Among 34 loci previously discovered in a large international GWAS (>33k subjects) https://t.co/hTb6K6d0hw, 31/34 were nominally associated with AMD in our cohort. 11/34 reached Bonferroni-corrected significance (0.05/34).
RT @Eric_Fauman: We've come a long way in 15 years. From neglogp of 7.4 for CFH for age related macular degeneration in 2005 to 617 in thi…
We've come a long way in 15 years. From neglogp of 7.4 for CFH for age related macular degeneration in 2005 to 617 in this 2016 GWAS: https://t.co/ZCi4PhqxkV
Still looking for any information on the ARMS2 locus for age-related macular degeneration. At a p-value of 1e-734 it is the strongest p-value for a disease where the causal gene is ambiguous (at least to me). https://t.co/ZCi4PhqxkV
Together maybe we can fill in some of the gaps. So first one up is the strongest association for age related macular degeneration (nlp=734), from this paper: https://t.co/ZCi4PhqxkV Labeled as ARMS2-HTRA1 on chromosome 10 So which is it? https://t.co/s
@pastramimachine This one published in 2016? https://t.co/hjA1aP4GDS
RT @cecilejanssens: Age-related macular degeneration is my go-to example for a stellar polygenic risk score. Here, from 2016, a top *deci…
RT @cecilejanssens: Age-related macular degeneration is my go-to example for a stellar polygenic risk score. Here, from 2016, a top *deci…
RT @cecilejanssens: Age-related macular degeneration is my go-to example for a stellar polygenic risk score. Here, from 2016, a top *deci…
RT @cecilejanssens: Age-related macular degeneration is my go-to example for a stellar polygenic risk score. Here, from 2016, a top *deci…
RT @cecilejanssens: Age-related macular degeneration is my go-to example for a stellar polygenic risk score. Here, from 2016, a top *deci…
RT @cecilejanssens: Age-related macular degeneration is my go-to example for a stellar polygenic risk score. Here, from 2016, a top *deci…
RT @cecilejanssens: Age-related macular degeneration is my go-to example for a stellar polygenic risk score. Here, from 2016, a top *deci…
RT @cecilejanssens: Age-related macular degeneration is my go-to example for a stellar polygenic risk score. Here, from 2016, a top *deci…
RT @cecilejanssens: Age-related macular degeneration is my go-to example for a stellar polygenic risk score. Here, from 2016, a top *deci…
RT @cecilejanssens: Age-related macular degeneration is my go-to example for a stellar polygenic risk score. Here, from 2016, a top *deci…
Age-related macular degeneration is my go-to example for a stellar polygenic risk score. Here, from 2016, a top *decile* with a 44-fold risk of disease compared to lowest, and 34% of phenotypic variance explained. What other examples can I use? https:
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and com… https://t.co/PVCYBFfj6T
Recent report by International AMD Genomics Consortium shows almost 2X more genetic risk loci associated w/AMD https://t.co/XY7dposaDL https://t.co/Y3LmR8MUju
ICYMI, large study shows impact of rare & common variants on age-related macular degeneration. https://t.co/WE7dqmolPX
RT @docmmiller: Age-rel. Macular Degeneration #AMD gene research discovery related to genes TIMP & MMP9 https://t.co/3XSJuAdCgR https://t.…
Age-rel. Macular Degeneration #AMD gene research discovery related to genes TIMP & MMP9 https://t.co/3XSJuAdCgR https://t.co/UQMVmTiXdm
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and https://t.co/9yie0FW1vS
PubMed: A large genome-wide association study of age-related macular degeneration highlights contributions of rare… https://t.co/uk5MU8mpr6
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and… https://t.co/lqZTjbNQDK
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and… https://t.co/KE7JtIwXVS
RT @eurogene: GWAS age-related macular degeneration (AMD) of rare + common Nature Genetics https://t.co/Ml1B75Z5iM
RT @eurogene: GWAS age-related macular degeneration (AMD) of rare + common Nature Genetics https://t.co/Ml1B75Z5iM
A large GWAS of age-related macular degeneration highlights contributions of rare + common variants https://t.co/6mJWBGngk9
GWAS age-related macular degeneration (AMD) of rare + common Nature Genetics https://t.co/Ml1B75Z5iM
rare coding variants pinpoint causal genes within known genetic loci: A large GWAS of AMD highlights contributions.. https://t.co/soeOT8EdE0
Large GWAS finds 34 loci =, 16 novel, associated with age-related macular degeneration https://t.co/0fDbEEgsdG https://t.co/oqGPuYr73O
Paper: Genetic insights into #AMD, includes contribution from Hayward group at MRC HGU @EdinburghUni https://t.co/I7TdsBoBgK
Our paper in @NatureGenet provides a better understanding of the relative roles of rare and common variants in AMD https://t.co/R3N15RUjqd
It's both common & rare variants underpinning age-related macular degen (like most diseases) https://t.co/2OijVy6fLw https://t.co/yCmWnrGwua
RT @NeurologyToday: New genetic insights into age-related macular degeneration https://t.co/x52qbNGQir
RT @NeurologyToday: New genetic insights into age-related macular degeneration https://t.co/x52qbNGQir
RT @NeurologyToday: New genetic insights into age-related macular degeneration https://t.co/x52qbNGQir
New genetic insights into age-related macular degeneration https://t.co/x52qbNGQir
RT @NeuroGen_papers: PubMed: A large genome-wide association study of age-related macular degeneration highlights contributions of rare… ht…
PubMed: A large genome-wide association study of age-related macular degeneration highlights contributions of rare… https://t.co/tLGcezMddH
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and… https://t.co/EVYfbyNeJ1
RT @skathire: HDL & eye dz: CETP variant, lower HDL, lower AMD risk!; ? implication CETPi that raise HDL? https://t.co/cnlCnAusYC https://t…
RT @skathire: HDL & eye dz: CETP variant, lower HDL, lower AMD risk!; ? implication CETPi that raise HDL? https://t.co/cnlCnAusYC https://t…
RT @skathire: HDL & eye dz: CETP variant, lower HDL, lower AMD risk!; ? implication CETPi that raise HDL? https://t.co/cnlCnAusYC https://t…
HDL & eye dz: CETP variant, lower HDL, lower AMD risk!; ? implication CETPi that raise HDL? https://t.co/cnlCnAusYC https://t.co/EtJdFQe3aU
A large genome-wide association study of age-related macular degeneration highlights... https://t.co/TBLHfP4Hnm
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and… https://t.co/8JKtLdkgED
RT @westr: New genetic clues to #AMD @NatureGenet https://t.co/9jWcXFdPOW & https://t.co/ayiAL1OMo4 #PM101 #vision #blindness https://t.co/…
A large GWA study of age-related macular degeneration highlights contributions of rare and common variants https://t.co/xxsUol80NZ #genetics
RT @westr: New genetic clues to #AMD @NatureGenet https://t.co/9jWcXFdPOW & https://t.co/ayiAL1OMo4 #PM101 #vision #blindness https://t.co/…
Contribución de variantes genéticas raras y comunes a la degeneración macular relacionada con la edad https://t.co/scfUD5fzff
GWAS of age-related macular degeneration highlights contribution of rare & common variants https://t.co/xn7j0rz0Ho https://t.co/6dX02hKvTp
RT @westr: New genetic clues to #AMD @NatureGenet https://t.co/9jWcXFdPOW & https://t.co/ayiAL1OMo4 #PM101 #vision #blindness https://t.co/…
RT @HeyDrWilson: #STEM #Genetics A large genome-wide association study of age-related macular degeneration highlights contributi... https:/…
RT @NatureGenet: 52 genetic variants associated with age-related macular degeneration (Fritsche et al.): https://t.co/DTZvjLJnFV
#genomics A large genome-wide association study of age-related macular degeneration highlights contributions of ra… https://t.co/LulSOCGWaI
RT @NatureGenet: 52 genetic variants associated with age-related macular degeneration (Fritsche et al.): https://t.co/DTZvjLJnFV
52 genetic variants associated with age-related macular degeneration (Fritsche et al.): https://t.co/DTZvjLJnFV
#STEM #Genetics A large genome-wide association study of age-related macular degeneration highlights contributi... https://t.co/cwY09mHNCq
RT @westr: New genetic clues to #AMD @NatureGenet https://t.co/9jWcXFdPOW & https://t.co/ayiAL1OMo4 #PM101 #vision #blindness https://t.co/…
New genetic clues to #AMD @NatureGenet https://t.co/9jWcXFdPOW & https://t.co/ayiAL1OMo4 #PM101 #vision #blindness https://t.co/5kdeJm12Vw
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and… https://t.co/gkcgpnV1tO