@sorahill Thus far, using obesity genetics, we have not been able to identify any signal for immunological cell types. https://t.co/xlfBGN85Cz https://t.co/GnS5Jhc4mn However, could be that the overwhelming neuronal enrichments obfuscate a less prevalen
First of all, being fat is to a significant extent genetic. That alone is enough to disprove WordBlind's claim that it's simple. Genetic studies of body mass index yield new insights for obesity biology https://t.co/xyZC9NZOWD
@Velez_Edwards @VUMCgenetics DVE: used BMI summary stats from https://t.co/clPFxwJPZQ BP from https://t.co/KCVj3DYJiL Used PrediXcan and used placental eQTL from Peng paper above - RI child heath study
Pathway analysis of GWAS of BMI finds that top hits are often in the CNS (e.g. https://t.co/ZGbxyKj2qa). Easy to emphasize nutrition. But real-world suggests the neuroendocrine loops driven by Western diets are hard to break (how many people regain weight
👉The written publication of the lecture https://t.co/jCaXs1BODS 👉Genetic studies of BMI https://t.co/veVPAMWFPu
@ahhite @angryhacademic @MichaelMindrum That’s the beauty of hypothesis-free methods: they don’t care about your beliefs. Step 1: GWAS BMI (& show all results): https://t.co/BwThquNu8c Step 2: Run BMI against all outcomes (& show all results, no
@michelnivard Not sure.. I double checked to see if it was a typo, and it's not. In the original BMI-GWAS paper (https://t.co/1Ml4hNCdCc), they do report to have been very stringent in their genomic control correction (they performed multiple GC correction
@lowcarbGP @Dr__Guess @BrownAdey Based on the substantial genetic component to variation in BMI, and the strong enrichment for genes operating in brain, no need to separate “hunger” from “behaviour” from “calories in”, “appetite” etc https://t.co/v12rlJ1iW
@joftius (1) That's not what I said. (2) BMI is a brain phenotype, not a digestive phenotype. See Figure 2: https://t.co/mbqdaqMQjO
Genetic studies of body mass index yield new insights for obesity biology. https://t.co/it58EG77i5
@CakeNutrition @JoslinDiabetes As I said the 4% number isnt untrue. Just the rest isnt environment. Locke et al https://t.co/CBawueexU1 modelled that the variants detected across whole population would eventually come to about 20% of the variance. Rest of
@garytaubes @KevinH_PhD This figure from https://t.co/3YFVFDjl77 might explain why not everyone gets fat. https://t.co/0sEZYEVe4F
RT @timfrayling: @ceclindgren @jflier @skathire @joelhirschhorn @markmccarthyoxf Here's the paper https://t.co/v12rlJ1iWw & key figure that…
RT @RosaCorcoy: - common genetic variations explain >20% BMI variation -pathway analysis suggest a strong role of BRAIN in obesity suscepti…
- common genetic variations explain >20% BMI variation -pathway analysis suggest a strong role of BRAIN in obesity susceptibility https://t.co/czKqIDUQaQ
RT @timfrayling: @ceclindgren @jflier @skathire @joelhirschhorn @markmccarthyoxf Here's the paper https://t.co/v12rlJ1iWw & key figure that…
RT @timfrayling: @ceclindgren @jflier @skathire @joelhirschhorn @markmccarthyoxf Here's the paper https://t.co/v12rlJ1iWw & key figure that…
RT @timfrayling: @ceclindgren @jflier @skathire @joelhirschhorn @markmccarthyoxf Here's the paper https://t.co/v12rlJ1iWw & key figure that…
RT @timfrayling: @ceclindgren @jflier @skathire @joelhirschhorn @markmccarthyoxf Here's the paper https://t.co/v12rlJ1iWw & key figure that…
@ceclindgren @jflier @skathire @joelhirschhorn @markmccarthyoxf Here's the paper https://t.co/v12rlJ1iWw & key figure that shows that GWAS has unequivocally highlighted the role of the brain in contributing to normal variation in BMI: https://t.co/fjdD
@antonioregalado Not sure what you want (h^2, broad, narrow or GCTA), but this paper got some numbers https://t.co/srTWgYxxkM
@JPatache es que no hablaba exclusivamente del artículo si no de eso y otras línea de investigación, p.ej. https://t.co/SAm5hiZSiN https://t.co/4YNIfU9Wzy
@adamjshay Yes. Common allele (rs10423928 near GIPR) assoc. with higher ins. secretion & higher BMI. https://t.co/m7ERyFZcdi & https://t.co/v12rlJ1iWw
@rkhamsi @NYTmag Neat article! Would add that there are many #genes that contribute to common #obesity (https://t.co/5MiPgwi8r4 and https://t.co/MdysUdolvk).
@KirkegaardEmil (part IIB, insights from human genetics, and Fiture 2 in this, 2015) https://t.co/o7wDwvMOgl https://t.co/SW2z3lujWZ
RT @PNGumich: #PNGresearch: Genetic studies of body mass index yield new insights for obesity biology https://t.co/2uB4P2OPpy
#PNGresearch: Genetic studies of body mass index yield new insights for obesity biology https://t.co/2uB4P2OPpy
@MariaJonsson1 Man har identifierat minst 97 genvarianter som är associerade med BMI https://t.co/9vS5ghUWRc Inte mitt område dock.
RT @whsource: Obesity genetics: "Pathway analyses provide strong support for a role of the central nervous system in obesity" https://t.co/…
RT @paulphel: @kidney_boy but even when genotyping >300k individuals, GWAS discovered loci explain <3% of BMI variation https://t.co/vj7q1a…
@kidney_boy but even when genotyping >300k individuals, GWAS discovered loci explain <3% of BMI variation https://t.co/vj7q1anz1A #kidneywk
RT @whsource: Obesity genetics: "Pathway analyses provide strong support for a role of the central nervous system in obesity" https://t.co/…
RT @whsource: Obesity genetics: "Pathway analyses provide strong support for a role of the central nervous system in obesity" https://t.co/…
RT @whsource: Obesity genetics: "Pathway analyses provide strong support for a role of the central nervous system in obesity" https://t.co/…
RT @whsource: Obesity genetics: "Pathway analyses provide strong support for a role of the central nervous system in obesity" https://t.co/…
Review: pathway genetic analysis identifies CNS as important for the development of obesity: https://t.co/Voxcz1lj0O
RT @whsource: Obesity genetics: "Pathway analyses provide strong support for a role of the central nervous system in obesity" https://t.co/…
RT @whsource: Obesity genetics: "Pathway analyses provide strong support for a role of the central nervous system in obesity" https://t.co/…
RT @whsource: Obesity genetics: "Pathway analyses provide strong support for a role of the central nervous system in obesity" https://t.co/…
RT @whsource: Obesity genetics: "Pathway analyses provide strong support for a role of the central nervous system in obesity" https://t.co/…
RT @whsource: Obesity genetics: "Pathway analyses provide strong support for a role of the central nervous system in obesity" https://t.co/…
RT @whsource: Obesity genetics: "Pathway analyses provide strong support for a role of the central nervous system in obesity" https://t.co/…
Genetics, BMI, and new insight into obesity biology: https://t.co/8UmRa9HZXf
RT @whsource: Obesity genetics: "Pathway analyses provide strong support for a role of the central nervous system in obesity" https://t.co/…
RT @whsource: Obesity genetics: "Pathway analyses provide strong support for a role of the central nervous system in obesity" https://t.co/…
RT @whsource: Obesity genetics: "Pathway analyses provide strong support for a role of the central nervous system in obesity" https://t.co/…
Obesity genetics: "Pathway analyses provide strong support for a role of the central nervous system in obesity" https://t.co/BWbR4r4cgt
Great work https://t.co/lWtPhvBceb
RT @dr_kevinlee: Where do your genes fit when you can't fit in your jeans? #GWAS analysis https://t.co/GPRehC4rLj https://t.co/CTBLpNIOZg
Where do your genes fit when you can't fit in your jeans? #GWAS analysis https://t.co/GPRehC4rLj https://t.co/CTBLpNIOZg
@PatSchloss more accurately: heritability estimate 40-70%, common genetic variation explains 20% of BMI variation https://t.co/OpWjNxKZbi
@brujaoculta y para genómica, o sea, estudios moleculares y no poblacionales con gemelos, adoptados y así https://t.co/LvO8Jxg1rE
Genetic studies of body mass index yield new insights for obesity biology https://t.co/xgfP9nqC9r
@EnderRaptor "few genes"? do you have anything against papers like https://t.co/lcuOgrpUOq that show additive effect in human obesity?
RT @NanciGuestRD: Up to 21% of #BMI variation / #Obesity due to genetic var. Many are #CNS SNPs @NeilFlochMD https://t.co/VYeGdD32TW https…
RT @NanciGuestRD: Up to 21% of #BMI variation / #Obesity due to genetic var. Many are #CNS SNPs @NeilFlochMD https://t.co/VYeGdD32TW https…
Up to 21% of #BMI variation / #Obesity due to genetic var. Many are #CNS SNPs @NeilFlochMD https://t.co/VYeGdD32TW https://t.co/1tarf4dRVm
@IWFBuckley @Mangan150 see for example https://t.co/ToEA4Gc9I9
RT @T2Diabetesgenes: Sugary drink tax reduces consumption: https://t.co/lE4mFoMomJ & is consistent with biology learnt from obesity GWAS: h…
Sugary drink tax reduces consumption: https://t.co/lE4mFoMomJ & is consistent with biology learnt from obesity GWAS: https://t.co/hqBree6g2L
97 #genetic variants identified that influence #BMI, of which 56 are novel: http://t.co/Hzdu1EZUem @nature http://t.co/zH7IyizwIC
@markmccarthyoxf @dgmacarthur @mendel_random thanks. what's a "truncation effect"? FTO shows up here: http://t.co/2t3B9Pii6g
Obesity = more then only eating, mostly Brain (Nature, 2015): http://t.co/I1M1nw3BVa & also Schizo- Region 16p11.2: http://t.co/xVumn1sveJ
Obesity = more then only eating, mostly Brain (Nature, 2015): http://t.co/I1M1nw3BVa & also Schizo- Region 16p11.2: http://t.co/xVumn1sveJ
frente a >50% en otros. Por mucho que sean más informativos de los genes concretos como en este sobre obesidad http://t.co/LvO8Jxg1rE
"Obesity genetics is brain genetics: 27 out of 31 significantly enriched tissues were in the central nervous system" http://t.co/LvO8Jxg1rE
Genetic BMI studies in 340,000 individuals suggest a CNS role in obesity susceptibility http://t.co/gMma9RG8QZ
@brianedwardsmd Nature: analysis 97 BMI-associated loci http://t.co/4OCd7o2aMn Feb 2015 @SethJBaumMD @lipiddoc Exercise negates genes
Omgeving belangrijker voor vetzucht dan genen. Verschillen in BMI grotendeels (97%) niet verklaarbaar uit DNA. http://t.co/rEuZSAU4Z5
Omgeving belangrijker voor vetzucht dan genen. Verschillen in BMI grotendeels (97%) niet verklaarbaar uit DNA. http://t.co/rEuZSAU4Z5
Omgeving belangrijker voor vetzucht dan genen. Verschillen in BMI grotendeels (97%) niet verklaarbaar uit DNA. http://t.co/rEuZSAU4Z5
Omgeving belangrijker voor vetzucht dan genen. Verschillen in BMI grotendeels (97%) niet verklaarbaar uit DNA http://t.co/wveiFDf7Pu
RT @StephanDenHaag: Omgeving belangrijker voor vetzucht dan genen. http://t.co/4OXTTsWsaT
RT @StephanDenHaag: Omgeving belangrijker voor vetzucht dan genen. http://t.co/4OXTTsWsaT
Omgeving belangrijker voor vetzucht dan genen. Verschillen in BMI grotendeels (97%) niet verklaarbaar uit DNA http://t.co/wveiFDf7Pu
Omgeving belangrijker voor vetzucht dan genen. Verschillen in BMI grotendeels (97%) niet verklaarbaar uit DNA. http://t.co/rEuZSAU4Z5
Omgeving belangrijker voor vetzucht dan genen. Verschillen in BMI grotendeels (97%) niet verklaarbaar uit DNA. http://t.co/rEuZSAU4Z5
Omgeving belangrijker voor vetzucht dan genen. Verschillen in BMI grotendeels (97%) niet verklaarbaar uit DNA. http://t.co/rEuZSAU4Z5
Omgeving belangrijker voor vetzucht dan genen. Verschillen in BMI grotendeels (97%) niet verklaarbaar uit DNA. http://t.co/rEuZSAU4Z5
Omgeving belangrijker voor vetzucht dan genen. Verschillen in BMI grotendeels (97%) niet verklaarbaar uit DNA. http://t.co/rEuZSAU4Z5
Genetic studies of body mass index yield new insights for obesity biology http://t.co/ux83mPV6R6
Genetic studies of body mass index yield new insights for obesity biology: http://t.co/MAlZmB8JLm
#obesity #genomics MT @casey6r0wn: Latest BMI #GWAS: 97 SNPs explain 3% phenotype variance, 2.3k SNPs 7%.. http://t.co/yY6AdNPJjH
Latest BMI GWAS: 97 SNPs explain 3% phenotype variance, 2.3k SNPs 7%, all tagged variants 22% Infinitesimal model... http://t.co/spErWvTf4K
Latest BMI GWAS: 97 SNPs explain 3% phenotype variance, 2.3k SNPs 7%, all tagged variants 22% Infinitesimal model... http://t.co/spErWvTf4K
Latest BMI GWAS: 97 SNPs explain 3% phenotype variance, 2.3k SNPs 7%, all tagged variants 22% Infinitesimal model... http://t.co/spErWvTf4K
Genetic studies of body mass index yield new insights for obesity biology: http://t.co/MAlZmB8JLm
Genetic studies of body mass index yield new insights for obesity biology: http://t.co/MAlZmB8JLm
@IntraMednet http://t.co/Ansx50r5UJ GWAs realizado en más de 320.000 paciente. Muy recomendable su lectura
@IntraMednet http://t.co/Ansx50r5UJ GWAs realizado en más de 320.000 paciente. Muy recomendable su lectura
@IntraMednet http://t.co/Ansx50r5UJ GWAs realizado en más de 320.000 paciente. Muy recomendable su lectura
Genetic studies of BMI yield new insights for #obesity biology http://t.co/GY3EB6aXh4 David Trégouët @ICAN_Institute/@INSERM/@UPMC in Nature
Genetic studies of body mass index yield new insights for obesity biology http://t.co/Z7nBLJ4kaX
肥満の遺伝要因についてより理解すべく、BMIについてゲノムワイド関連研究とMetabochipメタ解析を行った。結果、新規の座位56を含む97のBMI関連座位を特定し、パスウェイ解析では肥満感受性への中枢神経系の関与を裏付けた。 http://t.co/MCDy0YRXWu HA