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Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA

Overview of attention for article published in Cell, December 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Readers on

mendeley
52 Mendeley
Title
Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA
Published in
Cell, December 2017
DOI 10.1016/j.cell.2017.11.040
Pubmed ID
Authors

Hosono, Yasuyuki, Niknafs, Yashar S., Prensner, John R., Iyer, Matthew K., Dhanasekaran, Saravana M., Mehra, Rohit, Pitchiaya, Sethuramasundaram, Tien, Jean, Escara-Wilke, June, Poliakov, Anton, Chu, Shih-Chun, Saleh, Sahal, Sankar, Keerthana, Su, Fengyun, Guo, Shuling, Qiao, Yuanyuan, Freier, Susan M., Bui, Huynh-Hoa, Cao, Xuhong, Malik, Rohit, Johnson, Timothy M., Beer, David G., Feng, Felix Y., Zhou, Weibin, Chinnaiyan, Arul M., Yasuyuki Hosono, Yashar S. Niknafs, John R. Prensner, Matthew K. Iyer, Saravana M. Dhanasekaran, Rohit Mehra, Sethuramasundaram Pitchiaya, Jean Tien, June Escara-Wilke, Anton Poliakov, Shih-Chun Chu, Sahal Saleh, Keerthana Sankar, Fengyun Su, Shuling Guo, Yuanyuan Qiao, Susan M. Freier, Huynh-Hoa Bui, Xuhong Cao, Rohit Malik, Timothy M. Johnson, David G. Beer, Felix Y. Feng, Weibin Zhou, Arul M. Chinnaiyan

Abstract

Large-scale transcriptome sequencing efforts have vastly expanded the catalog of long non-coding RNAs (lncRNAs) with varying evolutionary conservation, lineage expression, and cancer specificity. Here, we functionally characterize a novel ultraconserved lncRNA, THOR (ENSG00000226856), which exhibits expression exclusively in testis and a broad range of human cancers. THOR knockdown and overexpression in multiple cell lines and animal models alters cell or tumor growth supporting an oncogenic role. We discovered a conserved interaction of THOR with IGF2BP1 and show that THOR contributes to the mRNA stabilization activities of IGF2BP1. Notably, transgenic THOR knockout produced fertilization defects in zebrafish and also conferred a resistance to melanoma onset. Likewise, ectopic expression of human THOR in zebrafish accelerated the onset of melanoma. THOR represents a novel class of functionally important cancer/testis lncRNAs whose structure and function have undergone positive evolutionary selection.

Twitter Demographics

The data shown below were collected from the profiles of 82 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 38%
Researcher 13 25%
Student > Master 6 12%
Student > Bachelor 4 8%
Unspecified 3 6%
Other 6 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 19 37%
Agricultural and Biological Sciences 14 27%
Medicine and Dentistry 10 19%
Unspecified 4 8%
Immunology and Microbiology 4 8%
Other 1 2%

Attention Score in Context

This research output has an Altmetric Attention Score of 158. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2018.
All research outputs
#61,257
of 9,722,425 outputs
Outputs from Cell
#375
of 10,531 outputs
Outputs of similar age
#3,571
of 273,668 outputs
Outputs of similar age from Cell
#31
of 130 outputs
Altmetric has tracked 9,722,425 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,531 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,668 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 130 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.