartungIngo: More on #PROTACs: Don't kid yourself about what it takes to come up with a highly cell-active protein degrader. It takes s…
RT @HartungIngo: More on #PROTACs: Don't kid yourself about what it takes to come up with a highly cell-active protein degrader. It takes s…
RT @HartungIngo: More on #PROTACs: Don't kid yourself about what it takes to come up with a highly cell-active protein degrader. It takes s…
RT @HartungIngo: More on #PROTACs: Don't kid yourself about what it takes to come up with a highly cell-active protein degrader. It takes s…
RT @HartungIngo: More on #PROTACs: Don't kid yourself about what it takes to come up with a highly cell-active protein degrader. It takes s…
RT @HartungIngo: More on #PROTACs: Don't kid yourself about what it takes to come up with a highly cell-active protein degrader. It takes s…
RT @HartungIngo: More on #PROTACs: Don't kid yourself about what it takes to come up with a highly cell-active protein degrader. It takes s…
RT @HartungIngo: More on #PROTACs: Don't kid yourself about what it takes to come up with a highly cell-active protein degrader. It takes s…
More on #PROTACs: Don't kid yourself about what it takes to come up with a highly cell-active protein degrader. It takes serious synthetic chemistry muscles! Take this example about AR PROTACs from Shaomeng Wang's lab @MichiganChem published in @JMedChem:
RT @wgibson: PROTAC AR-69 completely degrades androgen receptor in prostate cancer cell lines. Seems as though issues w cell permeability a…
RT @mattschap: Rigid and soluble linker leads to #PROTAC that degrades AR in vivo https://t.co/Pq8fGFx86Q https://t.co/VGWgsQNQyM
RT @mattschap: Rigid and soluble linker leads to #PROTAC that degrades AR in vivo https://t.co/Pq8fGFx86Q https://t.co/VGWgsQNQyM
Rigid and soluble linker leads to #PROTAC that degrades AR in vivo https://t.co/Pq8fGFx86Q https://t.co/VGWgsQNQyM
RT @rkakamilan: Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Tr…
Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer https://t.co/kvwrJi3ihU
This looks very promising, also would be interesting to test interaction with radiation!
RT @RPNowak: ARD-69 as another AR degrader. From Shaomeng Wangs lab. Ligand variations and rigid linkers pay off. https://t.co/OHRfus0F0f
PROTAC AR-69 completely degrades androgen receptor in prostate cancer cell lines. Seems as though issues w cell permeability and complex synthesis finally resolving for protein-degrading PROTACs. Will be a big deal in clinic in <5 years. https://t.co/WP
RT @RPNowak: ARD-69 as another AR degrader. From Shaomeng Wangs lab. Ligand variations and rigid linkers pay off. https://t.co/OHRfus0F0f
RT @RPNowak: ARD-69 as another AR degrader. From Shaomeng Wangs lab. Ligand variations and rigid linkers pay off. https://t.co/OHRfus0F0f
RT @RPNowak: ARD-69 as another AR degrader. From Shaomeng Wangs lab. Ligand variations and rigid linkers pay off. https://t.co/OHRfus0F0f
RT @RPNowak: ARD-69 as another AR degrader. From Shaomeng Wangs lab. Ligand variations and rigid linkers pay off. https://t.co/OHRfus0F0f
RT @RPNowak: ARD-69 as another AR degrader. From Shaomeng Wangs lab. Ligand variations and rigid linkers pay off. https://t.co/OHRfus0F0f
RT @RPNowak: ARD-69 as another AR degrader. From Shaomeng Wangs lab. Ligand variations and rigid linkers pay off. https://t.co/OHRfus0F0f
ARD-69 as another AR degrader. From Shaomeng Wangs lab. Ligand variations and rigid linkers pay off. https://t.co/OHRfus0F0f
RT @yuukiwomanabu: この論文は入りには良さそう。合成も学べるし。 #学ぶの論文紹介 Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader o…
RT @yuukiwomanabu: この論文は入りには良さそう。合成も学べるし。 #学ぶの論文紹介 Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader o…
RT @yuukiwomanabu: この論文は入りには良さそう。合成も学べるし。 #学ぶの論文紹介 Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader o…
RT @yuukiwomanabu: この論文は入りには良さそう。合成も学べるし。 #学ぶの論文紹介 Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader o…
この論文は入りには良さそう。合成も学べるし。 #学ぶの論文紹介 Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer https://t.co/x19cHkasdG
Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer https://t.co/9UMcRy91Ca