↓ Skip to main content

Michigan Publishing

Article Metrics

Resting Functional Connectivity of the Periaqueductal Gray is Associated with Normal Inhibition and Pathological Facilitation in Conditioned Pain Modulation

Overview of attention for article published in Journal of Pain, January 2018
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#5 of 1,416)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
62 news outlets
twitter
10 tweeters

Citations

dimensions_citation
2 Dimensions

Readers on

mendeley
26 Mendeley
Title
Resting Functional Connectivity of the Periaqueductal Gray is Associated with Normal Inhibition and Pathological Facilitation in Conditioned Pain Modulation
Published in
Journal of Pain, January 2018
DOI 10.1016/j.jpain.2018.01.001
Pubmed ID
Authors

Daniel E. Harper, Eric Ichesco, Andrew Schrepf, Johnson P. Hampson, Daniel J. Clauw, Tobias Schmidt-Wilcke, Richard E. Harris, Steven E. Harte

Abstract

Conditioned pain modulation (CPM), a psychophysical paradigm that is commonly used to infer the integrity of endogenous pain-altering systems by observation of the effect of one noxious stimulus on another, has previously identified deficient endogenous analgesia in fibromyalgia (FM) and other chronic pain conditions. The mechanisms underlying this deficiency, be they insufficient inhibition and/or active facilitation, are largely unknown. The present cross sectional study used a combination of behavioral CPM testing, voxel based morphometry (VBM), and resting state functional connectivity to identify neural correlates of CPM in healthy controls (HC; n=14) and FM patients (n=15), and to probe for differences that could explain the pain-facilitative CPM that was observed in our patient sample. VBM identified a cluster encompassing the periaqueductal gray (PAG) that contained significantly less gray matter volume in FM patients. Higher resting connectivity between this cluster and cortical pain processing regions was associated with more efficient inhibitory CPM in both groups, whereas PAG connectivity with the dorsal pons was associated with greater CPM inhibition only in HC. Greater PAG connectivity to the caudal pons/rostral medulla, which was pain-inhibitory in HC, was associated with pain facilitation in FM. These findings indicate that variation in the strength of the PAG's resting functional connectivity can explain some of the normal variability in CPM. In addition, pain-facilitative CPM observed in FM patients likely involves both attenuation of pain inhibitory and amplification of pain facilitative processes in the central nervous system.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 35%
Student > Master 4 15%
Unspecified 3 12%
Student > Doctoral Student 3 12%
Professor 2 8%
Other 5 19%
Readers by discipline Count As %
Neuroscience 7 27%
Unspecified 6 23%
Medicine and Dentistry 4 15%
Nursing and Health Professions 3 12%
Engineering 3 12%
Other 3 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 496. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2018.
All research outputs
#12,883
of 11,794,606 outputs
Outputs from Journal of Pain
#5
of 1,416 outputs
Outputs of similar age
#872
of 309,742 outputs
Outputs of similar age from Journal of Pain
#1
of 52 outputs
Altmetric has tracked 11,794,606 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,416 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 309,742 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.