RT @medical_xpress: Researchers use a new approach to hit an 'undruggable' target @umich @nchembio https://t.co/fqmBtBREi7 https://t.co/o5E…
ICYMI: New from Shaomeng Wang lab: A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo: Read the paper in @nchembio: https://t.co/2QHYAMZSx6 Read the summary: https://t.co/qumd4yGJ20
RT @medical_xpress: Researchers use a new approach to hit an 'undruggable' target @umich @nchembio https://t.co/fqmBtBREi7 https://t.co/o5E…
AK-2292 is a first, potent and selective small-molecule degrader of both STAT5A and STAT5B isoforms. https://t.co/U1tLVXITAe
RT @UMRogelCancer: Researchers led by Shaomeng Wang use protein degrader to eliminate STAT5. Findings are promising in cell cultures and mi…
RT @UMRogelCancer: Researchers led by Shaomeng Wang use protein degrader to eliminate STAT5. Findings are promising in cell cultures and mi…
Researchers led by Shaomeng Wang use protein degrader to eliminate STAT5. Findings are promising in cell cultures and mice, setting the stage for potential drug development. Read the paper in @nchembio: https://t.co/2QHYAN0qmE Read the summary: https://t
RT @medical_xpress: Researchers use a new approach to hit an 'undruggable' target @umich @nchembio https://t.co/fqmBtBREi7 https://t.co/o5E…
A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo https://t.co/0fJcphyEEw
RT @medical_xpress: Researchers use a new approach to hit an 'undruggable' target @umich @nchembio https://t.co/fqmBtBREi7 https://t.co/o5E…
RT @medical_xpress: Researchers use a new approach to hit an 'undruggable' target @umich @nchembio https://t.co/fqmBtBREi7 https://t.co/o5E…
RT @medical_xpress: Researchers use a new approach to hit an 'undruggable' target @umich @nchembio https://t.co/fqmBtBREi7 https://t.co/o5E…
RT @medical_xpress: Researchers use a new approach to hit an 'undruggable' target @umich @nchembio https://t.co/fqmBtBREi7 https://t.co/o5E…
Researchers use a new approach to hit an 'undruggable' target @umich @nchembio https://t.co/fqmBtBREi7 https://t.co/o5EhsxU59F
RT @nchembio: A new paper from Shaomeng Wang and colleagues developed a potent and selective PROTAC degrader that depletes STAT5 in cells a…
RT @UMLifeSciences: A collaboration between @UMichPharmacy, @UMRogelCancer, @UMIntMed, and the Center for Structural Biology developed a po…
RT @UMLifeSciences: A collaboration between @UMichPharmacy, @UMRogelCancer, @UMIntMed, and the Center for Structural Biology developed a po…
RT @KRHornberger: STAT5 degraders, with in vivo proof of principle. +1 for proper PK/ADME workup, even though it’s stuck in the SI. Degradi…
RT @KRHornberger: STAT5 degraders, with in vivo proof of principle. +1 for proper PK/ADME workup, even though it’s stuck in the SI. Degradi…
RT @UMLifeSciences: A collaboration between @UMichPharmacy, @UMRogelCancer, @UMIntMed, and the Center for Structural Biology developed a po…
RT @UMLifeSciences: A collaboration between @UMichPharmacy, @UMRogelCancer, @UMIntMed, and the Center for Structural Biology developed a po…
RT @KRHornberger: STAT5 degraders, with in vivo proof of principle. +1 for proper PK/ADME workup, even though it’s stuck in the SI. Degradi…
RT @KRHornberger: STAT5 degraders, with in vivo proof of principle. +1 for proper PK/ADME workup, even though it’s stuck in the SI. Degradi…
RT @KRHornberger: STAT5 degraders, with in vivo proof of principle. +1 for proper PK/ADME workup, even though it’s stuck in the SI. Degradi…
STAT5A/5Bを選択的に分解するPROTAC, AK-2292の開発。他のSTATおよび6,000以上の非STATタンパク質に対して選択的。正常マウス組織およびヒト慢性骨髄性白血病(CML)異種移植組織においてSTAT5枯渇を効果的に誘導し、2つのCML異種移植マウスモデルにおいて腫瘍退縮を達成。 https://t.co/BcordYtOI5
RT @KRHornberger: STAT5 degraders, with in vivo proof of principle. +1 for proper PK/ADME workup, even though it’s stuck in the SI. Degradi…
RT @KRHornberger: STAT5 degraders, with in vivo proof of principle. +1 for proper PK/ADME workup, even though it’s stuck in the SI. Degradi…
RT @KRHornberger: STAT5 degraders, with in vivo proof of principle. +1 for proper PK/ADME workup, even though it’s stuck in the SI. Degradi…
STAT5 degraders, with in vivo proof of principle. +1 for proper PK/ADME workup, even though it’s stuck in the SI. Degrading transcription factors slowly starting to be a thing. https://t.co/ntBuZQaiGw
RT @nchembio: A new paper from Shaomeng Wang and colleagues developed a potent and selective PROTAC degrader that depletes STAT5 in cells a…
RT @nchembio: A new paper from Shaomeng Wang and colleagues developed a potent and selective PROTAC degrader that depletes STAT5 in cells a…
RT @ghostbnh: A selective small-molecule #STAT5 PROTAC degrader capable of achieving tumor regression in vivo https://t.co/AsbHMdipJw
Exciting new work from @UMPharmacology Dr. Shaomeng Wang's group: A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo https://t.co/sh8ltnJn7j
RT @Trankill34: A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo | @nchembio https://t.co/1Ww…
RT @Trankill34: A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo | @nchembio https://t.co/1Ww…
RT @nchembio: A new paper from Shaomeng Wang and colleagues developed a potent and selective PROTAC degrader that depletes STAT5 in cells a…
RT @nchembio: A new paper from Shaomeng Wang and colleagues developed a potent and selective PROTAC degrader that depletes STAT5 in cells a…
A selective smallmolecule STAT5 PROTAC degrader capable of achieving tumor regression in null https://t.co/OAmAYuH4b2 #DTHSTR
RT @UMLifeSciences: A collaboration between @UMichPharmacy, @UMRogelCancer, @UMIntMed, and the Center for Structural Biology developed a po…
RT @nchembio: A new paper from Shaomeng Wang and colleagues developed a potent and selective PROTAC degrader that depletes STAT5 in cells a…
RT @UMLifeSciences: A collaboration between @UMichPharmacy, @UMRogelCancer, @UMIntMed, and the Center for Structural Biology developed a po…
A selective small-molecule #STAT5 #PROTAC #degrader capable of achieving tumor regression in vivo | Nature Chemical Biology https://t.co/lgxDmimQjh
RT @UMLifeSciences: A collaboration between @UMichPharmacy, @UMRogelCancer, @UMIntMed, and the Center for Structural Biology developed a po…
RT @UMLifeSciences: A collaboration between @UMichPharmacy, @UMRogelCancer, @UMIntMed, and the Center for Structural Biology developed a po…
RT @UMLifeSciences: A collaboration between @UMichPharmacy, @UMRogelCancer, @UMIntMed, and the Center for Structural Biology developed a po…
A collaboration between @UMichPharmacy, @UMRogelCancer, @UMIntMed, and the Center for Structural Biology developed a potent small-molecule STAT5 PROTAC degrader. It shows promise a both a research tool and a driver of tumor regression in mouse models. htt
RT @nchembio: A new paper from Shaomeng Wang and colleagues developed a potent and selective PROTAC degrader that depletes STAT5 in cells a…
RT @nchembio: A new paper from Shaomeng Wang and colleagues developed a potent and selective PROTAC degrader that depletes STAT5 in cells a…
RT @ghostbnh: A selective small-molecule #STAT5 PROTAC degrader capable of achieving tumor regression in vivo https://t.co/AsbHMdipJw
RT @Trankill34: A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo | @nchembio https://t.co/1Ww…
A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo | @nchembio https://t.co/1WwdYt2Ky1
RT @nchembio: A new paper from Shaomeng Wang and colleagues developed a potent and selective PROTAC degrader that depletes STAT5 in cells a…
A selective small-molecule #STAT5 PROTAC degrader capable of achieving tumor regression in vivo https://t.co/AsbHMdipJw
RT @nchembio: A new paper from Shaomeng Wang and colleagues developed a potent and selective PROTAC degrader that depletes STAT5 in cells a…
A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo | Nature Chemical Biology https://t.co/gisDASUftd
A new paper from Shaomeng Wang and colleagues developed a potent and selective PROTAC degrader that depletes STAT5 in cells and induces tumor regression in mouse models. Free to read: https://t.co/4vTNDnI9kW https://t.co/mVtcXR1bpG