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A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis

Overview of attention for article published in Nature Communications, June 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

news
7 news outlets
blogs
3 blogs
twitter
57 X users
facebook
2 Facebook pages

Citations

dimensions_citation
100 Dimensions

Readers on

mendeley
135 Mendeley
Title
A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis
Published in
Nature Communications, June 2018
DOI 10.1038/s41467-018-04648-0
Pubmed ID
Authors

Andrew Schrepf, Chelsea M. Kaplan, Eric Ichesco, Tony Larkin, Steven E. Harte, Richard E. Harris, Alison D. Murray, Gordon D. Waiter, Daniel J. Clauw, Neil Basu

Abstract

It is unknown how chronic inflammation impacts the brain. Here, we examined whether higher levels of peripheral inflammation were associated with brain connectivity and structure in 54 rheumatoid arthritis patients using functional and structural MRI. We show that higher levels of inflammation are associated with more positive connections between the inferior parietal lobule (IPL), medial prefrontal cortex, and multiple brain networks, as well as reduced IPL grey matter, and that these patterns of connectivity predicted fatigue, pain and cognitive dysfunction. At a second scan 6 months later, some of the same patterns of connectivity were again associated with higher peripheral inflammation. A graph theoretical analysis of whole-brain functional connectivity revealed a pattern of connections spanning 49 regions, including the IPL and medial frontal cortex, that are associated with peripheral inflammation. These regions may play a critical role in transducing peripheral inflammatory signals to the central changes seen in rheumatoid arthritis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 57 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 135 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 21%
Researcher 15 11%
Student > Master 13 10%
Student > Doctoral Student 10 7%
Student > Bachelor 7 5%
Other 20 15%
Unknown 42 31%
Readers by discipline Count As %
Medicine and Dentistry 24 18%
Neuroscience 18 13%
Agricultural and Biological Sciences 10 7%
Psychology 6 4%
Immunology and Microbiology 5 4%
Other 21 16%
Unknown 51 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 96. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2023.
All research outputs
#442,141
of 25,476,463 outputs
Outputs from Nature Communications
#7,367
of 57,239 outputs
Outputs of similar age
#9,718
of 342,401 outputs
Outputs of similar age from Nature Communications
#182
of 1,200 outputs
Altmetric has tracked 25,476,463 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 57,239 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.6. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,401 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1,200 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.