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Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA

Overview of attention for article published in Cell, December 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)


13 Dimensions

Readers on

75 Mendeley
Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA
Published in
Cell, December 2017
DOI 10.1016/j.cell.2017.11.040
Pubmed ID

Hosono, Yasuyuki, Niknafs, Yashar S., Prensner, John R., Iyer, Matthew K., Dhanasekaran, Saravana M., Mehra, Rohit, Pitchiaya, Sethuramasundaram, Tien, Jean, Escara-Wilke, June, Poliakov, Anton, Chu, Shih-Chun, Saleh, Sahal, Sankar, Keerthana, Su, Fengyun, Guo, Shuling, Qiao, Yuanyuan, Freier, Susan M., Bui, Huynh-Hoa, Cao, Xuhong, Malik, Rohit, Johnson, Timothy M., Beer, David G., Feng, Felix Y., Zhou, Weibin, Chinnaiyan, Arul M., Yasuyuki Hosono, Yashar S. Niknafs, John R. Prensner, Matthew K. Iyer, Saravana M. Dhanasekaran, Rohit Mehra, Sethuramasundaram Pitchiaya, Jean Tien, June Escara-Wilke, Anton Poliakov, Shih-Chun Chu, Sahal Saleh, Keerthana Sankar, Fengyun Su, Shuling Guo, Yuanyuan Qiao, Susan M. Freier, Huynh-Hoa Bui, Xuhong Cao, Rohit Malik, Timothy M. Johnson, David G. Beer, Felix Y. Feng, Weibin Zhou, Arul M. Chinnaiyan


Large-scale transcriptome sequencing efforts have vastly expanded the catalog of long non-coding RNAs (lncRNAs) with varying evolutionary conservation, lineage expression, and cancer specificity. Here, we functionally characterize a novel ultraconserved lncRNA, THOR (ENSG00000226856), which exhibits expression exclusively in testis and a broad range of human cancers. THOR knockdown and overexpression in multiple cell lines and animal models alters cell or tumor growth supporting an oncogenic role. We discovered a conserved interaction of THOR with IGF2BP1 and show that THOR contributes to the mRNA stabilization activities of IGF2BP1. Notably, transgenic THOR knockout produced fertilization defects in zebrafish and also conferred a resistance to melanoma onset. Likewise, ectopic expression of human THOR in zebrafish accelerated the onset of melanoma. THOR represents a novel class of functionally important cancer/testis lncRNAs whose structure and function have undergone positive evolutionary selection.

Twitter Demographics

The data shown below were collected from the profiles of 76 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 75 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 31%
Researcher 17 23%
Student > Master 10 13%
Unspecified 8 11%
Student > Bachelor 7 9%
Other 10 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 30 40%
Agricultural and Biological Sciences 16 21%
Medicine and Dentistry 12 16%
Unspecified 11 15%
Immunology and Microbiology 4 5%
Other 2 3%

Attention Score in Context

This research output has an Altmetric Attention Score of 157. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2018.
All research outputs
of 11,467,888 outputs
Outputs from Cell
of 14,091 outputs
Outputs of similar age
of 299,264 outputs
Outputs of similar age from Cell
of 130 outputs
Altmetric has tracked 11,467,888 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,091 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.0. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,264 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 130 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.