↓ Skip to main content

Michigan Publishing

Article Metrics

NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort

Overview of attention for article published in Respiratory Medicine, July 2018
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

twitter
15 tweeters

Readers on

mendeley
3 Mendeley
Title
NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort
Published in
Respiratory Medicine, July 2018
DOI 10.1016/j.rmed.2018.06.005
Pubmed ID
Authors

Wassim W. Labaki, Meng Xia, Susan Murray, Jeffrey L. Curtis, R. Graham Barr, Surya P. Bhatt, Eugene R. Bleecker, Nadia N. Hansel, Christopher B. Cooper, Mark T. Dransfield, J. Michael Wells, Eric A. Hoffman, Richard E. Kanner, Robert Paine, Victor E. Ortega, Stephen P. Peters, Jerry A. Krishnan, Russell P. Bowler, David J. Couper, Prescott G. Woodruff, Fernando J. Martinez, Carlos H. Martinez, MeiLan K. Han

Abstract

High N-terminal pro-brain natriuretic peptide (NT-proBNP) during COPD exacerbations is associated with worse clinical outcomes. The prognostic value of NT-proBNP measured during clinical stability has not been well characterized. We studied SPIROMICS participants 40-80 years of age with COPD GOLD spirometric stages 1-4. The association between baseline NT-proBNP and incident COPD exacerbations within one year of follow-up was tested using zero-inflated Poisson regression models adjusted for age, gender, race, body mass index, current smoking status, smoking history, FEV1 percent predicted, COPD Assessment Test score, exacerbation history, total lung capacity on chest CT and cardiovascular disease (any of coronary artery disease, myocardial infarction or congestive heart failure). Among 1051 participants (mean age 66.1 years, 41.4% women), mean NT-proBNP was 608.9 pg/ml. Subjects in GOLD stage D had the highest mean NT-proBNP. After one year of follow-up, 268 participants experienced one or more COPD exacerbations. One standard deviation increase in baseline NT-proBNP was associated with a 13% increase in the risk of incident exacerbations (incident risk ratio 1.13; 95% CI 1.06-1.19; p < 0.0001). This association was maintained in participants with and without cardiovascular disease. Baseline NT-proBNP in COPD is an independent predictor of respiratory exacerbations, even in individuals without overt cardiac disease. The impact of detection and treatment of early cardiovascular dysfunction on COPD exacerbation frequency warrants further investigation.

Twitter Demographics

The data shown below were collected from the profiles of 15 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 3 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 2 67%
Student > Master 1 33%
Readers by discipline Count As %
Unspecified 2 67%
Medicine and Dentistry 1 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2018.
All research outputs
#1,771,956
of 11,874,454 outputs
Outputs from Respiratory Medicine
#207
of 1,854 outputs
Outputs of similar age
#59,615
of 250,304 outputs
Outputs of similar age from Respiratory Medicine
#6
of 27 outputs
Altmetric has tracked 11,874,454 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,854 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,304 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.