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Glucagon Regulates Hepatic Kisspeptin to Impair Insulin Secretion

Overview of attention for article published in Cell Metabolism (Science Direct), April 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Citations

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73 Dimensions

Readers on

mendeley
88 Mendeley
Title
Glucagon Regulates Hepatic Kisspeptin to Impair Insulin Secretion
Published in
Cell Metabolism (Science Direct), April 2014
DOI 10.1016/j.cmet.2014.03.005
Pubmed ID
Authors

Woo-Jin Song, Prosenjit Mondal, Andrew Wolfe, Laura C. Alonso, Rachel Stamateris, Benny W.T. Ong, Owen C. Lim, Kil S. Yang, Sally Radovick, Horacio J. Novaira, Emily A. Farber, Charles R. Farber, Stephen D. Turner, Mehboob A. Hussain

Abstract

Early in the pathogenesis of type 2 diabetes mellitus (T2DM), dysregulated glucagon secretion from pancreatic α cells occurs prior to impaired glucose-stimulated insulin secretion (GSIS) from β cells. However, whether hyperglucagonemia is causally linked to β cell dysfunction remains unclear. Here we show that glucagon stimulates via cAMP-PKA-CREB signaling hepatic production of the neuropeptide kisspeptin1, which acts on β cells to suppress GSIS. Synthetic kisspeptin suppresses GSIS in vivo in mice and from isolated islets in a kisspeptin1 receptor-dependent manner. Kisspeptin1 is increased in livers and in serum from humans with T2DM and from mouse models of diabetes mellitus. Importantly, liver Kiss1 knockdown in hyperglucagonemic, glucose-intolerant, high-fat-diet fed, and Lepr(db/db) mice augments GSIS and improves glucose tolerance. These observations indicate a hormonal circuit between the liver and the endocrine pancreas in glycemia regulation and suggest in T2DM a sequential link between hyperglucagonemia via hepatic kisspeptin1 to impaired insulin secretion.

Twitter Demographics

The data shown below were collected from the profiles of 25 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 1%
Mexico 1 1%
Brazil 1 1%
Japan 1 1%
Sweden 1 1%
Unknown 83 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 22%
Researcher 16 18%
Student > Master 16 18%
Student > Bachelor 9 10%
Professor 8 9%
Other 20 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 39 44%
Medicine and Dentistry 22 25%
Biochemistry, Genetics and Molecular Biology 14 16%
Unspecified 5 6%
Immunology and Microbiology 1 1%
Other 7 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2018.
All research outputs
#362,278
of 11,877,920 outputs
Outputs from Cell Metabolism (Science Direct)
#417
of 1,959 outputs
Outputs of similar age
#7,516
of 187,833 outputs
Outputs of similar age from Cell Metabolism (Science Direct)
#12
of 46 outputs
Altmetric has tracked 11,877,920 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,959 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 45.1. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 187,833 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.