RT @XianyongYin: Glad our paper is highlighted by IGES @genepisociety. Thanks to collaborators @Eric_Fauman @klmohlke and many others not o…

I put CERS6 on Chr2 in italics because it is not actually in the EGEA. Not for lack of evidence but because we didn't report that locus in Yin et al because while it reached genome-wide significance (5e-8) it didn't reach study-wide significance (7.2e-11).

So this hit for glycerol-3-phosphate at GPD2 wasn't reported in Yin et al. But is it real? https://t.co/kg0hv9nxEa

This GWAS comes from the METSIM genetics metabolomics study of 1391 metabolites in 6136 men. Because of the large number of endpoints we set a significance threshold of 7.2e-11. This GWAS only gets to 6.7e-9: "genome wide significant" but not "study wide"

Including 1,610 associations from Yin et al METSIM metabolon study! https://t.co/kg0hv9EAGa Here's a quick way to find the strongest association in the study: https://t.co/w2Uq6UH9Uf and sort on p-value

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

I would not forget this one: https://t.co/m1yA6BkMla .. wasn't this the start of it?

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

RT @Eric_Fauman: What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.c…

What do these 3 papers have in common? https://t.co/tUvZqL9Kfp https://t.co/kg0hv9mZOC https://t.co/ndea23R7Le https://t.co/XK6hA0CFAa

The 2 hits in this plot were not reported in our 2022 METSIM metabolon paper This is because while they reached a standard genome-wide significance cutoff of 5e-8, we were studying 1391 metabolites so we applied a stricter cutoff of 7e-11 https://t.co/kg0

@skathire Is Verve looking for more targets? https://t.co/ItPWkUYpQ0

RT @Eric_Fauman: Here I highlighted all of the relevant GWAS gene-metabolite associations identified in our METSIM study https://t.co/DFyf7…

RT @Eric_Fauman: Here I highlighted all of the relevant GWAS gene-metabolite associations identified in our METSIM study https://t.co/DFyf7…

Here I highlighted all of the relevant GWAS gene-metabolite associations identified in our METSIM study https://t.co/DFyf7QDqzr superimposed on known biochemical pathways, derived from: https://t.co/2uOaqkg6D6 Ovals are the known links, genes in color are

RT @genepisociety: The IGES paper highlight for March 2022 is by Yin et al. They report 303 new genetic associations with 1391 circulatin…

RT @genepisociety: The IGES paper highlight for March 2022 is by Yin et al. They report 303 new genetic associations with 1391 circulatin…

Glad our paper is highlighted by IGES @genepisociety. Thanks to collaborators @Eric_Fauman @klmohlke and many others not on twitter

RT @genepisociety: The IGES paper highlight for March 2022 is by Yin et al. They report 303 new genetic associations with 1391 circulatin…

The IGES paper highlight for March 2022 is by Yin et al. They report 303 new genetic associations with 1391 circulating metabolites in 6136 Finnish men. They demonstrate that metabolite genetic associations can help elucidate disease mechanisms https://

RT @Eric_Fauman: For our METSIM @metabolon GWAS I manually annotated all 2000 of our lead associations. From the supplementary table,…

RT @Eric_Fauman: For our METSIM @metabolon GWAS I manually annotated all 2000 of our lead associations. From the supplementary table,…

For our METSIM @metabolon GWAS I manually annotated all 2000 of our lead associations. From the supplementary table, here are all the associations I linked to PYROXD2. The strongest is N6-methyllysine, at a p-value of 8e-2182! https://t.co/DFyf7QDqz

RT @Eric_Fauman: Another data point in the exploration of how best to incorporate eQTL information in GWAS interpretation. GWAS of 9-hydro…

RT @Eric_Fauman: Another data point in the exploration of how best to incorporate eQTL information in GWAS interpretation. GWAS of 9-hydro…

RT @Eric_Fauman: Another data point in the exploration of how best to incorporate eQTL information in GWAS interpretation. GWAS of 9-hydro…

RT @Eric_Fauman: Another data point in the exploration of how best to incorporate eQTL information in GWAS interpretation. GWAS of 9-hydro…

RT @Eric_Fauman: Another data point in the exploration of how best to incorporate eQTL information in GWAS interpretation. GWAS of 9-hydro…

RT @Eric_Fauman: Another data point in the exploration of how best to incorporate eQTL information in GWAS interpretation. GWAS of 9-hydro…

RT @Eric_Fauman: Another data point in the exploration of how best to incorporate eQTL information in GWAS interpretation. GWAS of 9-hydro…

Another data point in the exploration of how best to incorporate eQTL information in GWAS interpretation. GWAS of 9-hydroxystearate in METSIM https://t.co/DFyf7QDqzr

RT @Eric_Fauman: Happy Saturday! I'm taking this opportunity to catch up on this metabolite GWAS from @SbotGwa from our METSIM GWAS https…

RT @Eric_Fauman: Happy Saturday! I'm taking this opportunity to catch up on this metabolite GWAS from @SbotGwa from our METSIM GWAS https…

RT @Eric_Fauman: Happy Saturday! I'm taking this opportunity to catch up on this metabolite GWAS from @SbotGwa from our METSIM GWAS https…

RT @Eric_Fauman: Happy Saturday! I'm taking this opportunity to catch up on this metabolite GWAS from @SbotGwa from our METSIM GWAS https…

RT @Eric_Fauman: @RuxandraTesloi1 @SbotGwa Well then you're in for a treat! https://t.co/DFyf7QDqzr

RT @Eric_Fauman: Happy Saturday! I'm taking this opportunity to catch up on this metabolite GWAS from @SbotGwa from our METSIM GWAS https…

RT @Eric_Fauman: Happy Saturday! I'm taking this opportunity to catch up on this metabolite GWAS from @SbotGwa from our METSIM GWAS https…

RT @Eric_Fauman: Happy Saturday! I'm taking this opportunity to catch up on this metabolite GWAS from @SbotGwa from our METSIM GWAS https…

RT @Eric_Fauman: Happy Saturday! I'm taking this opportunity to catch up on this metabolite GWAS from @SbotGwa from our METSIM GWAS https…

@RuxandraTesloi1 @SbotGwa Well then you're in for a treat! https://t.co/DFyf7QDqzr

Happy Saturday! I'm taking this opportunity to catch up on this metabolite GWAS from @SbotGwa from our METSIM GWAS https://t.co/kg0hv9mZOC One hit for "2-palmitoyl-GPE (16:0)" What does this mean? https://t.co/9LgXjIp6Cz

This Manhattan plot for N-formylanthranilic acid. This comes from our METSIM metabolon GWAS This represents the strongest association ever seen for this metabolite and the strongest association ever reported for the AFMID locus. https://t.co/b2pBvNGaA2 ht

RT @Eric_Fauman: Ok, so what did we learn about hydroxylysine genetics from our METSIM GWAS? Note the single locus for hydroxylysine (top)…

@SbotGwa So delighted to see our METSIM @Metabolon in the @sbotgwa rotation! https://t.co/kg0hv9mZOC with Xianyong Yin, Markku Laakso & Michael Boehnke

Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci https://t.co/A9ROvQ32Xi

RT @Eric_Fauman: Time for another METSIM-inspired game of “who’s that causal gene?”, featuring the Twitter-debut of an enzyme as old as lif…

RT @Eric_Fauman: Time for another METSIM-inspired game of “who’s that causal gene?”, featuring the Twitter-debut of an enzyme as old as lif…

RT @Eric_Fauman: Time for another METSIM-inspired game of “who’s that causal gene?”, featuring the Twitter-debut of an enzyme as old as lif…

RT @Eric_Fauman: Time for another METSIM-inspired game of “who’s that causal gene?”, featuring the Twitter-debut of an enzyme as old as lif…

RT @Eric_Fauman: Time for another METSIM-inspired game of “who’s that causal gene?”, featuring the Twitter-debut of an enzyme as old as lif…

RT @Eric_Fauman: Time for another METSIM-inspired game of “who’s that causal gene?”, featuring the Twitter-debut of an enzyme as old as lif…

Time for another METSIM-inspired game of “who’s that causal gene?”, featuring the Twitter-debut of an enzyme as old as life itself https://t.co/kg0hv9mZOC https://t.co/mmlHETfDTV

RT @Eric_Fauman: Ok, so what did we learn about hydroxylysine genetics from our METSIM GWAS? Note the single locus for hydroxylysine (top)…

@samiinkinen FINLAND for the win!!???? biochemistry ? Hard field however physics is not a picnic either! @virtahealth rest & renew....! I did telephonic disease management when I was much younger. Remember to exercise daily! Sharpen your saw: YOU!

RT @Eric_Fauman: Time for another METSIM-inspired installment of “who’s that causal gene?” This one involves: 1) the most abundant animal…

RT @Eric_Fauman: Time for another METSIM-inspired installment of “who’s that causal gene?” This one involves: 1) the most abundant animal…

RT @Eric_Fauman: Time for another METSIM-inspired installment of “who’s that causal gene?” This one involves: 1) the most abundant animal…

RT @Eric_Fauman: Time for another METSIM-inspired installment of “who’s that causal gene?” This one involves: 1) the most abundant animal…

RT @Eric_Fauman: Time for another METSIM-inspired installment of “who’s that causal gene?” This one involves: 1) the most abundant animal…

RT @Eric_Fauman: Time for another METSIM-inspired installment of “who’s that causal gene?” This one involves: 1) the most abundant animal…

RT @Eric_Fauman: Time for another METSIM-inspired installment of “who’s that causal gene?” This one involves: 1) the most abundant animal…

Ok, so what did we learn about hydroxylysine genetics from our METSIM GWAS? Note the single locus for hydroxylysine (top) is completely independent from any of the loci for lysine (bottom)! (please check out the awesome pheweb site) https://t.co/KeMS3JUV1H

Time for another METSIM-inspired installment of “who’s that causal gene?” This one involves: 1) the most abundant animal protein in the world, 2) some unusual metabolites, 3) and some impossibly bad pseudoscience! https://t.co/kg0hv9mZOC https://t.c

@MayMontasser @CommsBio Metabolomics in a founder population you say? I hope you saw our paper last week on metabolomics GWAS in a Finnish population: https://t.co/kg0hv9mZOC

RT @Eric_Fauman: Another gene story from the METSIM metabolite GWAS archives: https://t.co/kg0hv9mZOC https://t.co/md7OHbud1N

RT @Eric_Fauman: Another gene story from the METSIM metabolite GWAS archives: https://t.co/kg0hv9mZOC https://t.co/md7OHbud1N

RT @Eric_Fauman: Another gene story from the METSIM metabolite GWAS archives: https://t.co/kg0hv9mZOC https://t.co/md7OHbud1N

@andrewhicks Just so this not all for naught I have a story over here about the 2nd closest gene being the causal gene: https://t.co/35Ytl6866e

RT @Eric_Fauman: Another gene story from the METSIM metabolite GWAS archives: https://t.co/kg0hv9mZOC https://t.co/md7OHbud1N

RT @Eric_Fauman: Another gene story from the METSIM metabolite GWAS archives: https://t.co/kg0hv9mZOC https://t.co/md7OHbud1N

Another gene story from the METSIM metabolite GWAS archives: https://t.co/kg0hv9mZOC https://t.co/md7OHbud1N

RT @NatureComms: Yin et al. find new genetic loci associated with 1391 circulating metabolites in 6136 Finnish men, demonstrating that meta…