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Mitochondrial function as a therapeutic target in heart failure

Overview of attention for article published in Nature Reviews Cardiology, December 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#12 of 1,249)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
6 news outlets
twitter
80 tweeters
facebook
16 Facebook pages

Citations

dimensions_citation
124 Dimensions

Readers on

mendeley
275 Mendeley
Title
Mitochondrial function as a therapeutic target in heart failure
Published in
Nature Reviews Cardiology, December 2016
DOI 10.1038/nrcardio.2016.203
Pubmed ID
Authors

David A. Brown, Justin B. Perry, Mitchell E. Allen, Hani N. Sabbah, Brian L. Stauffer, Saame Raza Shaikh, John G. F. Cleland, Wilson S. Colucci, Javed Butler, Adriaan A. Voors, Stefan D. Anker, Bertram Pitt, Burkert Pieske, Gerasimos Filippatos, Stephen J. Greene, Mihai Gheorghiade

Abstract

Heart failure is a pressing worldwide public-health problem with millions of patients having worsening heart failure. Despite all the available therapies, the condition carries a very poor prognosis. Existing therapies provide symptomatic and clinical benefit, but do not fully address molecular abnormalities that occur in cardiomyocytes. This shortcoming is particularly important given that most patients with heart failure have viable dysfunctional myocardium, in which an improvement or normalization of function might be possible. Although the pathophysiology of heart failure is complex, mitochondrial dysfunction seems to be an important target for therapy to improve cardiac function directly. Mitochondrial abnormalities include impaired mitochondrial electron transport chain activity, increased formation of reactive oxygen species, shifted metabolic substrate utilization, aberrant mitochondrial dynamics, and altered ion homeostasis. In this Consensus Statement, insights into the mechanisms of mitochondrial dysfunction in heart failure are presented, along with an overview of emerging treatments with the potential to improve the function of the failing heart by targeting mitochondria.

Twitter Demographics

The data shown below were collected from the profiles of 80 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 275 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Spain 1 <1%
Unknown 272 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 60 22%
Researcher 59 21%
Unspecified 42 15%
Student > Bachelor 28 10%
Student > Master 23 8%
Other 63 23%
Readers by discipline Count As %
Medicine and Dentistry 64 23%
Agricultural and Biological Sciences 59 21%
Biochemistry, Genetics and Molecular Biology 58 21%
Unspecified 56 20%
Pharmacology, Toxicology and Pharmaceutical Science 8 3%
Other 30 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 93. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2019.
All research outputs
#172,376
of 13,401,937 outputs
Outputs from Nature Reviews Cardiology
#12
of 1,249 outputs
Outputs of similar age
#8,407
of 371,882 outputs
Outputs of similar age from Nature Reviews Cardiology
#1
of 36 outputs
Altmetric has tracked 13,401,937 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,249 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 371,882 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.