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Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes

Overview of attention for article published in Cell Reports, July 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

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65 tweeters
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Title
Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes
Published in
Cell Reports, July 2018
DOI 10.1016/j.celrep.2018.06.019
Pubmed ID
Authors

Xu, Beibei, Allard, Camille, Alvarez-Mercado, Ana I., Fuselier, Taylor, Kim, Jun Ho, Coons, Laurel A., Hewitt, Sylvia C., Urano, Fumihiko, Korach, Kenneth S., Levin, Ellis R., Arvan, Peter, Floyd, Z. Elizabeth, Mauvais-Jarvis, Franck, Beibei Xu, Camille Allard, Ana I. Alvarez-Mercado, Taylor Fuselier, Jun Ho Kim, Laurel A. Coons, Sylvia C. Hewitt, Fumihiko Urano, Kenneth S. Korach, Ellis R. Levin, Peter Arvan, Z. Elizabeth Floyd, Franck Mauvais-Jarvis

Abstract

Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and β cell dysfunction. We show that CE prevent insulin-deficient diabetes in male and in female Akita mice using a model of misfolded proinsulin. CE stabilize the ER-associated protein degradation (ERAD) system and promote misfolded proinsulin proteasomal degradation. This involves activation of nuclear and membrane estrogen receptor-α (ERα), promoting transcriptional repression and proteasomal degradation of the ubiquitin-conjugating enzyme and ERAD degrader, UBC6e. The selective ERα modulator bazedoxifene mimics CE protection of β cells in females but not in males.

Twitter Demographics

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Attention Score in Context

This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#395,510
of 11,498,490 outputs
Outputs from Cell Reports
#978
of 5,027 outputs
Outputs of similar age
#10,696
of 153,613 outputs
Outputs of similar age from Cell Reports
#36
of 157 outputs
Altmetric has tracked 11,498,490 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,027 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 153,613 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 157 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.