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Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes

Overview of attention for article published in Cell Reports, July 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

twitter
64 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
2 Dimensions

Readers on

mendeley
20 Mendeley
Title
Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes
Published in
Cell Reports, July 2018
DOI 10.1016/j.celrep.2018.06.019
Pubmed ID
Authors

Xu, Beibei, Allard, Camille, Alvarez-Mercado, Ana I., Fuselier, Taylor, Kim, Jun Ho, Coons, Laurel A., Hewitt, Sylvia C., Urano, Fumihiko, Korach, Kenneth S., Levin, Ellis R., Arvan, Peter, Floyd, Z. Elizabeth, Mauvais-Jarvis, Franck, Beibei Xu, Camille Allard, Ana I. Alvarez-Mercado, Taylor Fuselier, Jun Ho Kim, Laurel A. Coons, Sylvia C. Hewitt, Fumihiko Urano, Kenneth S. Korach, Ellis R. Levin, Peter Arvan, Z. Elizabeth Floyd, Franck Mauvais-Jarvis

Abstract

Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and β cell dysfunction. We show that CE prevent insulin-deficient diabetes in male and in female Akita mice using a model of misfolded proinsulin. CE stabilize the ER-associated protein degradation (ERAD) system and promote misfolded proinsulin proteasomal degradation. This involves activation of nuclear and membrane estrogen receptor-α (ERα), promoting transcriptional repression and proteasomal degradation of the ubiquitin-conjugating enzyme and ERAD degrader, UBC6e. The selective ERα modulator bazedoxifene mimics CE protection of β cells in females but not in males.

Twitter Demographics

The data shown below were collected from the profiles of 64 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 30%
Researcher 3 15%
Student > Bachelor 3 15%
Student > Master 3 15%
Student > Postgraduate 1 5%
Other 4 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 35%
Biochemistry, Genetics and Molecular Biology 7 35%
Unspecified 3 15%
Immunology and Microbiology 2 10%
Medicine and Dentistry 1 5%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#434,538
of 11,918,812 outputs
Outputs from Cell Reports
#1,063
of 5,322 outputs
Outputs of similar age
#18,682
of 249,327 outputs
Outputs of similar age from Cell Reports
#75
of 294 outputs
Altmetric has tracked 11,918,812 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,322 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.1. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,327 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 294 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.