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Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis

Overview of attention for article published in Nature Medicine, October 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
16 news outlets
blogs
1 blog
twitter
41 tweeters
facebook
9 Facebook pages

Citations

dimensions_citation
26 Dimensions

Readers on

mendeley
88 Mendeley
Title
Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis
Published in
Nature Medicine, October 2017
DOI 10.1038/nm.4412
Pubmed ID
Authors

Cen Xie, Tomoki Yagai, Yuhong Luo, Xianyi Liang, Tao Chen, Qiong Wang, Dongxue Sun, Jie Zhao, Sadeesh K Ramakrishnan, Lulu Sun, Chunmei Jiang, Xiang Xue, Yuan Tian, Kristopher W Krausz, Andrew D Patterson, Yatrik M Shah, Yue Wu, Changtao Jiang, Frank J Gonzalez

Abstract

Nonalcoholic fatty liver disease is becoming the most common chronic liver disease in Western countries, and limited therapeutic options are available. Here we uncovered a role for intestinal hypoxia-inducible factor (HIF) in hepatic steatosis. Human-intestine biopsies from individuals with or without obesity revealed that intestinal HIF-2α signaling was positively correlated with body-mass index and hepatic toxicity. The causality of this correlation was verified in mice with an intestine-specific disruption of Hif2a, in which high-fat-diet-induced hepatic steatosis and obesity were substantially lower as compared to control mice. PT2385, a HIF-2α-specific inhibitor, had preventive and therapeutic effects on metabolic disorders that were dependent on intestine HIF-2α. Intestine HIF-2α inhibition markedly reduced intestine and serum ceramide levels. Mechanistically, intestine HIF-2α regulates ceramide metabolism mainly from the salvage pathway, by positively regulating the expression of Neu3, the gene encoding neuraminidase 3. These results suggest that intestinal HIF-2α could be a viable target for hepatic steatosis therapy.

Twitter Demographics

The data shown below were collected from the profiles of 41 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 88 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 23 26%
Student > Ph. D. Student 22 25%
Student > Master 10 11%
Unspecified 9 10%
Student > Bachelor 7 8%
Other 17 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 23 26%
Medicine and Dentistry 18 20%
Unspecified 17 19%
Agricultural and Biological Sciences 13 15%
Immunology and Microbiology 6 7%
Other 11 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 158. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2019.
All research outputs
#91,596
of 13,635,685 outputs
Outputs from Nature Medicine
#309
of 6,679 outputs
Outputs of similar age
#3,941
of 274,318 outputs
Outputs of similar age from Nature Medicine
#6
of 61 outputs
Altmetric has tracked 13,635,685 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,679 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,318 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.