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Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multi-Site ENIGMA-PGC Study

Overview of attention for article published in Biological Psychiatry, September 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#21 of 2,100)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

26 news outlets
5 tweeters

Readers on

28 Mendeley
Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multi-Site ENIGMA-PGC Study
Published in
Biological Psychiatry, September 2017
DOI 10.1016/j.biopsych.2017.09.006
Pubmed ID

Logue, Mark W., van Rooij, Sanne J.H., Dennis, Emily L., Davis, Sarah L., Hayes, Jasmeet P., Stevens, Jennifer S., Densmore, Maria, Haswell, Courtney C., Ipser, Jonathan, Koch, Saskia B., Korgaonkar, Mayuresh, Lebois, Lauren A.M., Peverill, Matthew, Baker, Justin T., Boedhoe, Premika S.W., Frijling, Jessie L., Gruber, Staci A., Harpaz-Rotem, Ilan, Jahanshad, Neda, Koopowitz, Sheri, Levy, Ifat, Nawijn, Laura, O’Connor, Lauren, Olff, Miranda, Salat, David H., Sheridan, Margaret A., Spielberg, Jeffrey M., van Zuiden, Mirjam, Winternitz, Sherry R., Wolff, Jonathan D., Wolf, Erika J., Wang, Xin, Wrocklage, Kristen, Abdallah, Chadi G., Bryant, Richard A., Geuze, Elbert, Jovanovic, Tanja, Kaufman, Milissa L., King, Anthony P., Krystal, John H., Lagopoulos, Jim, Lanius, Ruth, Liberzon, Israel, McGlinchey, Regina E., McLaughlin, Katie A., Milberg, William P., Miller, Mark W., Ressler, Kerry J., Veltman, Dick J., Stein, Dan J., Thomaes, Kathleen, Thompson, Paul M., Morey, Rajendra A., Mark W. Logue, Sanne J.H. van Rooij, Emily L. Dennis, Sarah L. Davis, Jasmeet P. Hayes, Jennifer S. Stevens, Maria Densmore, Courtney C. Haswell, Jonathan Ipser, Saskia B. Koch, Mayuresh Korgaonkar, Lauren A.M. Lebois, Matthew Peverill, Justin T. Baker, Premika S.W. Boedhoe, Jessie L. Frijling, Staci A. Gruber, Ilan Harpaz-Rotem, Neda Jahanshad, Sheri Koopowitz, Ifat Levy, Laura Nawijn, Lauren O’Connor, Miranda Olff, David H. Salat, Margaret A. Sheridan, Jeffrey M. Spielberg, Mirjam van Zuiden, Sherry R. Winternitz, Jonathan D. Wolff, Erika J. Wolf, Xin Wang, Kristen Wrocklage, Chadi G. Abdallah, Richard A. Bryant, Elbert Geuze, Tanja Jovanovic, Milissa L. Kaufman, Anthony P. King, John H. Krystal, Jim Lagopoulos, Ruth Lanius, Israel Liberzon, Regina E. McGlinchey, Katie A. McLaughlin, William P. Milberg, Mark W. Miller, Kerry J. Ressler, Dick J. Veltman, Dan J. Stein, Kathleen Thomaes, Paul M. Thompson, Rajendra A. Morey, Saskia B.J. Koch, Maxwell Bennett


Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)-Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = -0.17, p = .00054), and smaller amygdalae (d = -0.11, p = .025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p < .0063). Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 25%
Researcher 6 21%
Unspecified 5 18%
Student > Master 4 14%
Student > Doctoral Student 2 7%
Other 4 14%
Readers by discipline Count As %
Unspecified 9 32%
Psychology 5 18%
Medicine and Dentistry 4 14%
Neuroscience 3 11%
Agricultural and Biological Sciences 2 7%
Other 5 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 198. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2018.
All research outputs
of 9,212,752 outputs
Outputs from Biological Psychiatry
of 2,100 outputs
Outputs of similar age
of 252,770 outputs
Outputs of similar age from Biological Psychiatry
of 61 outputs
Altmetric has tracked 9,212,752 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,100 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,770 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.