↓ Skip to main content

Michigan Publishing

Article Metrics

Incidence and outcomes of neonatal acute kidney injury (AWAKEN): a multicentre, multinational, observational cohort study

Overview of attention for article published in The Lancet Child & Adolescent Health, November 2017
Altmetric Badge

Mentioned by

blogs
1 blog
twitter
46 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
25 Dimensions

Readers on

mendeley
47 Mendeley
Title
Incidence and outcomes of neonatal acute kidney injury (AWAKEN): a multicentre, multinational, observational cohort study
Published in
The Lancet Child & Adolescent Health, November 2017
DOI 10.1016/s2352-4642(17)30069-x
Pubmed ID
Authors

Jennifer G Jetton, Louis J Boohaker, Sidharth K Sethi, Sanjay Wazir, Smriti Rohatgi, Danielle E Soranno, Aftab S Chishti, Robert Woroniecki, Cherry Mammen, Jonathan R Swanson, Shanthy Sridhar, Craig S Wong, Juan C Kupferman, Russell L Griffin, David J Askenazi, David T Selewski, Subrata Sarkar, Alison Kent, Jeffery Fletcher, Carolyn L Abitbol, Marissa DeFreitas, Shahnaz Duara, Jennifer R Charlton, Ronnie Guillet, Carl D'Angio, Ayesa Mian, Erin Rademacher, Maroun J Mhanna, Rupesh Raina, Deepak Kumar, Namasivayam Ambalavanan, Ayse Akcan Arikan, Christopher J Rhee, Stuart L Goldstein, Amy T Nathan, Alok Bhutada, Shantanu Rastogi, Elizabeth Bonachea, Susan Ingraham, John Mahan, Arwa Nada, Patrick D Brophy, Tarah T Colaizy, Jonathan M Klein, F Sessions Cole, T Keefe Davis, Joshua Dower, Lawrence Milner, Alexandra Smith, Mamta Fuloria, Kimberly Reidy, Frederick J Kaskel, Jason Gien, Katja M Gist, Mina H Hanna, Sangeeta Hingorani, Michelle Starr, Catherine Joseph, Tara DuPont, Robin Ohls, Amy Staples, Surender Khokhar, Sofia Perazzo, Patricio E Ray, Mary Revenis, Anne Synnes, Pia Wintermark

Abstract

Single-center studies suggest that neonatal acute kidney injury (AKI) is associated with poor outcomes. However, inferences regarding the association between AKI, mortality, and hospital length of stay are limited due to the small sample size of those studies. In order to determine whether neonatal AKI is independently associated with increased mortality and longer hospital stay, we analyzed the Assessment of Worldwide Acute Kidney Epidemiology in Neonates (AWAKEN) database. All neonates admitted to 24 participating neonatal intensive care units from four countries (Australia, Canada, India, United States) between January 1 and March 31, 2014, were screened. Of 4273 neonates screened, 2022 (47·3%) met study criteria. Exclusion criteria included: no intravenous fluids ≥48 hours, admission ≥14 days of life, congenital heart disease requiring surgical repair at <7 days of life, lethal chromosomal anomaly, death within 48 hours, inability to determine AKI status or severe congenital kidney abnormalities. AKI was defined using a standardized definition -i.e., serum creatinine rise of ≥0.3 mg/dL (26.5 mcmol/L) or ≥50% from previous lowest value, and/or if urine output was <1 mL/kg/h on postnatal days 2 to 7. Incidence of AKI was 605/2022 (29·9%). Rates varied by gestational age groups (i.e., ≥22 to <29 weeks =47·9%; ≥29 to <36 weeks =18·3%; and ≥36 weeks =36·7%). Even after adjusting for multiple potential confounding factors, infants with AKI had higher mortality compared to those without AKI [(59/605 (9·7%) vs. 20/1417 (1·4%); p< 0.001; adjusted OR=4·6 (95% CI=2·5-8·3); p=<0·0001], and longer hospital stay [adjusted parameter estimate 8·8 days (95% CI=6·1-11·5); p<0·0001]. Neonatal AKI is a common and independent risk factor for mortality and longer hospital stay. These data suggest that neonates may be impacted by AKI in a manner similar to pediatric and adult patients. US National Institutes of Health, University of Alabama at Birmingham, Cincinnati Children's, University of New Mexico.

Twitter Demographics

The data shown below were collected from the profiles of 46 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 12 26%
Researcher 10 21%
Professor > Associate Professor 9 19%
Other 7 15%
Student > Postgraduate 5 11%
Other 4 9%
Readers by discipline Count As %
Medicine and Dentistry 28 60%
Unspecified 16 34%
Nursing and Health Professions 2 4%
Engineering 1 2%