Small molecule inhibitors to epigenetic enzymes are crucial for probing mechanisms and developing new therapeutics. Grembecka and Cierpicki labs @UMichPath developed a novel PRC1 inhibitor - characterized using EpiCypher nucleosome substrates! https://t.co
RT @NatRevClinOncol: Emerging evidence implicates PRC1 activity in various cancers; compounds that directly bind to RING1B–BMI1, the comple…
RT @NatRevClinOncol: Emerging evidence implicates PRC1 activity in various cancers; compounds that directly bind to RING1B–BMI1, the comple…
RT @NatRevClinOncol: Emerging evidence implicates PRC1 activity in various cancers; compounds that directly bind to RING1B–BMI1, the comple…
RT @NatRevClinOncol: Emerging evidence implicates PRC1 activity in various cancers; compounds that directly bind to RING1B–BMI1, the comple…
Emerging evidence implicates PRC1 activity in various cancers; compounds that directly bind to RING1B–BMI1, the complex constituting the E3 ligase activity of PRC1, decrease global repressive H2A mono-ubiquitination & induce differentiation in AML cell
RT @nchembio: A new paper reports small molecule inhibitors of polycomb repressive complex 1 that target the RING domain of E3 ligase RING1…
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain #lymphoma #lymsm https://t.co/sh21B7FAuS
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain https://t.co/IahQo9ETq2 https://t.co/JoAgGVpL2F
New article: Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain https://t.co/GbAXujEsuf #AML #leusm #hematology https://t.co/crPodgqEaw
RT @nchembio: A new paper reports small molecule inhibitors of polycomb repressive complex 1 that target the RING domain of E3 ligase RING1…
RT @nchembio: A new paper reports small molecule inhibitors of polycomb repressive complex 1 that target the RING domain of E3 ligase RING1…
RT @nchembio: A new paper reports small molecule inhibitors of polycomb repressive complex 1 that target the RING domain of E3 ligase RING1…
Just out from the labs of #RogelCancer's Drs. Tomasz Cierpicki & Jolanta Grembecka!
Glad to see our work online!
A new paper reports small molecule inhibitors of polycomb repressive complex 1 that target the RING domain of E3 ligase RING1B-BMI1. Free to read: https://t.co/g1jnvigBlB https://t.co/ibwE71wpKn
Read the study: https://t.co/TWoeWLcCvl
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain https://t.co/Veg6icTwgg https://t.co/Ck532AxZkB