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Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome

Overview of attention for article published in JAMA Neurology, March 2021
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#11 of 2,502)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
44 news outlets
blogs
1 blog
twitter
1064 tweeters
facebook
2 Facebook pages
wikipedia
1 Wikipedia page
reddit
2 Redditors

Readers on

mendeley
81 Mendeley
Title
Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome
Published in
JAMA Neurology, March 2021
DOI 10.1001/jamaneurol.2021.0504
Pubmed ID
Authors

Kerri L. LaRovere, Becky J. Riggs, Tina Y. Poussaint, Cameron C. Young, Margaret M. Newhams, Mia Maamari, Tracie C. Walker, Aalok R. Singh, Heda Dapul, Charlotte V. Hobbs, Gwenn E. McLaughlin, Mary Beth F. Son, Aline B. Maddux, Katharine N. Clouser, Courtney M. Rowan, John K. McGuire, Julie C. Fitzgerald, Shira J. Gertz, Steven L. Shein, Alvaro Coronado Munoz, Neal J. Thomas, Katherine Irby, Emily R. Levy, Mary A. Staat, Mark W. Tenforde, Leora R. Feldstein, Natasha B. Halasa, John S. Giuliano, Mark W. Hall, Michele Kong, Christopher L. Carroll, Jennifer E. Schuster, Sule Doymaz, Laura L. Loftis, Keiko M. Tarquinio, Christopher J. Babbitt, Ryan A. Nofziger, Lawrence C. Kleinman, Michael A. Keenaghan, Natalie Z. Cvijanovich, Philip C. Spinella, Janet R. Hume, Kari Wellnitz, Elizabeth H. Mack, Kelly N. Michelson, Heidi R. Flori, Manish M. Patel, Adrienne G. Randolph, First Name and Middle Initial(s)* Last Name*, Mary G Gaspers, Katri V Typpo, Ronald C Sanders, Adam J Schwarz, Helen Harvey, Matt S Zinter, Peter M Mourani, Bria M Coates, Guru Bhoojhawon, Kevin M Havlin, Vicki L Montgomery, Janice E Sullivan, Tamara T Bradford, Melania M Bembea, Susan V Lipton, Ana Lia Graciano, Sabrina R Chen, Suden Kucukak, Jane W Newburger, Ryan W Carroll, Neil D Fernandes, Phoebe H Yager, Kimberly L Marohn, Sabrina M Heidemann, Melissa L Cullimore, Russell J McCulloh, Steven M Horwitz, Simon Li, Rowan F Walsh, Adam J Ratner, Vijaya L Soma, Jennifer K Gillen, Sheemon P Zackai, Kate G Ackerman, Jill M Cholette, Ilana Harwayne-Gidansky, Saul R Hymes, Philip J Overby, Stephanie P Schwartz, Amanda N Lansell, Monica L Koncicki, Joseph Carcillo, Ericka Fink, Dai Kimura, Cindy Bowens, Hillary Crandall, Lincoln S Smith, Pelin Cengiz

Abstract

Coronavirus disease 2019 (COVID-19) affects the nervous system in adult patients. The spectrum of neurologic involvement in children and adolescents is unclear. To understand the range and severity of neurologic involvement among children and adolescents associated with COVID-19. Case series of patients (age <21 years) hospitalized between March 15, 2020, and December 15, 2020, with positive severe acute respiratory syndrome coronavirus 2 test result (reverse transcriptase-polymerase chain reaction and/or antibody) at 61 US hospitals in the Overcoming COVID-19 public health registry, including 616 (36%) meeting criteria for multisystem inflammatory syndrome in children. Patients with neurologic involvement had acute neurologic signs, symptoms, or diseases on presentation or during hospitalization. Life-threatening involvement was adjudicated by experts based on clinical and/or neuroradiologic features. Severe acute respiratory syndrome coronavirus 2. Type and severity of neurologic involvement, laboratory and imaging data, and outcomes (death or survival with new neurologic deficits) at hospital discharge. Of 1695 patients (909 [54%] male; median [interquartile range] age, 9.1 [2.4-15.3] years), 365 (22%) from 52 sites had documented neurologic involvement. Patients with neurologic involvement were more likely to have underlying neurologic disorders (81 of 365 [22%]) compared with those without (113 of 1330 [8%]), but a similar number were previously healthy (195 [53%] vs 723 [54%]) and met criteria for multisystem inflammatory syndrome in children (126 [35%] vs 490 [37%]). Among those with neurologic involvement, 322 (88%) had transient symptoms and survived, and 43 (12%) developed life-threatening conditions clinically adjudicated to be associated with COVID-19, including severe encephalopathy (n = 15; 5 with splenial lesions), stroke (n = 12), central nervous system infection/demyelination (n = 8), Guillain-Barré syndrome/variants (n = 4), and acute fulminant cerebral edema (n = 4). Compared with those without life-threatening conditions (n = 322), those with life-threatening neurologic conditions had higher neutrophil-to-lymphocyte ratios (median, 12.2 vs 4.4) and higher reported frequency of D-dimer greater than 3 μg/mL fibrinogen equivalent units (21 [49%] vs 72 [22%]). Of 43 patients who developed COVID-19-related life-threatening neurologic involvement, 17 survivors (40%) had new neurologic deficits at hospital discharge, and 11 patients (26%) died. In this study, many children and adolescents hospitalized for COVID-19 or multisystem inflammatory syndrome in children had neurologic involvement, mostly transient symptoms. A range of life-threatening and fatal neurologic conditions associated with COVID-19 infrequently occurred. Effects on long-term neurodevelopmental outcomes are unknown.

Twitter Demographics

The data shown below were collected from the profiles of 1,064 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 81 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 15%
Student > Bachelor 10 12%
Unspecified 8 10%
Other 6 7%
Student > Master 6 7%
Other 28 35%
Unknown 11 14%
Readers by discipline Count As %
Medicine and Dentistry 22 27%
Unspecified 9 11%
Neuroscience 8 10%
Nursing and Health Professions 4 5%
Arts and Humanities 3 4%
Other 18 22%
Unknown 17 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 1078. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2021.
All research outputs
#7,057
of 17,702,936 outputs
Outputs from JAMA Neurology
#11
of 2,502 outputs
Outputs of similar age
#445
of 304,708 outputs
Outputs of similar age from JAMA Neurology
#2
of 70 outputs
Altmetric has tracked 17,702,936 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,502 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 57.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 304,708 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.