RT @TweetALSMND: #ICYMI SRSF1 may contribute to #C9orf72 #ALS by helping to export repeat-rich RNAs. Could targeting SRPK1 block this proc…
#ICYMI SRSF1 may contribute to #C9orf72 #ALS by helping to export repeat-rich RNAs. Could targeting SRPK1 block this process, thereby reducing neurotoxicity? @realToddLab SRSF protein kinase 1 modulates #RANtranslation and suppresses CGG repeat toxicity
RT @realToddLab: Ever wonder if the RNA binding proteins that bind repeat RNAs are the same in cells as they are in vitro? @IndranilMalik…
RT @realToddLab: Ever wonder if the RNA binding proteins that bind repeat RNAs are the same in cells as they are in vitro? @IndranilMalik…
RT @realToddLab: Ever wonder if the RNA binding proteins that bind repeat RNAs are the same in cells as they are in vitro? @IndranilMalik…
RT @EmboMolMed: New study identifies CGG repeat #RNAbindingproteins and their kinases as regulators of repeat associated non-AUG (RAN) tran…
RT @realToddLab: Ever wonder if the RNA binding proteins that bind repeat RNAs are the same in cells as they are in vitro? @IndranilMalik…
RT @realToddLab: Ever wonder if the RNA binding proteins that bind repeat RNAs are the same in cells as they are in vitro? @IndranilMalik…
RT @realToddLab: Ever wonder if the RNA binding proteins that bind repeat RNAs are the same in cells as they are in vitro? @IndranilMalik…
RT @realToddLab: Ever wonder if the RNA binding proteins that bind repeat RNAs are the same in cells as they are in vitro? @IndranilMalik…
RT @realToddLab: Ever wonder if the RNA binding proteins that bind repeat RNAs are the same in cells as they are in vitro? @IndranilMalik…
New article: SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity https://t.co/tptSyAAusj #alzheimers #neurology https://t.co/SmuamjCyuO
RT @realToddLab: Ever wonder if the RNA binding proteins that bind repeat RNAs are the same in cells as they are in vitro? @IndranilMalik…
New study identifies CGG repeat #RNAbindingproteins and their kinases as regulators of repeat associated non-AUG (RAN) translation and #neurotoxicity. #FXTAS #FragileX By I. Malik, P. Todd & colleagues @UMich -> Read #openaccess: https://t.co/3xMt
I have always wondered!!
RT @realToddLab: Ever wonder if the RNA binding proteins that bind repeat RNAs are the same in cells as they are in vitro? @IndranilMalik…
Intriguingly, SRPK1 inhibitors and genetic modifiers enhance neuronal survival in two models of FXTAS and in ALS model flies. Shoutout to @s8282lulu and Shannon Wright + @BarmadaLab for help with neuronal survival. https://t.co/xZWfhUmrCr
@IndranilMalik then found that inhibiting the SR protein Kinase SRPK1 suppressed RAN translation for CGG repeats that cause FXTAS and for G4C2 repeats that cause ALS both directly and by impairin RNA nuclear export. 3/ https://t.co/xZWfhUmrCr
RT @realToddLab: Ever wonder if the RNA binding proteins that bind repeat RNAs are the same in cells as they are in vitro? @IndranilMalik…
RT @realToddLab: Ever wonder if the RNA binding proteins that bind repeat RNAs are the same in cells as they are in vitro? @IndranilMalik…
He found that SRSF proteins were highly enriched CGG repeat binders and their knockdown suppressed toxicity in flies. 2/ https://t.co/oKOHwuMeVb
Ever wonder if the RNA binding proteins that bind repeat RNAs are the same in cells as they are in vitro? @IndranilMalik used a creative in-cell RNA Repeat capture technique to pull out new CGG RNA repeat binding proteins. 1/ https://t.co/QN9RS8ixZu