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A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis

Overview of attention for article published in Nature Communications, June 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

news
6 news outlets
blogs
3 blogs
twitter
53 tweeters

Citations

dimensions_citation
1 Dimensions

Readers on

mendeley
23 Mendeley
Title
A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis
Published in
Nature Communications, June 2018
DOI 10.1038/s41467-018-04648-0
Pubmed ID
Authors

Andrew Schrepf, Chelsea M. Kaplan, Eric Ichesco, Tony Larkin, Steven E. Harte, Richard E. Harris, Alison D. Murray, Gordon D. Waiter, Daniel J. Clauw, Neil Basu

Abstract

It is unknown how chronic inflammation impacts the brain. Here, we examined whether higher levels of peripheral inflammation were associated with brain connectivity and structure in 54 rheumatoid arthritis patients using functional and structural MRI. We show that higher levels of inflammation are associated with more positive connections between the inferior parietal lobule (IPL), medial prefrontal cortex, and multiple brain networks, as well as reduced IPL grey matter, and that these patterns of connectivity predicted fatigue, pain and cognitive dysfunction. At a second scan 6 months later, some of the same patterns of connectivity were again associated with higher peripheral inflammation. A graph theoretical analysis of whole-brain functional connectivity revealed a pattern of connections spanning 49 regions, including the IPL and medial frontal cortex, that are associated with peripheral inflammation. These regions may play a critical role in transducing peripheral inflammatory signals to the central changes seen in rheumatoid arthritis.

Twitter Demographics

The data shown below were collected from the profiles of 53 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 17%
Researcher 4 17%
Student > Master 3 13%
Student > Doctoral Student 3 13%
Student > Postgraduate 1 4%
Other 1 4%
Unknown 7 30%
Readers by discipline Count As %
Neuroscience 4 17%
Medicine and Dentistry 3 13%
Computer Science 2 9%
Psychology 1 4%
Agricultural and Biological Sciences 1 4%
Other 5 22%
Unknown 7 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 91. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2018.
All research outputs
#141,127
of 11,845,571 outputs
Outputs from Nature Communications
#2,573
of 18,505 outputs
Outputs of similar age
#7,249
of 255,604 outputs
Outputs of similar age from Nature Communications
#162
of 1,042 outputs
Altmetric has tracked 11,845,571 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 18,505 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 47.2. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,604 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1,042 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.