| Title |
NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort
|
|---|---|
| Published in |
Respiratory Medicine, June 2018
|
| DOI | 10.1016/j.rmed.2018.06.005 |
| Pubmed ID | |
| Authors |
Wassim W Labaki, Meng Xia, Susan Murray, Jeffrey L Curtis, R Graham Barr, Surya P Bhatt, Eugene R Bleecker, Nadia N Hansel, Christopher B Cooper, Mark T Dransfield, J Michael Wells, Eric A Hoffman, Richard E Kanner, Robert Paine, Victor E Ortega, Stephen P Peters, Jerry A Krishnan, Russell P Bowler, David J Couper, Prescott G Woodruff, Fernando J Martinez, Carlos H Martinez, MeiLan K Han |
| Abstract |
High N-terminal pro-brain natriuretic peptide (NT-proBNP) during COPD exacerbations is associated with worse clinical outcomes. The prognostic value of NT-proBNP measured during clinical stability has not been well characterized. We studied SPIROMICS participants 40-80 years of age with COPD GOLD spirometric stages 1-4. The association between baseline NT-proBNP and incident COPD exacerbations within one year of follow-up was tested using zero-inflated Poisson regression models adjusted for age, gender, race, body mass index, current smoking status, smoking history, FEV1 percent predicted, COPD Assessment Test score, exacerbation history, total lung capacity on chest CT and cardiovascular disease (any of coronary artery disease, myocardial infarction or congestive heart failure). Among 1051 participants (mean age 66.1 years, 41.4% women), mean NT-proBNP was 608.9 pg/ml. Subjects in GOLD stage D had the highest mean NT-proBNP. After one year of follow-up, 268 participants experienced one or more COPD exacerbations. One standard deviation increase in baseline NT-proBNP was associated with a 13% increase in the risk of incident exacerbations (incident risk ratio 1.13; 95% CI 1.06-1.19; p < 0.0001). This association was maintained in participants with and without cardiovascular disease. Baseline NT-proBNP in COPD is an independent predictor of respiratory exacerbations, even in individuals without overt cardiac disease. The impact of detection and treatment of early cardiovascular dysfunction on COPD exacerbation frequency warrants further investigation. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Venezuela, Bolivarian Republic of | 3 | 21% |
| Colombia | 2 | 14% |
| Bolivia, Plurinational State of | 1 | 7% |
| Ecuador | 1 | 7% |
| United States | 1 | 7% |
| Unknown | 6 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 79% |
| Science communicators (journalists, bloggers, editors) | 2 | 14% |
| Practitioners (doctors, other healthcare professionals) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 89 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 16% |
| Researcher | 7 | 8% |
| Student > Bachelor | 7 | 8% |
| Professor > Associate Professor | 4 | 4% |
| Student > Doctoral Student | 4 | 4% |
| Other | 10 | 11% |
| Unknown | 43 | 48% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 22% |
| Nursing and Health Professions | 11 | 12% |
| Agricultural and Biological Sciences | 2 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Biochemistry, Genetics and Molecular Biology | 1 | 1% |
| Other | 4 | 4% |
| Unknown | 49 | 55% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2018.
All research outputs
#5,213,149
of 25,382,440 outputs
Outputs from Respiratory Medicine
#900
of 3,571 outputs
Outputs of similar age
#93,139
of 343,126 outputs
Outputs of similar age from Respiratory Medicine
#11
of 43 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,571 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,126 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.